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Index > Protein center > FOLR2(Gene name) > Human
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  • FOLR2 (Gene name),
  • Folate receptor beta (Protein name ),  FOLR2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    FOLR2;
    Protein name:
    Folate receptor beta(FR-beta);
    Alternative:
    Folate receptor, fetal/placental;Folate receptor 2;Placental folate-binding protein(FBP);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor Secreted
    Protein Attributes:
    Sequence length:
    255
    Sequence:
    50:
    MVWKWMPLLL | LLVCVATMCS | AQDRTDLLNV | CMDAKHHKTK | PGPEDKLHDQ | 
    100:
    CSPWKKNACC | TASTSQELHK | DTSRLYNFNW | DHCGKMEPAC | KRHFIQDTCL | 
    150:
    YECSPNLGPW | IQQVNQSWRK | ERFLDVPLCK | EDCQRWWEDC | HTSHTCKSNW | 
    200:
    HRGWDWTSGV | NKCPAGALCR | TFESYFPTPA | ALCEGLWSHS | YKVSNYSRGS | 
    250:
    GRCIQMWFDS | AQGNPNEEVA | RFYAAAMHVN | AGEMLHGTGG | LLLSLALMLQ | 
    255:
    LWLLG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    String:
    MIM:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human FR-beta
    Cat.:
    E2484h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human FR-beta
    Cat.:
    E2484m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human FR-beta
    Cat.:
    U2484h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human FR-beta
    Cat.:
    U2484m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human FR-beta
    Cat.:
    P2484Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human FR-beta
    Cat.:
    P2484Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human FR-beta
    Monoclonal Antibody for Human FR-beta
    Protein for Human FR-beta
    Protein for Human FR-beta

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene."
      Page S.T. , Owen W.C. , Price K. , Elwood P.C.
      J. Mol. Biol.229:1175-1183(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
    2. 2.
      "Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA."
      Ratnam M. , Marquardt H. , Duhring J.L. , Freisheim J.H.
      Biochemistry28:8249-8254(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;FUNCTION;TISSUE SPECIFICITY;GLYCOSYLATION;SUBCELLULAR LOCATION
      tissue: Placenta.
    3. 3.
      "Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein."
      Sadasivan E. , Cedeno M.M. , Rothenberg S.P.
      J. Biol. Chem.269:4725-4735(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    4. 4.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Cerebellum.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pancreas.
      tissue: Placenta.
    6. 6.
      "Folate coenzyme and antifolate transport proteins in normal and neoplastic cells."
      Freisheim J.H. , Price E.M. , Ratnam M.
      Adv. Enzyme Regul.29:13-26(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 68-86; 102-120 AND 173-184
    7. 7.
      "Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells."
      Antony A.C. , Kane M.A. , Portillo R.M. , Elwood P.C. , Kolhouse J.F.
      J. Biol. Chem.260:14911-14917(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    8. 8.
      "Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal."
      Yan W. , Ratnam M.
      Biochemistry34:14594-14600(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR AT ASN-230
    9. 9.
      "Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion."
      Wang J. , Shen F. , Yan W. , Wu M. , Ratnam M.
      Biochemistry36:14583-14592(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    10. 10.
      "All-trans retinoic acid is capable of inducing folate receptor beta expression in KG-1 cells."
      Xu Y. , Wang T. , Tang R. , Tang S.
      Tumor Biol.31:589-595(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY RETINOIC ACID
    11. 11.
      "Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition."
      Wibowo A.S. , Singh M. , Reeder K.M. , Carter J.J. , Kovach A.R. , Meng W. , Ratnam M. , Zhang F. , Dann C.E. III
      Proc. Natl. Acad. Sci. U.S.A.110:15180-15188(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 24-228 IN COMPLEXES WITH FOLATE AND THE ANTIFOLATES METHOTREXATE; AMINOPTERIN AND PEMETREXED;FUNCTION;GLYCOSYLATION AT ASN-195;DISULFIDE BONDS
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-236
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