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Index > Protein center > GBA3(Gene name) > Human
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  • GBA3 (Gene name),
  • Cytosolic beta-glucosidase (Protein name ),  GBA3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    GBA3(CBG;CBGL1);
    Protein name:
    Cytosolic beta-glucosidase;
    Alternative:
    Cytosolic beta-glucosidase-like protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.
    Subcellular Location:
    Cytoplasm cytosol
    Protein Attributes:
    Sequence length:
    469
    Sequence:
    50:
    MAFPAGFGWA | AATAAYQVEG | GWDADGKGPC | VWDTFTHQGG | ERVFKNQTGD | 
    100:
    VACGSYTLWE | EDLKCIKQLG | LTHYRFSLSW | SRLLPDGTTG | FINQKGIDYY | 
    150:
    NKIIDDLLKN | GVTPIVTLYH | FDLPQTLEDQ | GGWLSEAIIE | SFDKYAQFCF | 
    200:
    STFGDRVKQW | ITINEANVLS | VMSYDLGMFP | PGIPHFGTGG | YQAAHNLIKA | 
    250:
    HARSWHSYDS | LFRKKQKGMV | SLSLFAVWLE | PADPNSVSDQ | EAAKRAITFH | 
    300:
    LDLFAKPIFI | DGDYPEVVKS | QIASMSQKQG | YPSSRLPEFT | EEEKKMIKGT | 
    350:
    ADFFAVQYYT | TRLIKYQENK | KGELGILQDA | EIEFFPDPSW | KNVDWIYVVP | 
    400:
    WGVCKLLKYI | KDTYNNPVIY | ITENGFPQSD | PAPLDDTQRW | EYFRQTFQEL | 
    450:
    FKAIQLDKVN | LQVYCAWSLL | DNFEWNQGYS | SRFGLFHVDF | EDPARPRVPY | 
    469:
    TSAKEYAKII | RNNGLEAHL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    MIM:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cytosolic beta-glucosidase
    Cat.:
    E1584h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Cytosolic beta-glucosidase
    Cat.:
    U1584h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Cytosolic beta-glucosidase
    Cat.:
    P1584Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cytosolic beta-glucosidase
    Protein for Human Cytosolic beta-glucosidase

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Molecular cloning and expression of a novel klotho-related protein."
      Yahata K. , Mori K. , Arai H. , Koide S. , Ogawa Y. , Mukoyama M. , Sugawara A. , Ozaki S. , Tanaka I. , Nabeshima Y. , Nakao K.
      J. Mol. Med.78:389-394(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Fetal liver.
    2. 2.
      "Cloning and characterization of human liver cytosolic beta-glycosidase."
      de Graaf M. , van Veen I.C. , van der Meulen-Muileman I.H. , Gerritsen W.R. , Pinedo H.M. , Haisma H.J.
      Biochem. J.356:907-910(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
      tissue: Liver.
    3. 3.
      "Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides."
      Berrin J.-G. , McLauchlan W.R. , Needs P. , Williamson G. , Puigserver A. , Kroon P.A. , Juge N.
      Eur. J. Biochem.269:249-258(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;BLOCKAGE OF N-TERMINUS;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
      tissue: Liver.
    4. 4.
      Hays W.S. , VanderJagt D.J. , Glew R.H. , Johnston D.E.
      Submitted (2000-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    5. 5.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Small intestine.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Kidney.
      tissue: Liver.
    7. 7.
      "Substrate (aglycone) specificity of human cytosolic beta-glucosidase."
      Berrin J.-G. , Czjzek M. , Kroon P.A. , McLauchlan W.R. , Puigserver A. , Williamson G. , Juge N.
      Biochem. J.373:41-48(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF VAL-168; PHE-225 AND TYR-308
    8. 8.
      "Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans."
      Nemeth K. , Plumb G.W. , Berrin J.-G. , Juge N. , Jacob R. , Naim H.Y. , Williamson G. , Swallow D.M. , Kroon P.A.
      Eur. J. Nutr.42:29-42(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    9. 9.
      "Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase."
      Hayashi Y. , Okino N. , Kakuta Y. , Shikanai T. , Tani M. , Narimatsu H. , Ito M.
      J. Biol. Chem.282:30889-30900(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) IN COMPLEX WITH GLUCOSE AND GALACTOSE;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF GLU-165 AND GLU-373
    10. 10.
      "The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase."
      Tribolo S. , Berrin J.G. , Kroon P.A. , Czjzek M. , Juge N.
      J. Mol. Biol.370:964-975(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS)
    11. 11.
      "Crystal structure of the covalent intermediate of human cytosolic beta-glucosidase."
      Noguchi J. , Hayashi Y. , Baba Y. , Okino N. , Kimura M. , Ito M. , Kakuta Y.
      Biochem. Biophys. Res. Commun.374:549-552(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH GLUCOSE;MUTAGENESIS OF GLU-165
    12. 12.
      "Mutations in the gene encoding cytosolic beta-glucosidase in Gaucher disease."
      Beutler E. , Beutler L. , West C.
      J. Lab. Clin. Med.144:65-68(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-106
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