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Index > Protein center > ENG(Gene name) > Human
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  • ENG (Gene name),
  • Endoglin (Protein name ),  EGLN_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ENG(END);
    Protein name:
    Endoglin;
    Alternative:

    CD:
    CD105;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2.
    Function:
    Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    658
    Sequence:
    50:
    MDRGTLPLAV | ALLLASCSLS | PTSLAETVHC | DLQPVGPERG | EVTYTTSQVS | 
    100:
    KGCVAQAPNA | ILEVHVLFLE | FPTGPSQLEL | TLQASKQNGT | WPREVLLVLS | 
    150:
    VNSSVFLHLQ | ALGIPLHLAY | NSSLVTFQEP | PGVNTTELPS | FPKTQILEWA | 
    200:
    AERGPITSAA | ELNDPQSILL | RLGQAQGSLS | FCMLEASQDM | GRTLEWRPRT | 
    250:
    PALVRGCHLE | GVAGHKEAHI | LRVLPGHSAG | PRTVTVKVEL | SCAPGDLDAV | 
    300:
    LILQGPPYVS | WLIDANHNMQ | IWTTGEYSFK | IFPEKNIRGF | KLPDTPQGLL | 
    350:
    GEARMLNASI | VASFVELPLA | SIVSLHASSC | GGRLQTSPAP | IQTTPPKDTC | 
    400:
    SPELLMSLIQ | TKCADDAMTL | VLKKELVAHL | KCTITGLTFW | DPSCEAEDRG | 
    450:
    DKFVLRSAYS | SCGMQVSASM | ISNEAVVNIL | SSSSPQRKKV | HCLNMDSLSF | 
    500:
    QLGLYLSPHF | LQASNTIEPG | QQSFVQVRVS | PSVSEFLLQL | DSCHLDLGPE | 
    550:
    GGTVELIQGR | AAKGNCVSLL | SPSPEGDPRF | SFLLHFYTVP | IPKTGTLSCT | 
    600:
    VALRPKTGSQ | DQEVHRTVFM | RLNIISPDLS | GCTSKGLVLP | AVLGITFGAF | 
    650:
    LIGALLTAAL | WYIYSHTRSP | SKREPVVAVA | APASSESSST | NHSIGSTQST | 
    658:
    PCSTSSMA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    KEGG:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Endoglin
    Cat.:
    E0980m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Endoglin
    Cat.:
    E0980h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Endoglin
    Cat.:
    E0980p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Endoglin
    Cat.:
    U0980h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Endoglin
    Cat.:
    U0980p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Endoglin
    Cat.:
    U0980m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Endoglin
    Polyclonal Antibody for Human Endoglin
    Cat.:
    P0980Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Endoglin
    Cat.:
    P0980Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Endoglin
    Monoclonal Antibody for Human Endoglin
    Monoclonal Antibody for Human Endoglin
    Protein for Human Endoglin
    Protein for Human Endoglin
    Protein for Human Endoglin

    R&D Technical Data
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    Western blot - Anti-NAMPT antibody

