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Index > Protein center > DHFR(Gene name) > Human
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  • DHFR (Gene name),
  • Dihydrofolate reductase (Protein name ),  DYR_HUMAN from NCBI database.
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  • General Annotation
  • |
  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    DHFR;
    Protein name:
    Dihydrofolate reductase;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    187
    Sequence:
    50:
    MVGSLNCIVA | VSQNMGIGKN | GDLPWPPLRN | EFRYFQRMTT | TSSVEGKQNL | 
    100:
    VIMGKKTWFS | IPEKNRPLKG | RINLVLSREL | KEPPQGAHFL | SRSLDDALKL | 
    150:
    TEQPELANKV | DMVWIVGGSS | VYKEAMNHPG | HLKLFVTRIM | QDFESDTFFP | 
    187:
    EIDLEKYKLL | PEYPGVLSDV | QEEKGIKYKF | EVYEKND
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    KEGG:
    SMR:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Dihydrofolate reductase
    Cat.:
    E9276h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Dihydrofolate reductase
    MSDS:
    Please sign in first.
    ELISA Kit for Human Dihydrofolate reductase
    Cat.:
    E9276m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Dihydrofolate reductase
    Cat.:
    E9276r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Dihydrofolate reductase
    Cat.:
    E9276p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Dihydrofolate reductase
    Cat.:
    E9276b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dihydrofolate reductase
    Cat.:
    U9276b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dihydrofolate reductase
    Cat.:
    U9276r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dihydrofolate reductase
    Cat.:
    U9276p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dihydrofolate reductase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Dihydrofolate reductase
    Cat.:
    U9276h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Dihydrofolate reductase
    Cat.:
    U9276m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Dihydrofolate reductase
    Polyclonal Antibody for Human Dihydrofolate reductase
    Polyclonal Antibody for Human Dihydrofolate reductase
    Polyclonal Antibody for Human Dihydrofolate reductase
    Polyclonal Antibody for Human Dihydrofolate reductase
    Cat.:
    P9276Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Dihydrofolate reductase
    Cat.:
    P9276Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Dihydrofolate reductase
    Monoclonal Antibody for Human Dihydrofolate reductase
    Monoclonal Antibody for Human Dihydrofolate reductase
    Monoclonal Antibody for Human Dihydrofolate reductase
    Monoclonal Antibody for Human Dihydrofolate reductase
    Monoclonal Antibody for Human Dihydrofolate reductase
    Protein for Human Dihydrofolate reductase
    Protein for Human Dihydrofolate reductase
    Protein for Human Dihydrofolate reductase
    Protein for Human Dihydrofolate reductase
    Protein for Human Dihydrofolate reductase
    Protein for Human Dihydrofolate reductase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase."
      Masters J.N. , Attardi G.
      Gene21:59-63(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Human dihydrofolate reductase gene organization. Extensive conservation of the G + C-rich 5' non-coding sequence and strong intron size divergence from homologous mammalian genes."
      Yang J.K. , Masters J.N. , Attardi G.
      J. Mol. Biol.176:169-187(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Eye.
    6. 7.
      "Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency."
      Banka S. , Blom H.J. , Walter J. , Aziz M. , Urquhart J. , Clouthier C.M. , Rice G.I. , de Brouwer A.P. , Hilton E. , Vassallo G. , Will A. , Smith D.E. , Smulders Y.M. , Wevers R.A. , Steinfeld R. , Heales S. , Crow Y.J. , Pelletier J.N. , more...
      Am. J. Hum. Genet.88:216-225(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;VARIANT DHFRD PHE-80
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 9.
      "The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional."
      McEntee G. , Minguzzi S. , O'Brien K. , Ben Larbi N. , Loscher C. , O'Fagain C. , Parle-McDermott A.
      Proc. Natl. Acad. Sci. U.S.A.108:15157-15162(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;RNA-BINDING;BIOPHYSICOCHEMICAL PROPERTIES
    9. 10.
      "Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria."
      Anderson D.D. , Quintero C.M. , Stover P.J.
      Proc. Natl. Acad. Sci. U.S.A.108:15163-15168(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 11.
      "Crystal structure of human dihydrofolate reductase complexed with folate."
      Oefner C. , D'Arcy A. , Winkler F.K.
      Eur. J. Biochem.174:377-385(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH FOLATE
    11. 12.
      "Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate."
      Davies J.F. , Delcamp T.J. , Prendergast N.J. , Ashford V.A. , Freisheim J.H. , Kraut J.
      Biochemistry29:9467-9479(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEXES WITH FOLATE AND 5-DEAZAFOLATE;SUBUNIT
    12. 13.
      "Sequence-specific 1H and 15N resonance assignments for human dihydrofolate reductase in solution."
