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Index > Protein center > Gnas(Gene name) > Rat
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  • Gnas (Gene name),
  • Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Protein name ),  GNAS1_RAT from NCBI database.
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  • Gene name:
    Gnas(Gnas1);
    Protein name:
    Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;
    Alternative:
    Extra large alphas protein(XLalphas);Adenylate cyclase-stimulating G alpha protein;G-alpha-8;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts through its N-terminal region with ALEX which is produced from the same locus in a different open reading frame. This interaction may inhibit its adenylyl cyclase-stimulating activity.
    Function:
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms.
    Subcellular Location:
    Cell membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    1144
    Sequence:
    50:
    MGMLNCLHGN | NMSGQHDIPP | EVGDQPEQEP | LEAQGAAAPG | AGVGPAEEME | 
    100:
    TEPSNNEPIP | DETDSEVCGP | PEDSKSDIQS | PSQAFEEVQV | GGDYSPPPEE | 
    150:
    AMPFEIQQPS | LGDFWPTLEQ | PGPSGTPSGI | KAFNPAILEP | GTPTGAHPGL | 
    200:
    GAYSPPPEEA | MPFEFNEPAQ | EDRCQPPLQV | PDLAPGGPEA | WVSRALPAEP | 
    250:
    GNLGFENTGF | REDYSPPPEE | SVPFQLDGEE | FGGDSPPPGL | PRVTPQIGIG | 
    300:
    GEFPTVAVPS | TLCLAPAANA | PPLWVQGAIG | RPFREAVRSP | NFAYDISPME | 
    350:
    ITRPLLEIGR | ASTGVDDDTA | VNMDSPPIAS | DGPPIEVSGA | PVKSEHAKRP | 
    400:
    PLERQAAETG | NSPISSTTAE | EAKVPSLERG | EGSPTQPETV | HIKPAPVAES | 
    450:
    GTDSSKADPD | SATHAVLQIG | PEEVGGVPTM | PTDLPPASED | AGPDVRAEPD | 
    500:
    GGTAPATPAE | SEDNREPAAA | AAAEPAAEPA | AEPAAEPAAE | PAAEPAAEAV | 
    550:
    PDTEAESASG | AVPDTQEEPA | AAAASATPAE | PAARAAPVTP | TEPATRAVPS | 
    600:
    ARAHPAAGAV | PGASAMSAAA | RAAAARAAYA | GPLVWGARSL | SATPAARASL | 
    650:
    PARAAAAARA | ASAARAVAAG | RSASAAPSRA | HLRPPSPEIQ | VADPPTPRPA | 
    700:
    PRPSAWPDKY | ERGRSCCRYE | AASGICEIES | SSDESEEGAT | GCFQWLLRRN | 
    750:
    RRPGQPRSHT | VGSNPVRNFF | ARAFGSCFGL | SECTRSRSLS | PGKAKDPMEE | 
    800:
    RRKQMRKEAM | EMREQKRADK | KRSKLIDKQL | EEEKMDYMCT | HRLLLLGAGE | 
    850:
    SGKSTIVKQM | RILHVNGFNG | EGGEEDPQAA | RSNSDGEKAT | KVQDIKNNLK | 
    900:
    EAIETIVAAM | SNLVPPVELA | NPENQFRVDY | ILSVMNVPNF | DFPPEFYEHA | 
    950:
    KALWEDEGVR | ACYERSNEYQ | LIDCAQYFLD | KIDVIKQADY | VPSDQDLPRC | 
    1000:
    RVLTSGIFET | KFQVDKVNFH | MFDVGGQRDE | RRKWIQCFND | VTAIIFVVAS | 
    1050:
    SSYNMVIRED | NQTNRLQEAL | NLFKSIWNNR | WLRTISVILF | LNKQDLLAEK | 
    1100:
    VLAGKSKIED | YFPEFARYTT | PEDATPEPGE | DPRVTRAKYF | IRDEFLRIST | 
    1144:
    ASGDGRHYCY | PHFTCAVDTE | NIRRVFNDCR | DIIQRMHLRQ | YELL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288h
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    96T
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    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288d
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288p
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288h
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288h
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    E14288r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    ELISA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    Packing:
    96T
    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    U14288m
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    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    U14288b
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    96T
    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    CLIA Kit for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    96T
    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    P14288Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    P14288Rb-r
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    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    P14288Rb-h
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    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    P14288Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    P14288Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    P14288Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    P14288Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    P14288Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Cat.:
    P14288Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Polyclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
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    P14288Rb-h
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    Packing:
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    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Monoclonal Antibody for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
    Protein for Rat Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

    R&D Technical Data
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    Precision
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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 284-1144;TISSUE SPECIFICITY
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    4. 4.
      "Characterization of the extra-large G protein alpha-subunit XLalphas. I. Tissue distribution and subcellular localization."
      Pasolli H.A. , Klemke M. , Kehlenbach R.H. , Wang Y. , Huttner W.B.
      J. Biol. Chem.275:33622-33632(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    5. 5.
      "Characterization of the extra-large G protein alpha-subunit XLalphas. II. Signal transduction properties."
      Klemke M. , Pasolli H.A. , Kehlenbach R.H. , Offermanns S. , Schultz G. , Huttner W.B.
      J. Biol. Chem.275:33633-33640(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;MUTAGENESIS OF GLN-977
    6. 6.
      "Two overlapping reading frames in a single exon encode interacting proteins -- a novel way of gene usage."
      Klemke M. , Kehlenbach R.H. , Huttner W.B.
      EMBO J.20:3849-3860(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ALEX
    7. 7.
      "XL alpha-s, the extra-long form of the alpha subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex."
      Abramowitz J. , Grenet D. , Birnbaumer M. , Torres H.N. , Birnbaumer L.
      Proc. Natl. Acad. Sci. U.S.A.101:8366-8371(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION
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