DMP1 ELISA Kit for Human(Homo sapiens) | EIAab.comDMP1 ELISA Kit for Human(Homo sapiens)

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DMP1 (Gene name),

Dentin matrix acidic phosphoprotein 1 (Protein name ), DMP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

DMP1;

Protein name:

Dentin matrix acidic phosphoprotein 1(DMP-1;Dentin matrix protein 1);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with importin alpha.

Function:

May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.

Subcellular Location:

Nucleus Cytoplasm Secreted extracellular space extracellular matrix In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralizated matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.

Protein Attributes:

Sequence length:

513

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

513:

IGDQDDNDCQ | DGY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:1758

String:

Q13316

UniGene:

Hs.652366

MIM:

241520

STRING:

9606.ENSP00000340935

Pfam:

PF07263

Uniprot:

Q13316

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ELISA Kit for Human DMP-1

Cat.:

E2078r

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96T

ELISA Kit for Human DMP-1

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E2078h

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96T

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ELISA Kit for Human DMP-1

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E2078m

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96T

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ELISA Kit for Human DMP-1

Cat.:

E2078b

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96T

CLIA Kit for Human DMP-1

Cat.:

U2078m

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96T

CLIA Kit for Human DMP-1

Cat.:

U2078h

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96T

CLIA Kit for Human DMP-1

Cat.:

U2078r

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96T

CLIA Kit for Human DMP-1

Cat.:

U2078b

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96T

Polyclonal Antibody for Human DMP-1

Cat.:

P2078Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human DMP-1

Cat.:

P2078Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human DMP-1

Cat.:

P2078Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human DMP-1

Protein for Human DMP-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II."
Hirst K.L. , Simmons D. , Feng J. , Aplin H. , Dixon M.J. , McDougall M.
Genomics42:38-45(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Molar.
2.

McDougall M. , Juan X. , Simmons D. , Feng J.
Submitted (1996-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT CYS-69
3.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21."
Aplin H.M. , Hirst K.L. , Crosby A.H. , Dixon M.J.
Genomics30:347-349(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 462-513;GENE MAPPING
6.

"Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store."
Narayanan K. , Ramachandran A. , Hao J. , He G. , Park K.W. , Cho M. , George A.
J. Biol. Chem.278:17500-17508(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION;INTERACTION WITH IMPORTIN ALPHA
7.

"DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis."
Lorenz-Depiereux B. , Bastepe M. , Benet-Pages A. , Amyere M. , Wagenstaller J. , Mueller-Barth U. , Badenhoop K. , Kaiser S.M. , Rittmaster R.S. , Shlossberg A.H. , Olivares J.L. , Loris C. , Ramos F.J. , Glorieux F. , Vikkula M. , Jueppner H. , Strom T.M.
Nat. Genet.38:1248-1250(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ARHR1;VARIANTS CYS-69; ASN-117 AND HIS-272
8.

"Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism."
Feng J.Q. , Ward L.M. , Liu S. , Lu Y. , Xie Y. , Yuan B. , Yu X. , Rauch F. , Davis S.I. , Zhang S. , Rios H. , Drezner M.K. , Quarles L.D. , Bonewald L.F. , White K.E.
Nat. Genet.38:1310-1315(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ARHR1
9.

"Secreted kinase phosphorylates extracellular proteins that regulate biomineralization."
Tagliabracci V.S. , Engel J.L. , Wen J. , Wiley S.E. , Worby C.A. , Kinch L.N. , Xiao J. , Grishin N.V. , Dixon J.E.
Science336:1150-1153(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY FAM20C

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