Protein name:
Fibroblast growth factor receptor 1 (FGFR-1;bFGF-R-1) ;
Alternative:
Tyrosine kinase receptor CEK1 ;Basic fibroblast growth factor receptor 1 ;
Organism:
Chicken (Gallus gallus).
General Annotation
Sub Unit:
Monomer. Homodimer after ligand binding.
Function:
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2A, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2A triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Nucleus
Cytoplasm
cytosol
Cytoplasmic vesicle
After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
Protein Attributes:
50:
MFTWRCLILW | AVLVTATLSA | ARPAPTLPDQ | ALPKANIEVE | SHSAHPGDLL |
100:
QLRCRLRDDV | QSINWVRDGV | QLPENNRTRI | TGEEVEVRDA | VPEDSGLYAC |
150:
MTNSPSGSET | TYFSVNVSDA | LPSAEDDDDE | DDSSSEEKEA | DNTKPNQAVA |
200:
PYWTYPEKME | KKLHAVPAAK | TVKFKCPSGG | TPNPTLRWLK | NGKEFKPDHR |
250:
IGGYKVRYAT | WSIIMDSVVP | SDKGNYTCIV | ENKYGSINHT | YQLDVVERSP |
300:
HRPILQAGLP | ANKTVALGSN | VEFVCKVYSD | PQPHIQWLKH | IEVNGSKIGP |
350:
DNLPYVQILK | TAGVNTTDKE | MEVLHLRNVS | FEDAGEYTCL | AGNSIGISHH |
400:
SAWLTVLEAT | EQSPAMMTSP | LYLEIIIYCT | GAFLISCMVV | TVIIYKMKST |
450:
TKKTDFNSQL | AVHKLAKSIP | LRRQVTVSAD | SSSSMNSGVM | LVRPSRLSSS |
500:
GTPMLAGVSE | YELPEDPRWE | LPRDRLILGK | PLGEGCFGQV | VLAEAIGLDK |
550:
DKPNRVTKVA | VKMLKSDATE | KDLSDLISEM | EMMKMIGKHK | NIINLLGACT |
600:
QDGPLYVIVE | YASKGNLREY | LQARRPPGME | YCYNPTRIPE | EQLSFKDLVS |
650:
CAYQVARGME | YLASKKCIHR | DLAARNVLVT | EDNVMKIADF | GLARDIHHID |
700:
YYKKTTNGRL | PVKWMAPEAL | FDRIYTHQSD | VWSFGVLLWE | IFTLGGSPYP |
750:
GVPVEELFKL | LKEGHRMDKP | SNCTNELYMM | MRDCWHAVPS | QRPTFKQLVE |
800:
DLDRIVAMTS | NQEYLDLSVP | LDQYSPGFPA | TRSSTCSSGE | DSVFSHDPLP |
819:
DEPCLPRCPP | HSHGALKRH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Chicken
ELISA Kit for Chicken FGFR-1
ELISA Kit for Chicken FGFR-1
ELISA Kit for Chicken FGFR-1
ELISA Kit for Chicken FGFR-1
CLIA Kit for Chicken FGFR-1
CLIA Kit for Chicken FGFR-1
CLIA Kit for Chicken FGFR-1
CLIA Kit for Chicken FGFR-1
Polyclonal Antibody for Chicken FGFR-1
Polyclonal Antibody for Chicken FGFR-1
Polyclonal Antibody for Chicken FGFR-1
Polyclonal Antibody for Chicken FGFR-1
Monoclonal Antibody for Chicken FGFR-1
Monoclonal Antibody for Chicken FGFR-1
Monoclonal Antibody for Chicken FGFR-1
Monoclonal Antibody for Chicken FGFR-1
Protein for Chicken FGFR-1
Protein for Chicken FGFR-1
Protein for Chicken FGFR-1
Protein for Chicken FGFR-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
Pasquale E.B.
Submitted (1989-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]