Protein name:
Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) ;
Alternative:
Ecto-apyrase ;Ecto-ATP diphosphohydrolase 1 (Ecto-ATPDase 1;Ecto-ATPase 1) ;Lymphoid cell activation antigen ;
CD:
CD39 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; disulfide-linked.
Function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MEDTKESNVK | TFCSKNILAI | LGFSSIIAVI | ALLAVGLTQN | KALPENVKYG |
100:
IVLDAGSSHT | SLYIYKWPAE | KENDTGVVHQ | VEECRVKGPG | ISKFVQKVNE |
150:
IGIYLTDCME | RAREVIPRSQ | HQETPVYLGA | TAGMRLLRME | SEELADRVLD |
200:
VVERSLSNYP | FDFQGARIIT | GQEEGAYGWI | TINYLLGKFS | QKTRWFSIVP |
250:
YETNNQETFG | ALDLGGASTQ | VTFVPQNQTI | ESPDNALQFR | LYGKDYNVYT |
300:
HSFLCYGKDQ | ALWQKLAKDI | QVASNEILRD | PCFHPGYKKV | VNVSDLYKTP |
350:
CTKRFEMTLP | FQQFEIQGIG | NYQQCHQSIL | ELFNTSYCPY | SQCAFNGIFL |
400:
PPLQGDFGAF | SAFYFVMKFL | NLTSEKVSQE | KVTEMMKKFC | AQPWEEIKTS |
450:
YAGVKEKYLS | EYCFSGTYIL | SLLLQGYHFT | ADSWEHIHFI | GKIQGSDAGW |
500:
TLGYMLNLTN | MIPAEQPLST | PLSHSTYVFL | MVLFSLVLFT | VAIIGLLIFH |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Pig
Human
Bovine
ELISA Kit for Human NTPDase 1
ELISA Kit for Human NTPDase 1
ELISA Kit for Human NTPDase 1
ELISA Kit for Human NTPDase 1
ELISA Kit for Human NTPDase 1
CLIA Kit for Human NTPDase 1
CLIA Kit for Human NTPDase 1
CLIA Kit for Human NTPDase 1
CLIA Kit for Human NTPDase 1
CLIA Kit for Human NTPDase 1
Polyclonal Antibody for Human NTPDase 1
Polyclonal Antibody for Human NTPDase 1
Polyclonal Antibody for Human NTPDase 1
Polyclonal Antibody for Human NTPDase 1
Polyclonal Antibody for Human NTPDase 1
Monoclonal Antibody for Human NTPDase 1
Monoclonal Antibody for Human NTPDase 1
Monoclonal Antibody for Human NTPDase 1
Monoclonal Antibody for Human NTPDase 1
Monoclonal Antibody for Human NTPDase 1
Protein for Human NTPDase 1
Protein for Human NTPDase 1
Protein for Human NTPDase 1
Protein for Human NTPDase 1
Protein for Human NTPDase 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization."
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J. Immunol.153:3574-3583(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Umbilical vein .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3)
tissue :
Placenta .
4.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4; 5 AND 6)
tissue :
Brain .
tissue :
Synovium .
tissue :
Trachea .
tissue :
Uterus .
5.
"The DNA sequence and comparative analysis of human chromosome 10."
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Nature429:375-381(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
Mural R.J.
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Istrail S.
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue :
Lung .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 240-242; 162-166; 185-189; 210-223; 243-249 AND 288-297
tissue :
Placenta .
9.
"Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation."
Makita K.
,
Shimoyama T.
,
Sakurai Y.
,
Yagi H.
,
Matsumoto M.
,
Narita N.
,
Sakamoto Y.
,
Saito S.
,
Ikeda Y.
,
Suzuki M.
,
Titani K.
,
Fujimura Y.
Int. J. Hematol.68:297-310(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 1-30; 49-65; 94-97; 88-93; 193-223; 245-265; 382-385 AND 399-405 (ISOFORM 2)
tissue :
Placenta .
10.
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Cited for : FUNCTION;COFACTOR
11.
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Cited for : CHARACTERIZATION
12.
"Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae."
Koziak K.
,
Kaczmarek E.
,
Kittel A.
,
Sevigny J.
,
Blusztajn J.K.
,
Schulte Am Esch J. II
,
Imai M.
,
Guckelberger O.
,
Goepfert C.
,
Qawi I.
,
Robson S.C.
J. Biol. Chem.275:2057-2062(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : PALMITOYLATION AT CYS-13
13.
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Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-73 AND ASN-292
tissue :
Liver .
14.
"Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders."
Novarino G.
,
Fenstermaker A.G.
,
Zaki M.S.
,
Hofree M.
,
Silhavy J.L.
,
Heiberg A.D.
,
Abdellateef M.
,
Rosti B.
,
Scott E.
,
Mansour L.
,
Masri A.
,
Kayserili H.
,
Al-Aama J.Y.
,
Abdel-Salam G.M.
,
Karminejad A.
,
Kara M.
,
Kara B.
,
Bozorgmehri B.
,
Ben-Omran T.
,
Mojahedi F.
,
Mahmoud I.G.
,
Bouslam N.
,
Bouhouche A.
,
Benomar A.
,
Hanein S.
,
Raymond L.
,
Forlani S.
,
Mascaro M.
,
Selim L.
,
Shehata N.
,
Al-Allawi N.
,
Bindu P.S.
,
Azam M.
,
Gunel M.
,
Caglayan A.
,
Bilguvar K.
,
Tolun A.
,
Issa M.Y.
,
Schroth J.
,
Spencer E.G.
,
Rosti R.O.
,
Akizu N.
,
Vaux K.K.
,
Johansen A.
,
Koh A.A.
,
Megahed H.
,
Durr A.
,
Brice A.
,
Stevanin G.
,
Gabriel S.B.
,
Ideker T.
,
Gleeson J.G.
more...
Science343:506-511(2014)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT SPG64 ARG-210