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Index > Protein center > DNMT1(Gene name) > Human
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  • DNMT1 (Gene name),
  • DNA (cytosine-5)-methyltransferase 1 (Protein name ),  DNMT1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    DNMT1(AIM;CXXC9;DNMT);
    Protein name:
    DNA (cytosine-5)-methyltransferase 1(Dnmt1);
    Alternative:
    DNA methyltransferase HsaI(DNA MTase HsaI;M.HsaI);CXXC-type zinc finger protein 9;MCMT;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1. Interacts with DNMT3A and DNMT3B. Interacts with the PRC2/EED-EZH2 complex. Interacts with UBC9 and BAZ2A/TIP5.
    Function:
    Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    1616
    Sequence:
    50:
    MPARTAPARV | PTLAVPAISL | PDDVRRRLKD | LERDSLTEKE | CVKEKLNLLH | 
    100:
    EFLQTEIKNQ | LCDLETKLRK | EELSEEGYLA | KVKSLLNKDL | SLENGAHAYN | 
    150:
    REVNGRLENG | NQARSEARRV | GMADANSPPK | PLSKPRTPRR | SKSDGEAKPE | 
    200:
    PSPSPRITRK | STRQTTITSH | FAKGPAKRKP | QEESERAKSD | ESIKEEDKDQ | 
    250:
    DEKRRRVTSR | ERVARPLPAE | EPERAKSGTR | TEKEEERDEK | EEKRLRSQTK | 
    300:
    EPTPKQKLKE | EPDREARAGV | QADEDEDGDE | KDEKKHRSQP | KDLAAKRRPE | 
    350:
    EKEPEKVNPQ | ISDEKDEDEK | EEKRRKTTPK | EPTEKKMARA | KTVMNSKTHP | 
    400:
    PKCIQCGQYL | DDPDLKYGQH | PPDAVDEPQM | LTNEKLSIFD | ANESGFESYE | 
    450:
    ALPQHKLTCF | SVYCKHGHLC | PIDTGLIEKN | IELFFSGSAK | PIYDDDPSLE | 
    500:
    GGVNGKNLGP | INEWWITGFD | GGEKALIGFS | TSFAEYILMD | PSPEYAPIFG | 
    550:
    LMQEKIYISK | IVVEFLQSNS | DSTYEDLINK | IETTVPPSGL | NLNRFTEDSL | 
    600:
    LRHAQFVVEQ | VESYDEAGDS | DEQPIFLTPC | MRDLIKLAGV | TLGQRRAQAR | 
    650:
    RQTIRHSTRE | KDRGPTKATT | TKLVYQIFDT | FFAEQIEKDD | REDKENAFKR | 
    700:
    RRCGVCEVCQ | QPECGKCKAC | KDMVKFGGSG | RSKQACQERR | CPNMAMKEAD | 
    750:
    DDEEVDDNIP | EMPSPKKMHQ | GKKKKQNKNR | ISWVGEAVKT | DGKKSYYKKV | 
    800:
    CIDAETLEVG | DCVSVIPDDS | SKPLYLARVT | ALWEDSSNGQ | MFHAHWFCAG | 
    850:
    TDTVLGATSD | PLELFLVDEC | EDMQLSYIHS | KVKVIYKAPS | ENWAMEGGMD | 
    900:
    PESLLEGDDG | KTYFYQLWYD | QDYARFESPP | KTQPTEDNKF | KFCVSCARLA | 
    950:
    EMRQKEIPRV | LEQLEDLDSR | VLYYSATKNG | ILYRVGDGVY | LPPEAFTFNI | 
    1000:
    KLSSPVKRPR | KEPVDEDLYP | EHYRKYSDYI | KGSNLDAPEP | YRIGRIKEIF | 
    1050:
    CPKKSNGRPN | ETDIKIRVNK | FYRPENTHKS | TPASYHADIN | LLYWSDEEAV | 
    1100:
    VDFKAVQGRC | TVEYGEDLPE | CVQVYSMGGP | NRFYFLEAYN | AKSKSFEDPP | 
    1150:
    NHARSPGNKG | KGKGKGKGKP | KSQACEPSEP | EIEIKLPKLR | TLDVFSGCGG | 
    1200:
    LSEGFHQAGI | SDTLWAIEMW | DPAAQAFRLN | NPGSTVFTED | CNILLKLVMA | 
    1250:
    GETTNSRGQR | LPQKGDVEML | CGGPPCQGFS | GMNRFNSRTY | SKFKNSLVVS | 
    1300:
    FLSYCDYYRP | RFFLLENVRN | FVSFKRSMVL | KLTLRCLVRM | GYQCTFGVLQ | 
    1350:
    AGQYGVAQTR | RRAIILAAAP | GEKLPLFPEP | LHVFAPRACQ | LSVVVDDKKF | 
    1400:
    VSNITRLSSG | PFRTITVRDT | MSDLPEVRNG | ASALEISYNG | EPQSWFQRQL | 
    1450:
    RGAQYQPILR | DHICKDMSAL | VAARMRHIPL | APGSDWRDLP | NIEVRLSDGT | 
    1500:
    MARKLRYTHH | DRKNGRSSSG | ALRGVCSCVE | AGKACDPAAR | QFNTLIPWCL | 
    1550:
    PHTGNRHNHW | AGLYGRLEWD | GFFSTTVTNP | EPMGKQGRVL | HPEQHRVVSV | 
    1600:
    RECARSQGFP | DTYRLFGNIL | DKHRQVGNAV | PPPLAKAIGL | EIKLCMLAKA | 
    1616:
    RESASAKIKE | EEAAKD
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    UniGene:
    Pfam:
    SMR:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Dnmt1
    Cat.:
    E2102h
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    ELISA Kit for Human Dnmt1
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    E2102c
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    Packing:
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    ELISA Kit for Human Dnmt1
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    E2102m
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    ELISA Kit for Human Dnmt1
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    E2102b
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    ELISA Kit for Human Dnmt1
