GBA3 ELISA Kit for Human(Homo sapiens) | EIAab.comGBA3 ELISA Kit for Human(Homo sapiens)

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GBA3 (Gene name),

Cytosolic beta-glucosidase (Protein name ), GBA3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GBA3(CBG;CBGL1);

Protein name:

Cytosolic beta-glucosidase;

Alternative:

Cytosolic beta-glucosidase-like protein 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.

Subcellular Location:

Cytoplasm cytosol

Protein Attributes:

Sequence length:

469

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

469:

TSAKEYAKII | RNNGLEAHL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:57733

MIM:

606619

Pfam:

PF00232

UniGene:

Hs.653107

SMR:

Q9H227

Uniprot:

Q9H227

FOR

ELISA Kit for Human Cytosolic beta-glucosidase

Cat.:

E1584h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Cytosolic beta-glucosidase

Cat.:

U1584h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Cytosolic beta-glucosidase

Cat.:

P1584Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Cytosolic beta-glucosidase

Protein for Human Cytosolic beta-glucosidase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning and expression of a novel klotho-related protein."
Yahata K. , Mori K. , Arai H. , Koide S. , Ogawa Y. , Mukoyama M. , Sugawara A. , Ozaki S. , Tanaka I. , Nabeshima Y. , Nakao K.
J. Mol. Med.78:389-394(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Fetal liver.
2.

"Cloning and characterization of human liver cytosolic beta-glycosidase."
de Graaf M. , van Veen I.C. , van der Meulen-Muileman I.H. , Gerritsen W.R. , Pinedo H.M. , Haisma H.J.
Biochem. J.356:907-910(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
tissue: Liver.
3.

"Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides."
Berrin J.-G. , McLauchlan W.R. , Needs P. , Williamson G. , Puigserver A. , Kroon P.A. , Juge N.
Eur. J. Biochem.269:249-258(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;BLOCKAGE OF N-TERMINUS;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
tissue: Liver.
4.

Hays W.S. , VanderJagt D.J. , Glew R.H. , Johnston D.E.
Submitted (2000-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
5.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Small intestine.
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Kidney.
tissue: Liver.
7.

"Substrate (aglycone) specificity of human cytosolic beta-glucosidase."
Berrin J.-G. , Czjzek M. , Kroon P.A. , McLauchlan W.R. , Puigserver A. , Williamson G. , Juge N.
Biochem. J.373:41-48(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF VAL-168; PHE-225 AND TYR-308
8.

"Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans."
Nemeth K. , Plumb G.W. , Berrin J.-G. , Juge N. , Jacob R. , Naim H.Y. , Williamson G. , Swallow D.M. , Kroon P.A.
Eur. J. Nutr.42:29-42(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.

"Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase."
Hayashi Y. , Okino N. , Kakuta Y. , Shikanai T. , Tani M. , Narimatsu H. , Ito M.
J. Biol. Chem.282:30889-30900(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) IN COMPLEX WITH GLUCOSE AND GALACTOSE;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF GLU-165 AND GLU-373
10.

"The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase."
Tribolo S. , Berrin J.G. , Kroon P.A. , Czjzek M. , Juge N.
J. Mol. Biol.370:964-975(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS)
11.

"Crystal structure of the covalent intermediate of human cytosolic beta-glucosidase."
Noguchi J. , Hayashi Y. , Baba Y. , Okino N. , Kimura M. , Ito M. , Kakuta Y.
Biochem. Biophys. Res. Commun.374:549-552(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH GLUCOSE;MUTAGENESIS OF GLU-165
12.

"Mutations in the gene encoding cytosolic beta-glucosidase in Gaucher disease."
Beutler E. , Beutler L. , West C.
J. Lab. Clin. Med.144:65-68(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-106

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