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Index > Protein center > CXCR1(Gene name) > Human
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  • CXCR1 (Gene name),
  • C-X-C chemokine receptor type 1 (Protein name ),  CXCR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CXCR1(CMKAR1;IL8RA);
    Protein name:
    C-X-C chemokine receptor type 1(CXC-R1;CXCR-1);
    Alternative:
    High affinity interleukin-8 receptor A(IL-8R A);CDw128a;IL-8 receptor type 1;
    CD:
    CD181;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    350
    Sequence:
    50:
    MSNITDPQMW | DFDDLNFTGM | PPADEDYSPC | MLETETLNKY | VVIIAYALVF | 
    100:
    LLSLLGNSLV | MLVILYSRVG | RSVTDVYLLN | LALADLLFAL | TLPIWAASKV | 
    150:
    NGWIFGTFLC | KVVSLLKEVN | FYSGILLLAC | ISVDRYLAIV | HATRTLTQKR | 
    200:
    HLVKFVCLGC | WGLSMNLSLP | FFLFRQAYHP | NNSSPVCYEV | LGNDTAKWRM | 
    250:
    VLRILPHTFG | FIVPLFVMLF | CYGFTLRTLF | KAHMGQKHRA | MRVIFAVVLI | 
    300:
    FLLCWLPYNL | VLLADTLMRT | QVIQESCERR | NNIGRALDAT | EILGFLHSCL | 
    350:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    Pfam:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human CXC-R1
    Cat.:
    E0019h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human CXC-R1
    Cat.:
    E0019r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human CXC-R1
    MSDS:
    Please sign in first.
    ELISA Kit for Human CXC-R1
    Cat.:
    E0019m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CXC-R1
    Cat.:
    U0019r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CXC-R1
    Cat.:
    U0019Rb
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CXC-R1
    Cat.:
    U0019h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human CXC-R1
    Cat.:
    U0019m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human CXC-R1
    Polyclonal Antibody for Human CXC-R1
    Cat.:
    P0019Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CXC-R1
    Cat.:
    P0019Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CXC-R1
    Cat.:
    P0019Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human CXC-R1
    Monoclonal Antibody for Human CXC-R1
    Monoclonal Antibody for Human CXC-R1
    Monoclonal Antibody for Human CXC-R1
    Protein for Human CXC-R1
    Protein for Human CXC-R1
    Protein for Human CXC-R1
    Protein for Human CXC-R1

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    Linearity
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    References
    1. 1.
      "Structure and functional expression of a human interleukin-8 receptor."
      Holmes W.E. , Lee J. , Kuang W.-J. , Rice G.C. , Wood W.I.
      Science253:1278-1280(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];VARIANT THR-276
    2. 2.
      "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2."
      Cerretti D.P. , Kozlosky C.J. , Vanden Bos T. , Nelson N. , Gearing D.P. , Beckmann M.P.
      Mol. Immunol.30:359-367(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION
    3. 3.
      "The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor."
      Mollereau C. , Passage E. , Mattei M.-G. , Vassart G. , Parmentier M.
      Genomics16:248-251(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B."
      Ahuja S.K. , Shetty A. , Tiffany H.L. , Murphy P.M.
      J. Biol. Chem.269:26381-26389(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    5. 5.
      "Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils."
      Liu Y. , Yang S. , Lin A.A. , Cavalli-Sforza L.L. , Su B.
      J. Mol. Evol.61:691-696(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-31; THR-276 AND CYS-335
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      SeattleSNPs variation discovery resource
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-31; THR-276; CYS-335 AND LEU-342
    9. 9.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS ARG-31 AND CYS-335
      tissue: Blood.
    12. 12.
      "Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3."
      Kato H. , Tsuchiya N. , Tokunaga K.
      Genes Immun.1:330-337(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 223-350;VARIANTS THR-276; THR-306 AND CYS-335
    13. 13.
      "Characterization of two high affinity human interleukin-8 receptors."
      Lee J. , Horuk R. , Rice G.C. , Bennett G.L. , Camerato T. , Wood W.I.
      J. Biol. Chem.267:16283-16287(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    14. 14.
      "Structure of a CXC chemokine-receptor fragment in complex with interleukin-8."
      Skelton N.J. , Quan C. , Reilly D. , Lowman H.
      Structure7:157-168(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 9-29 IN COMPLEX WITH IL-8
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