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    E2102r
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    Packing:
    96T
    CLIA Kit for Human Dnmt1
    Cat.:
    U2102m
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    CLIA Kit for Human Dnmt1
    Cat.:
    U2102h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Dnmt1
    Cat.:
    U2102c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Dnmt1
    Cat.:
    U2102r
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    CLIA Kit for Human Dnmt1
    Cat.:
    U2102b
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    MSDS:
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    Packing:
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    Polyclonal Antibody for Human Dnmt1
    Polyclonal Antibody for Human Dnmt1
    Cat.:
    P2102Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Dnmt1
    Cat.:
    P2102Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Dnmt1
    Cat.:
    P2102Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Dnmt1
    Monoclonal Antibody for Human Dnmt1
    Monoclonal Antibody for Human Dnmt1
    Monoclonal Antibody for Human Dnmt1
    Monoclonal Antibody for Human Dnmt1
    Monoclonal Antibody for Human Dnmt1
    Protein for Human Dnmt1
    Protein for Human Dnmt1
    Protein for Human Dnmt1
    Protein for Human Dnmt1
    Protein for Human Dnmt1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and characterization of the cDNA encoding human DNA methyltransferase."
      Yen R.-W.C. , Vertino P.M. , Nelkin B.D. , Yu J.J. , Deiry W.E. , Cumaraswamy A. , Lennon G.G. , Trask B.J. , Celano P. , Baylin S.B.
      Nucleic Acids Res.20:2287-2291(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase."
      Yoder J.A. , Yen R.-W.C. , Vertino P.M. , Bestor T.H. , Baylin S.B.
      J. Biol. Chem.271:31092-31097(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO N-TERMINUS
    3. 3.
      "Human DNA methyltransferase (DNMT1) is alternatively spliced."
      Li L.C. , Au H. , Chui R. , Dahiya R.
      Submitted (1999-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
      tissue: Prostatic carcinoma.
    4. 4.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    6. 6.
      "Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues."
      Hsu D.-W. , Lin M.-J. , Lee T.-L. , Wen S.-C. , Chen X. , Shen C.-K.J.
      Proc. Natl. Acad. Sci. U.S.A.96:9751-9756(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2)
    7. 7.
      "Characterization of the human DNA methyltransferase splice variant Dnmt1b."
      Bonfils C. , Beaulieu N. , Chan E. , Cotton-Montpetit J. , MacLeod A.R.
      J. Biol. Chem.275:10754-10760(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2)
    8. 8.
      "Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1."
      Chuang L.S.-H. , Ian H.-I. , Koh T.-W. , Ng H.-H. , Xu G. , Li B.F.L.
      Science277:1996-2000(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PCNA;MUTAGENESIS
    9. 9.
      "MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase."
      Tatematsu K. , Yamazaki T. , Ishikawa F.
      Genes Cells5:677-688(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MBD2 AND MBD3
    10. 10.
      "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci."
      Rountree M.R. , Bachman K.E. , Baylin S.B.
      Nat. Genet.25:269-277(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC2 AND DMAP1
    11. 11.
      "DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters."
      Robertson K.D. , Ait-Si-Ali S. , Yokochi T. , Wade P.A. , Jones P.L. , Wolffe A.P.
      Nat. Genet.25:338-342(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RB1; E2F1 AND HDAC1
    12. 12.
      "The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors."
      Robertson K.D. , Uzvolgyi E. , Liang G. , Talmadge C. , Sumegi J. , Gonzales F.A. , Jones P.A.
      Nucleic Acids Res.27:2291-2298(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    13. 13.
      "Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases."
      Kim G.-D. , Ni J. , Kelesoglu N. , Roberts R.J. , Pradhan S.