                 12% SDS-PAGE analysis

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions."
      Bellon T. , Corbi A. , Lastres P. , Cales C. , Cebrian M. , Vera S. , Cheifetz S. , Massague J. , Letarte M. , Bernabeu C.
      Eur. J. Immunol.23:2340-2345(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
    2. 2.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells."
      Gougos A. , Letarte M.
      J. Biol. Chem.265:8361-8364(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 14-658;PROTEIN SEQUENCE OF 26-36 (ISOFORM LONG)
      tissue: Umbilical vein.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 122-378
    6. 6.
      "Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors."
      Meng Q.-J. , Lux A. , Holloschi A. , Li J. , Hughes J.M.X. , Foerg T. , McCarthy J.E.G. , Heagerty A.M. , Kioschis P. , Hafner M. , Garland J.M.
      J. Biol. Chem.281:37069-37080(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TCTEX1D4
    7. 7.
      "The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells."
      Lee N.Y. , Blobe G.C.
      J. Biol. Chem.282:21507-21517(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2
    8. 8.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-134
      tissue: Liver.
    9. 9.
      "Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth."
      Castonguay R. , Werner E.D. , Matthews R.G. , Presman E. , Mulivor A.W. , Solban N. , Sako D. , Pearsall R.S. , Underwood K.W. , Seehra J. , Kumar R. , Grinberg A.V.
      J. Biol. Chem.286:30034-30046(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GDF2
    10. 10.
      "Structural and functional insights into endoglin ligand recognition and binding."
      Alt A. , Miguel-Romero L. , Donderis J. , Aristorena M. , Blanco F.J. , Round A. , Rubio V. , Bernabeu C. , Marina A.
      PLoS ONE7:E29948-E29948(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GDF2
    11. 11.
      "Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies."
      Nolan-Stevaux O. , Zhong W. , Culp S. , Shaffer K. , Hoover J. , Wickramasinghe D. , Ruefli-Brasse A.
      PLoS ONE7:E50920-E50920(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia."
      Shovlin C.L. , Hughes J.M.B. , Scott J. , Seidman C.E. , Seidman J.G.
      Am. J. Hum. Genet.61:68-79(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HHT1 192-ARG--PRO-198 DEL;VARIANT MET-5
    13. 13.
      "A novel missense mutation in the endoglin gene in hereditary hemorrhagic telangiectasia."
      Yamaguchi H. , Azuma H. , Shigekiyo T. , Inoue H. , Saito S.
      Thromb. Haemost.77:243-247(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HHT1 ASP-160
    14. 14.
      "Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles."
      Gallione C.J. , Klaus D.J. , Yeh E.Y. , Stenzel T.T. , Xue Y. , Anthony K.B. , McAllister K.A. , Baldwin M.A. , Berg J.N. , Lux A. , Smith J.D. , Vary C.P.H. , Craigen W.J. , Westermann C.J.J. , Warner M.L. , Miller Y.E. , Jackson C.E. , Guttmacher A.E. , more...
      Hum. Mutat.11:286-294(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HHT1 VAL-52; ARG-53; CYS-149 AND PRO-306
    15. 15.
      "Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1."
      Pece-Barbara N. , Cymerman U. , Vera S. , Marchuk D.A. , Letarte M.
      Hum. Mol. Genet.8:2171-2181(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HHT1 VAL-52; ARG-53; CYS-149 AND PRO-221
    16. 16.
      "Two common endoglin mutations in families with hereditary hemorrhagic telangiectasia in the Netherlands Antilles: evidence for a founder effect."
      Gallione C.J. , Scheessele E.A. , Reinhardt D. , Duits A.J. , Berg J.N. , Westermann C.J.J. , Marchuk D.A.
      Hum. Genet.107:40-44(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HHT1 VAL-413
    17. 17.
      "Identification of hereditary hemorrhagic telangiectasia type 1 in newborns by protein expression and mutation analysis of endoglin."
      Cymerman U. , Vera S. , Pece-Barbara N. , Bourdeau A. , White R.I. Jr. , Dunn J. , Letarte M.
      Pediatr. Res.47:24-35(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HHT1 ARG-53
    18. 18.
      "Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France."
      French Rendu-Osler network , Lesca G. , Plauchu H. , Coulet F. , Lefebvre S. , Plessis G. , Odent S. , Riviere S. , Leheup B. , Goizet C. , Carette M.-F. , Cordier J.-F. , Pinson S. , Soubrier F. , Calender A. , Giraud S.
      Hum. Mutat.23:289-299(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HHT1 PRO-8; PHE-49; ARG-107; CYS-207 DEL; THR-263; ARG-232-233-THR DEL; ILE-263 DEL; SER-412 AND MET-504
    19. 19.
      "Hepatic manifestation is associated with ALK1 in hereditary hemorrhagic telangiectasia: identification of five novel ALK1 and one novel ENG mutations."
      Kuehl H.K.A. , Caselitz M. , Hasenkamp S. , Wagner S. , El-Harith E.-H.A. , Manns M.P. , Stuhrmann M.
      Hum. Mutat.25:320-320(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HHT1 PRO-221; ILE-263 DEL AND LEU-615
    20. 20.
      "Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype."
      Bossler A.D. , Richards J. , George C. , Godmilow L. , Ganguly A.
      Hum. Mutat.27:667-675(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HHT1 ASP-11; ASP-105; GLU-175; THR-220; ASP-308; SER-363; TRP-437; SER-490; HIS-529; PRO-547 AND ASP-604
    21. 21.
      "Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia."
      Argyriou L. , Twelkemeyer S. , Panchulidze I. , Wehner L.E. , Teske U. , Engel W. , Nayernia K.
      Int. J. Mol. Med.17:655-659(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HHT1 193-THR-LEU-194 DELINS VAL-LEU-GLN AND ASP-545
    22. 22.
      "Update on molecular diagnosis of hereditary hemorrhagic telangiectasia."
      Richards-Yutz J. , Grant K. , Chao E.C. , Walther S.E. , Ganguly A.
      Hum. Genet.128:61-77(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-150; PRO-205; MET-236; MET-315; GLU-374; ARG-414; SER-545; TYR-549 AND ALA-561;VARIANTS HHT1 GLN-221; GLU-238; SER-263; ARG-269; TYR-394; PRO-529 AND ARG-603
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