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Index > Protein center > LSS(Gene name) > Human
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  • LSS (Gene name),
  • Lanosterol synthase (Protein name ),  ERG7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    LSS(OSC);
    Protein name:
    Lanosterol synthase;
    Alternative:
    2,3-epoxysqualene--lanosterol cyclase;Oxidosqualene--lanosterol cyclase(OSC;hOSC);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
    Subcellular Location:
    Endoplasmic reticulum membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    732
    Sequence:
    50:
    MTEGTCLRRR | GGPYKTEPAT | DLGRWRLNCE | RGRQTWTYLQ | DERAGREQTG | 
    100:
    LEAYALGLDT | KNYFKDLPKA | HTAFEGALNG | MTFYVGLQAE | DGHWTGDYGG | 
    150:
    PLFLLPGLLI | TCHVARIPLP | AGYREEIVRY | LRSVQLPDGG | WGLHIEDKST | 
    200:
    VFGTALNYVS | LRILGVGPDD | PDLVRARNIL | HKKGGAVAIP | SWGKFWLAVL | 
    250:
    NVYSWEGLNT | LFPEMWLFPD | WAPAHPSTLW | CHCRQVYLPM | SYCYAVRLSA | 
    300:
    AEDPLVQSLR | QELYVEDFAS | IDWLAQRNNV | APDELYTPHS | WLLRVVYALL | 
    350:
    NLYEHHHSAH | LRQRAVQKLY | EHIVADDRFT | KSISIGPISK | TINMLVRWYV | 
    400:
    DGPASTAFQE | HVSRIPDYLW | MGLDGMKMQG | TNGSQIWDTA | FAIQALLEAG | 
    450:
    GHHRPEFSSC | LQKAHEFLRL | SQVPDNPPDY | QKYYRQMRKG | GFSFSTLDCG | 
    500:
    WIVSDCTAEA | LKAVLLLQEK | CPHVTEHIPR | ERLCDAVAVL | LNMRNPDGGF | 
    550:
    ATYETKRGGH | LLELLNPSEV | FGDIMIDYTY | VECTSAVMQA | LKYFHKRFPE | 
    600:
    HRAAEIRETL | TQGLEFCRRQ | QRADGSWEGS | WGVCFTYGTW | FGLEAFACMG | 
    650:
    QTYRDGTACA | EVSRACDFLL | SRQMADGGWG | EDFESCEERR | YLQSAQSQIH | 
    700:
    NTCWAMMGLM | AVRHPDIEAQ | ERGVRCLLEK | QLPNGDWPQE | NIAGVFNKSC | 
    732:
    AISYTSYRNI | FPIWALGRFS | QLYPERALAG | HP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    KEGG:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Lanosterol synthase
    Cat.:
    E1898r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Lanosterol synthase
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    E1898h
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    96T
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    ELISA Kit for Human Lanosterol synthase
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    E1898m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Lanosterol synthase
    Cat.:
    E1898b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Lanosterol synthase
    Cat.:
    U1898m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Lanosterol synthase
    Cat.:
    U1898h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Lanosterol synthase
    Cat.:
    U1898b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Lanosterol synthase
    Cat.:
    U1898r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Lanosterol synthase
    Cat.:
    P1898Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Lanosterol synthase
    Polyclonal Antibody for Human Lanosterol synthase
    Cat.:
    P1898Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Lanosterol synthase
    Cat.:
    P1898Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Lanosterol synthase
    Monoclonal Antibody for Human Lanosterol synthase
    Monoclonal Antibody for Human Lanosterol synthase
    Monoclonal Antibody for Human Lanosterol synthase
    Protein for Human Lanosterol synthase
    Protein for Human Lanosterol synthase
    Protein for Human Lanosterol synthase
    Protein for Human Lanosterol synthase

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library."
      Baker C.H. , Matsuda S.P.T. , Liu D.R. , Corey E.J.
      Biochem. Biophys. Res. Commun.213:154-160(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;CATALYTIC ACTIVITY
      tissue: Liver.
    2. 2.
      "Molecular cloning of cDNA encoding human lanosterol synthase."
      Sung C.K. , Shibuya M. , Sankawa U. , Ebizuka Y.
      Biol. Pharm. Bull.18:1459-1461(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fetal liver.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT VAL-642
      tissue: Thalamus.
    4. 4.
      "Structure of the human lanosterol synthase gene and its analysis as a candidate for holoprosencephaly."
      Roessler E. , Mittaz L. , Du Y. , Scott H.S. , Chang J. , Rossier C. , Guipponi M. , Matsuda S.P. , Muenke M. , Antonarakis S.E.
      Hum. Genet.105:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2006-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT VAL-642
      tissue: Brain.
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-642
      tissue: Eye.
    8. 9.
      "The monotopic membrane protein human oxidosqualene cyclase is active as monomer."
      Ruf A. , Muller F. , D'Arcy B. , Stihle M. , Kusznir E. , Handschin C. , Morand O.H. , Thoma R.
      Biochem. Biophys. Res. Commun.315:247-254(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-5;CATALYTIC ACTIVITY;SUBUNIT;SUBCELLULAR LOCATION
    9. 10.
      "The human lanosterol synthase gene maps to chromosome 21q22.3."
      Young M. , Chen H. , Lalioti M.D. , Antonarakis S.E.
      Hum. Genet.97:620-624(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-630 (ISOFORM 1)
      tissue: Fetal brain.
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    12. 13.
      "Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase."
      Thoma R. , Schulz-Gasch T. , D'Arcy B. , Benz J. , Aebi J. , Dehmlow H. , Hennig M. , Stihle M. , Ruf A.
      Nature432:118-122(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEXES WITH LANOSTEROL AND RO 48-807;SUBCELLULAR LOCATION
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