      EMBO J.21:4183-4195(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNMT3A AND DNMT3B;SUBCELLULAR LOCATION
    14. 14.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127 AND SER-714;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EED AND EZH2
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    17. 17.
      "Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer."
      Schlesinger Y. , Straussman R. , Keshet I. , Farkash S. , Hecht M. , Zimmerman J. , Eden E. , Yakhini Z. , Ben-Shushan E. , Reubinoff B.E. , Bergman Y. , Simon I. , Cedar H.
      Nat. Genet.39:232-236(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DE NOVO DNA METHYLATION OF TARGET GENES
    18. 18.
      "CXXC domain of human DNMT1 is essential for enzymatic activity."
      Pradhan M. , Esteve P.-O. , Chin H.G. , Samaranayke M. , Kim G.-D. , Pradhan S.
      Biochemistry47:10000-10009(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-653; CYS-656; CYS-659; CYS-664; CYS-667 AND CYS-670
    19. 19.
      "DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation."
      Sun L. , Huang L. , Nguyen P. , Bisht K.S. , Bar-Sela G. , Ho A.S. , Bradbury C.M. , Yu W. , Cui H. , Lee S. , Trepel J.B. , Feinberg A.P. , Gius D.
      Cancer Res.68:2726-2735(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    20. 20.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-732;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    21. 21.
      "Protein lysine methyltransferase G9a acts on non-histone targets."
      Rathert P. , Dhayalan A. , Murakami M. , Zhang X. , Tamas R. , Jurkowska R. , Komatsu Y. , Shinkai Y. , Cheng X. , Jeltsch A.
      Nat. Chem. Biol.4:344-346(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT LYS-70;IDENTIFICATION BY MASS SPECTROMETRY
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127; SER-143; SER-152; SER-154 AND SER-394;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    23. 23.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    24. 24.
      "SUMOylation enhances DNA methyltransferase 1 activity."
      Lee B. , Muller M.T.
      Biochem. J.421:449-461(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION;INTERACTION WITH UBC9;MUTAGENESIS OF CYS-1226
    25. 25.
      "Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain."
      Fellinger K. , Rothbauer U. , Felle M. , Laengst G. , Leonhardt H.
      J. Cell. Biochem.106:521-528(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HOMODIMERIZATION
    26. 26.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    27. 27.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-173; LYS-1111; LYS-1113 AND LYS-1115;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    28. 28.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394 AND SER-714;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    29. 29.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    30. 30.
      "Phosphorylation of human DNMT1: implication of cyclin-dependent kinases."
      Lavoie G. , St-Pierre Y.
      Biochem. Biophys. Res. Commun.409:187-192(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-154
    31. 31.
      "SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities."
      Peng L. , Yuan Z. , Ling H. , Fukasawa K. , Robertson K. , Olashaw N. , Koomen J. , Chen J. , Lane W.S. , Seto E.
      Mol. Cell. Biol.31:4720-4734(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-160; LYS-188; LYS-259; LYS-366; LYS-749; LYS-891; LYS-957; LYS-961; LYS-975; LYS-1054; LYS-1111; LYS-1113; LYS-1115; LYS-1117; LYS-1349 AND LYS-1415;DEACETYLATION BY SIRT1
    32. 32.
      "A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability."
      Esteve P.O. , Chang Y. , Samaranayake M. , Upadhyay A.K. , Horton J.R. , Feehery G.R. , Cheng X. , Pradhan S.
      Nat. Struct. Mol. Biol.18:42-48(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT LYS-142;PHOSPHORYLATION AT SER-143
    33. 33.
      "The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1."
      Felle M. , Joppien S. , Nemeth A. , Diermeier S. , Thalhammer V. , Dobner T. , Kremmer E. , Kappler R. , Langst G.
      Nucleic Acids Res.39:8355-8365(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP7 AND UHRF1
    34. 34.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127; SER-133 AND SER-714;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    35. 35.
      "The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1."
      Syeda F. , Fagan R.L. , Wean M. , Avvakumov G.V. , Walker J.R. , Xue S. , Dhe-Paganon S. , Brenner C.
      J. Biol. Chem.286:15344-15351(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.31 ANGSTROMS) OF 351-600 IN COMPLEX WITH ZINC IONS
    36. 36.
      "Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation."
      Song J. , Rechkoblit O. , Bestor T.H. , Patel D.J.
      Science331:1036-1040(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS) OF 646-1600 IN COMPLEX WITH SAH AND DNA;AUTOINHIBITORY LINKER
    37. 37.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HSN1E 490-GLU-TYR-491 AND CYS-495;CHARACTERIZATION OF VARIANTS HSN1E 490-GLU-TYR-491 AND CYS-495
    38. 38.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ADCADN VAL-554; ALA-589 AND PHE-590
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