      Stockman B.J. , Nirmala N.R. , Wagner G. , Delcamp T.J. , Deyarman M.T. , Freisheim J.H.
      Biochemistry31:218-229(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    13. 14.
      "Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers."
      Lewis W.S. , Cody V. , Galitsky N. , Luft J.R. , Pangborn W. , Chunduru S.K. , Spencer H.T. , Appleman J.R. , Blakley R.L.
      J. Biol. Chem.270:5057-5064(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEXES WITH NADPH; PIRITREXIM AND METOTHREXATE;MUTAGENESIS OF LEU-23
    14. 15.
      "Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523."
      Cody V. , Galitsky N. , Luft J.R. , Pangborn W. , Blakley R.L. , Gangjee A.
      Biochemistry36:13897-13903(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS)
    15. 16.
      "Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents."
      Gangjee A. , Vidwans A.P. , Vasudevan A. , Queener S.F. , Kisliuk R.L. , Cody V. , Li R. , Galitsky N. , Luft J.R. , Pangborn W.
      J. Med. Chem.41:3426-3434(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEXES WITH NADPH AND QUINAZOLINE INHIBITORS;CATALYTIC ACTIVITY
    16. 17.
      "Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 A and 1.05 A resolution."
      Klon A.E. , Heroux A. , Ross L.J. , Pathak V. , Johnson C.A. , Piper J.R. , Borhani D.W.
      J. Mol. Biol.320:677-693(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS) IN COMPLEXES WITH NADP AND THE SYNTHETIC INHIBITORS SRI-9439 AND SRI-9662;FUNCTION;CATALYTIC ACTIVITY
    17. 18.
      "Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase."
      Cody V. , Galitsky N. , Luft J.R. , Pangborn W. , Gangjee A.
      Acta Crystallogr. D59:654-661(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH INHIBITOR
    18. 19.
      "Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase."
      Cody V. , Luft J.R. , Pangborn W. , Gangjee A.
      Acta Crystallogr. D59:1603-1609(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH INHIBITOR
    19. 20.
      "Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry."
      Cody V. , Luft J.R. , Pangborn W. , Gangjee A. , Queener S.F.
      Acta Crystallogr. D60:646-655(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH NADPH AND INHIBITOR;MUTAGENESIS OF GLN-36 AND ASN-65;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES
    20. 21.
      "Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH."
      Cody V. , Luft J.R. , Pangborn W.
      Acta Crystallogr. D61:147-155(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEXES WITH NADP AND METHOTREXATE;MUTAGENESIS OF LEU-23
    21. 22.
      "Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH."
      Kovalevskaya N.V. , Smurnyy Y.D. , Polshakov V.I. , Birdsall B. , Bradbury A.F. , Frenkiel T. , Feeney J.
      J. Biomol. NMR33:69-72(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR IN COMPLEX WITH TRIMETHOPRIM AND NADPH
    22. 23.
      "Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation."
      Reynolds R.C. , Campbell S.R. , Fairchild R.G. , Kisliuk R.L. , Micca P.L. , Queener S.F. , Riordan J.M. , Sedwick W.D. , Waud W.R. , Leung A.K. , Dixon R.W. , Suling W.J. , Borhani D.W.
      J. Med. Chem.50:3283-3289(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEXES WITH NADP AND BORON-CONTAINING INHIBITORS;CATALYTIC ACTIVITY
    23. 24.
      "Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes."
      Cody V. , Pace J. , Makin J. , Piraino J. , Queener S.F. , Rosowsky A.
      Biochemistry48:1702-1711(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.23 ANGSTROMS) IN COMPLEXES WITH NADP AND THE SYNTHETIC INHIBITOR PY957;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF GLN-36 AND ASN-65
    24. 25.
      "Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance."
      Volpato J.P. , Yachnin B.J. , Blanchet J. , Guerrero V. , Poulin L. , Fossati E. , Berghuis A.M. , Pelletier J.N.
      J. Biol. Chem.284:20079-20089(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF MUTANT ARG-32/GLU-36 IN COMPLEX WITH METHOTREXATE AND NADP;MUTAGENESIS OF PHE-32 AND GLN-36;CATALYTIC ACTIVITY
    25. 26.
      "Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents."
      Gangjee A. , Li W. , Kisliuk R.L. , Cody V. , Pace J. , Piraino J. , Makin J.
      J. Med. Chem.52:4892-4902(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.24 ANGSTROMS) OF 1-187
    26. 27.
      "Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease."
      Cario H. , Smith D.E. , Blom H. , Blau N. , Bode H. , Holzmann K. , Pannicke U. , Hopfner K.P. , Rump E.M. , Ayric Z. , Kohne E. , Debatin K.M. , Smulders Y. , Schwarz K.
      Am. J. Hum. Genet.88:226-231(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DHFRD VAL-153
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