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Index > Protein center > GCLC(Gene name) > Human
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  • GCLC (Gene name),
  • Glutamate--cysteine ligase catalytic subunit (Protein name ),  GSH1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    GCLC(GLCL;GLCLC);
    Protein name:
    Glutamate--cysteine ligase catalytic subunit;
    Alternative:
    Gamma-ECS;GCS heavy chain;Gamma-glutamylcysteine synthetase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of a catalytic heavy chain and a regulatory light chain.
    Function:
    N/A
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    637
    Sequence:
    50:
    MGLLSQGSPL | SWEETKRHAD | HVRRHGILQF | LHIYHAVKDR | HKDVLKWGDE | 
    100:
    VEYMLVSFDH | ENKKVRLVLS | GEKVLETLQE | KGERTNPNHP | TLWRPEYGSY | 
    150:
    MIEGTPGQPY | GGTMSEFNTV | EANMRKRRKE | ATSILEENQA | LCTITSFPRL | 
    200:
    GCPGFTLPEV | KPNPVEGGAS | KSLFFPDEAI | NKHPRFSTLT | RNIRHRRGEK | 
    250:
    VVINVPIFKD | KNTPSPFIET | FTEDDEASRA | SKPDHIYMDA | MGFGMGNCCL | 
    300:
    QVTFQACSIS | EARYLYDQLA | TICPIVMALS | AASPFYRGYV | SDIDCRWGVI | 
    350:
    SASVDDRTRE | ERGLEPLKNN | NYRISKSRYD | SIDSYLSKCG | EKYNDIDLTI | 
    400:
    DKEIYEQLLQ | EGIDHLLAQH | VAHLFIRDPL | TLFEEKIHLD | DANESDHFEN | 
    450:
    IQSTNWQTMR | FKPPPPNSDI | GWRVEFRPME | VQLTDFENSA | YVVFVVLLTR | 
    500:
    VILSYKLDFL | IPLSKVDENM | KVAQKRDAVL | QGMFYFRKDI | CKGGNAVVDG | 
    550:
    CGKAQNSTEL | AAEEYTLMSI | DTIINGKEGV | FPGLIPILNS | YLENMEVDVD | 
    600:
    TRCSILNYLK | LIKKRASGEL | MTVARWMREF | IANHPDYKQD | SVITDEMNYS | 
    637:
    LILKCNQIAN | ELCECPELLG | SAFRKVKYSG | SKTDSSN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    MIM:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Glutamate--cysteine ligase catalytic subunit
    Cat.:
    E1410h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Glutamate--cysteine ligase catalytic subunit
    Cat.:
    E1410r
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Glutamate--cysteine ligase catalytic subunit
    Cat.:
    E1410m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Glutamate--cysteine ligase catalytic subunit
    Cat.:
    U1410r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Glutamate--cysteine ligase catalytic subunit
    Cat.:
    U1410m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Glutamate--cysteine ligase catalytic subunit
    Cat.:
    U1410h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Glutamate--cysteine ligase catalytic subunit
    Cat.:
    P1410Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Glutamate--cysteine ligase catalytic subunit
    Cat.:
    P1410Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Glutamate--cysteine ligase catalytic subunit
    Cat.:
    P1410Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Glutamate--cysteine ligase catalytic subunit
    Monoclonal Antibody for Human Glutamate--cysteine ligase catalytic subunit
    Monoclonal Antibody for Human Glutamate--cysteine ligase catalytic subunit
    Protein for Human Glutamate--cysteine ligase catalytic subunit
    Protein for Human Glutamate--cysteine ligase catalytic subunit
    Protein for Human Glutamate--cysteine ligase catalytic subunit

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    References
    1. 1.
      "Cloning and nucleotide sequence of a full-length cDNA for human liver gamma-glutamylcysteine synthetase."
      Gipp J.J. , Chang C. , Mulcahy R.T.
      Biochem. Biophys. Res. Commun.185:29-35(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    2. 2.
      NIEHS SNPs program
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SER-462
    3. 3.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Hippocampus.
      tissue: Testis.
    5. 5.
      "Identification of a putative antioxidant response element in the 5'-flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene."
      Mulcahy R.T. , Gipp J.J.
      Biochem. Biophys. Res. Commun.209:227-233(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27
      tissue: Foreskin fibroblast.
    6. 6.
      "The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency."
      Beutler E. , Gelbart T. , Kondo T. , Matsunaga A.T.
      Blood94:2890-2894(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 341-440;VARIANT HAGGSD LEU-370
    7. 7.
      "Expression and purification of human gamma-glutamylcysteine synthetase."
      Misra I. , Griffith O.W.
      Protein Expr. Purif.13:268-276(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    8. 8.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5 AND SER-8;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia."
      Ristoff E. , Augustson C. , Geissler J. , de Rijk T. , Carlsson K. , Luo J.-L. , Andersson K. , Weening R.S. , van Zwieten R. , Larsson A. , Roos D.
      Blood95:2193-2196(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HAGGSD LEU-158
    11. 11.
      "A novel missense mutation in the gamma-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production."
      Hamilton D. , Wu J.H. , Alaoui-Jamali M. , Batist G.
      Blood102:725-730(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HAGGSD CYS-127
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