ZMPSTE24 ELISA Kit for Human(Homo sapiens) | EIAab.comZMPSTE24 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ZMPSTE24(Gene name) > Human

ZMPSTE24 (Gene name),

CAAX prenyl protease 1 homolog (Protein name ), FACE1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ZMPSTE24(FACE1;STE24);

Protein name:

CAAX prenyl protease 1 homolog;

Alternative:

Prenyl protein-specific endoprotease 1;Farnesylated proteins-converting enzyme 1(FACE-1);Zinc metalloproteinase Ste24 homolog;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

475

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

475:

LFSMWHYSHP | PLLERLQALK | TMKQH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:10269

SMR:

O75844

STRING:

9606.ENSP00000361845

String:

O75844

MIM:

275210

UniGene:

Hs.132642

Pfam:

PF01435

Uniprot:

O75844

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ELISA Kit for Human CAAX prenyl protease 1 homolog

Cat.:

E10840m

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MSDS:

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Packing:

96T

ELISA Kit for Human CAAX prenyl protease 1 homolog

Cat.:

E10840h

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MSDS:

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Packing:

96T

CLIA Kit for Human CAAX prenyl protease 1 homolog

Cat.:

U10840h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human CAAX prenyl protease 1 homolog

Cat.:

U10840m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human CAAX prenyl protease 1 homolog

Cat.:

P10840Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human CAAX prenyl protease 1 homolog

Cat.:

P10840Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human CAAX prenyl protease 1 homolog

Protein for Human CAAX prenyl protease 1 homolog

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p."
Kumagai H. , Kawamura Y. , Yanagisawa K. , Komano H.
Biochim. Biophys. Acta1426:468-474(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing."
Tam A. , Nouvet F.J. , Fujimura-Kamada K. , Slunt H. , Sisodia S.S. , Michaelis S.
J. Cell Biol.142:635-649(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: B-cell.
tissue: Fetal brain.
3.

"Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins."
Freije J.M.P. , Blay P. , Pendas A.M. , Cadinanos J. , Crespo P. , Lopez-Otin C.
Genomics58:270-280(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Ovary.
4.

"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T. , Ota T. , Nishikawa T. , Hayashi K. , Suzuki Y. , Yamamoto J. , Wakamatsu A. , Kimura K. , Sakamoto K. , Hatano N. , Kawai Y. , Ishii S. , Saito K. , Kojima S. , Sugiyama T. , Ono T. , Okano K. , Yoshikawa Y. , more...
DNA Res.12:117-126(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-137
tissue: Testis.
8.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"The structural basis of ZMPSTE24-dependent laminopathies."
Quigley A. , Dong Y.Y. , Pike A.C. , Dong L. , Shrestha L. , Berridge G. , Stansfeld P.J. , Sansom M.S. , Edwards A.M. , Bountra C. , von Delft F. , Bullock A.N. , Burgess-Brown N.A. , Carpenter E.P.
Science339:1604-1607(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) IN COMPLEX WITH TETRAPEPTIDE;ACTIVE SITE;COFACTOR;METALLOPROTEASE DOMAIN;TOPOLOGY;ZINC-BINDING SITES;SUBCELLULAR LOCATION
11.

"Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia."
Agarwal A.K. , Fryns J.-P. , Auchus R.J. , Garg A.
Hum. Mol. Genet.12:1995-2001(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MADB ARG-340
12.

"Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy."
Navarro C.L. , De Sandre-Giovannoli A. , Bernard R. , Boccaccio I. , Boyer A. , Genevieve D. , Hadj-Rabia S. , Gaudy-Marqueste C. , Smitt H.S. , Vabres P. , Faivre L. , Verloes A. , Van Essen T. , Flori E. , Hennekam R. , Beemer F.A. , Laurent N. , Le Merrer M. , more...
Hum. Mol. Genet.13:2493-2503(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LTSCS
13.

"Focal segmental glomerulosclerosis in patients with mandibuloacral dysplasia owing to ZMPSTE24 deficiency."
Agarwal A.K. , Zhou X.J. , Hall R.K. , Nicholls K. , Bankier A. , Van Esch H. , Fryns J.P. , Garg A.
J. Invest. Med.54:208-213(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MADB SER-265
14.

"Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings."
Miyoshi Y. , Akagi M. , Agarwal A.K. , Namba N. , Kato-Nishimura K. , Mohri I. , Yamagata M. , Nakajima S. , Mushiake S. , Shima M. , Auchus R.J. , Taniike M. , Garg A. , Ozono K.
Clin. Genet.73:535-544(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MADB LEU-248;CHARACTERIZATION OF VARIANT MADB
15.

"Early onset mandibuloacral dysplasia due to compound heterozygous mutations in ZMPSTE24."
Ahmad Z. , Zackai E. , Medne L. , Garg A.
Am. J. Med. Genet. A152:2703-2710(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MADB LEU-248

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