Protein name:
Frizzled-3 (Fz-3;hFz3) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with VANGL2.
Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular Location:
Membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MAMTWIVFSL | WPLTVFMGHI | GGHSLFSCEP | ITLRMCQDLP | YNTTFMPNLL |
100:
NHYDQQTAAL | AMEPFHPMVN | LDCSRDFRPF | LCALYAPICM | EYGRVTLPCR |
150:
RLCQRAYSEC | SKLMEMFGVP | WPEDMECSRF | PDCDEPYPRL | VDLNLAGEPT |
200:
EGAPVAVQRD | YGFWCPRELK | IDPDLGYSFL | HVRDCSPPCP | NMYFRREELS |
250:
FARYFIGLIS | IICLSATLFT | FLTFLIDVTR | FRYPERPIIF | YAVCYMMVSL |
300:
IFFIGFLLED | RVACNASIPA | QYKASTVTQG | SHNKACTMLF | MILYFFTMAG |
350:
SVWWVILTIT | WFLAAVPKWG | SEAIEKKALL | FHASAWGIPG | TLTIILLAMN |
400:
KIEGDNISGV | CFVGLYDVDA | LRYFVLAPLC | LYVVVGVSLL | LAGIISLNRV |
450:
RIEIPLEKEN | QDKLVKFMIR | IGVFSILYLV | PLLVVIGCYF | YEQAYRGIWE |
500:
TTWIQERCRE | YHIPCPYQVT | QMSRPDLILF | LMKYLMALIV | GIPSVFWVGS |
550:
KKTCFEWASF | FHGRRKKEIV | NESRQVLQEP | DFAQSLLRDP | NTPIIRKSRG |
600:
TSTQGTSTHA | SSTQLAMVDD | QRSKAGSIHS | KVSSYHGSLH | RSRDGRYTPC |
650:
SYRGMEERLP | HGSMSRLTDH | SRHSSSHRLN | EQSRHSSIRD | LSNNPMTHIT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Polyclonal Antibody for Human Fz-3
Polyclonal Antibody for Human Fz-3
Polyclonal Antibody for Human Fz-3
Monoclonal Antibody for Human Fz-3
Monoclonal Antibody for Human Fz-3
Monoclonal Antibody for Human Fz-3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Fetal brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Fetal brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Keratinocyte .
4.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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Nat. Genet.36:40-45(2004)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 23-37
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SER-4; MET-199 AND VAL-545