GAD2 ELISA Kit for Human(Homo sapiens) | EIAab.comGAD2 ELISA Kit for Human(Homo sapiens)

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GAD2 (Gene name),

Glutamate decarboxylase 2 (Protein name ), DCE2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GAD2(GAD65);

Protein name:

Glutamate decarboxylase 2;

Alternative:

Glutamate decarboxylase 65 kDa isoform;65 kDa glutamic acid decarboxylase(GAD-65);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Catalyzes the production of GABA.

Subcellular Location:

Cytoplasm cytosol Cytoplasmic vesicle Cell junction synapse presynaptic cell membrane Lipid-anchor Golgi apparatus membrane Peripheral membrane protein Cytoplasmic side Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.

Protein Attributes:

Sequence length:

585

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

585:

GDKVNFFRMV | ISNPAATHQD | IDFLIEEIER | LGQDL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

138275

String:

Q05329

SMR:

Q05329

UniGene:

Hs.231829

KEGG:

hsa:2572

STRING:

9606.ENSP00000259271

Pfam:

PF00282

Uniprot:

Q05329

FOR

ELISA Kit for Human Glutamate decarboxylase 2

Cat.:

E0157m

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96T

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ELISA Kit for Human Glutamate decarboxylase 2

Cat.:

E0157d

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96T

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ELISA Kit for Human Glutamate decarboxylase 2

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E0157h

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ELISA Kit for Human Glutamate decarboxylase 2

Cat.:

E0157p

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96T

ELISA Kit for Human Glutamate decarboxylase 2

Cat.:

E0157r

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96T

CLIA Kit for Human Glutamate decarboxylase 2

Cat.:

U0157d

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96T

CLIA Kit for Human Glutamate decarboxylase 2

Cat.:

U0157h

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human Glutamate decarboxylase 2

Cat.:

U0157m

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Packing:

96T

CLIA Kit for Human Glutamate decarboxylase 2

Cat.:

U0157r

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96T

CLIA Kit for Human Glutamate decarboxylase 2

Cat.:

U0157p

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Polyclonal Antibody for Human Glutamate decarboxylase 2

Cat.:

P0157Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Glutamate decarboxylase 2

Cat.:

P0157Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Glutamate decarboxylase 2

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P0157Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Glutamate decarboxylase 2

Protein for Human Glutamate decarboxylase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10."
Karlsen A.E. , Hagopian W.A. , Grubin C.E. , Dube S. , Disteche C.M. , Adler D.A. , Barmeier H. , Mathewes S. , Grant F.J. , Foster D. , Lernmark A.
Proc. Natl. Acad. Sci. U.S.A.88:8337-8341(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Pancreatic islet.
2.

"Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene."
Bu D.-F. , Erlander M.G. , Hitz B.C. , Tillakaratne N.J. , Kaufman D.L. , Wagner-Mcpherson C.B. , Evans G.A. , Tobin A.J.
Proc. Natl. Acad. Sci. U.S.A.89:2115-2119(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD."
Bu D.-F. , Tobin A.J.
Genomics21:222-228(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

NIEHS SNPs program
Submitted (2003-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-12; ASN-124; ARG-286 AND GLN-375
5.

"Characterization of a linear epitope within the human pancreatic 64-kDa glutamic acid decarboxylase and its autoimmune recognition by sera from insulin-dependent diabetes mellitus patients."
Mauch L. , Abney C.C. , Berg H. , Scherbaum W.A. , Liedvogel B. , Northemann W.
Eur. J. Biochem.212:597-603(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-585
tissue: Pancreas.
6.

"Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets."
Kim J. , Richter W. , Aanstoot H.-J. , Shi Y. , Fu Q. , Rajotte R. , Warnock G. , Baekkeskov S.
Diabetes42:1799-1808(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 245-585
7.

"Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha."
Namchuk M. , Lindsay L. , Turck C.W. , Kanaani J. , Baekkeskov S.
J. Biol. Chem.272:1548-1557(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-3; SER-6; SER-10 AND SER-13;BIOPHYSICOCHEMICAL PROPERTIES
8.

"A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65."
Kanaani J. , El-Din El-Husseini A. , Aguilera-Moreno A. , Diacovo J.M. , Bredt D.S. , Baekkeskov S.
J. Cell Biol.158:1229-1238(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PALMITOYLATION AT CYS-30 AND CYS-45
9.

"A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes."
Corper A.L. , Stratmann T. , Apostolopoulos V. , Scott C.A. , Garcia K.C. , Kang A.S. , Wilson I.A. , Teyton L.
Science288:505-511(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 222-235 IN COMPLEX WITH MHC
10.

"GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop."
Fenalti G. , Law R.H.P. , Buckle A.M. , Langendorf C. , Tuck K. , Rosado C.J. , Faux N.G. , Mahmood K. , Hampe C.S. , Banga J.P. , Wilce M. , Schmidberger J. , Rossjohn J. , El-Kabbani O. , Pike R.N. , Smith A.I. , Mackay I.R. , Rowley M.J. , more...
Nat. Struct. Mol. Biol.14:280-286(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 88-584 IN COMPLEX WITH SUBSTRATE;SUBUNIT;COFACTOR

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