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Index > Protein center > HDAC7(Gene name) > Human
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  • HDAC7 (Gene name),
  • Histone deacetylase 7 (Protein name ),  HDAC7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HDAC7(HDAC7A);
    Protein name:
    Histone deacetylase 7(HD7);
    Alternative:
    Histone deacetylase 7A(HD7a);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C (By similarity). Interacts with KAT5 and EDNRA. Interacts with KDM5B.
    Function:
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.
    Subcellular Location:
    Nucleus Cytoplasm In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
    Protein Attributes:
    Sequence length:
    952
    Sequence:
    50:
    MDLRVGQRPP | VEPPPEPTLL | ALQRPQRLHH | HLFLAGLQQQ | RSVEPMRLSM | 
    100:
    DTPMPELQVG | PQEQELRQLL | HKDKSKRSAV | ASSVVKQKLA | EVILKKQQAA | 
    150:
    LERTVHPNSP | GIPYRTLEPL | ETEGATRSML | SSFLPPVPSL | PSDPPEHFPL | 
    200:
    RKTVSEPNLK | LRYKPKKSLE | RRKNPLLRKE | SAPPSLRRRP | AETLGDSSPS | 
    250:
    SSSTPASGCS | SPNDSEHGPN | PILGSEALLG | QRLRLQETSV | APFALPTVSL | 
    300:
    LPAITLGLPA | PARADSDRRT | HPTLGPRGPI | LGSPHTPLFL | PHGLEPEAGG | 
    350:
    TLPSRLQPIL | LLDPSGSHAP | LLTVPGLGPL | PFHFAQSLMT | TERLSGSGLH | 
    400:
    WPLSRTRSEP | LPPSATAPPP | PGPMQPRLEQ | LKTHVQVIKR | SAKPSEKPRL | 
    450:
    RQIPSAEDLE | TDGGGPGQVV | DDGLEHRELG | HGQPEARGPA | PLQQHPQVLL | 
    500:
    WEQQRLAGRL | PRGSTGDTVL | LPLAQGGHRP | LSRAQSSPAA | PASLSAPEPA | 
    550:
    SQARVLSSSE | TPARTLPFTT | GLIYDSVMLK | HQCSCGDNSR | HPEHAGRIQS | 
    600:
    IWSRLQERGL | RSQCECLRGR | KASLEELQSV | HSERHVLLYG | TNPLSRLKLD | 
    650:
    NGKLAGLLAQ | RMFVMLPCGG | VGVDTDTIWN | ELHSSNAARW | AAGSVTDLAF | 
    700:
    KVASRELKNG | FAVVRPPGHH | ADHSTAMGFC | FFNSVAIACR | QLQQQSKASK | 
    750:
    ILIVDWDVHH | GNGTQQTFYQ | DPSVLYISLH | RHDDGNFFPG | SGAVDEVGAG | 
    800:
    SGEGFNVNVA | WAGGLDPPMG | DPEYLAAFRI | VVMPIAREFS | PDLVLVSAGF | 
    850:
    DAAEGHPAPL | GGYHVSAKCF | GYMTQQLMNL | AGGAVVLALE | GGHDLTAICD | 
    900:
    ASEACVAALL | GNRVDPLSEE | GWKQKPNLNA | IRSLEAVIRV | HSKYWGCMQR | 
    950:
    LASCPDSWVP | RVPGADKEEV | EAVTALASLS | VGILAEDRPS | EQLVEEEEPM | 
    952:
    NL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    UniGene:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human HD7
    Cat.:
    E11378r
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    ELISA Kit for Human HD7
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    ELISA Kit for Human HD7
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    E11378h
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    MSDS:
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    CLIA Kit for Human HD7
    Cat.:
    U11378h
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    Packing:
    96T
    CLIA Kit for Human HD7
    Cat.:
    U11378m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human HD7
    MSDS:
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    Polyclonal Antibody for Human HD7
    Polyclonal Antibody for Human HD7
    Polyclonal Antibody for Human HD7
    Cat.:
    P11378Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human HD7
    Monoclonal Antibody for Human HD7
    Monoclonal Antibody for Human HD7
    Protein for Human HD7
    Protein for Human HD7
    Protein for Human HD7

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    Precision
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    Linearity
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    References
    1. 1.
      "A novel class II HDAC is associated with the transcriptional homeodomain repressor CCAAT displacement protein."
      Li S. , Fischle W. , Verdin E. , Walsh M.J.
      Submitted (2000-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Cervix carcinoma.
    2. 2.
      "Genomic organization of the human histone deacetylase 7 gene."
      Petrie K. , Zelent A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 5)
    3. 3.
      "Homo sapiens histone deacetylase 7A (HDAC7A), transcript variant 3."
      Zhi Y. , Su E.W.
      Submitted (2003-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5; 6; 8 AND 9);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 220-952 (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 651-952
      tissue: Embryo.
      tissue: Mammary gland.
      tissue: Placenta.
      tissue: Spleen.
      tissue: Teratocarcinoma.
      tissue: Thymus.
    6. 6.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 242-952 (ISOFORM 1)
      tissue: B-cell.
      tissue: Colon.
      tissue: PNS.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 75-952 (ISOFORM 1)
      tissue: Uterus.
    10. 10.
      "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling."
      Lee H.-J. , Chun M. , Kandror K.V.
      J. Biol. Chem.276:16597-16600(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH EDNRA
    11. 11.
      "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo."
      Fischle W. , Dequiedt F. , Fillion M. , Hendzel M.J. , Voelter W. , Verdin E.
      J. Biol. Chem.276:35826-35835(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC3
    12. 12.
      "Signal transduction and transcription factor modification during reactivation of Epstein-Barr virus from latency."
      Bryant H. , Farrell P.J.
      J. Virol.76:10290-10298(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KAT5
    14. 14.
      "New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases."
      Dequiedt F. , Martin M. , Von Blume J. , Vertommen D. , Lecomte E. , Mari N. , Heinen M.F. , Bachmann M. , Twizere J.C. , Huang M.C. , Rider M.H. , Piwnica-Worms H. , Seufferlein T. , Kettmann R.
      Mol. Cell. Biol.26:7086-7102(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-155 AND SER-181;MUTAGENESIS OF LEU-150; SER-155; SER-181; SER-358 AND SER-486
    15. 15.
      "Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2."
      von Blume J. , Knippschild U. , Dequiedt F. , Giamas G. , Beck A. , Auer A. , Van Lint J. , Adler G. , Seufferlein T.
      EMBO J.26:4619-4633(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-181
    16. 16.
      "Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases."
      Barrett A. , Santangelo S. , Tan K. , Catchpole S. , Roberts K. , Spencer-Dene B. , Hall D. , Scibetta A. , Burchell J. , Verdin E. , Freemont P. , Taylor-Papadimitriou J.
      Int. J. Cancer121:265-275(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KDM5B
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109; SER-283; THR-286 AND SER-486;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-486;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    20. 20.
      "Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases."
      Harrison B.C. , Huynh K. , Lundgaard G.L. , Helmke S.M. , Perryman M.B. , McKinsey T.A.
      FEBS Lett.584:1103-1110(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
    21. 21.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181; SER-283 AND THR-286;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    22. 22.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181 AND SER-486;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      "Beta-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells."
      Satow R. , Shitashige M. , Jigami T. , Fukami K. , Honda K. , Kitabayashi I. , Yamada T.
      Gastroenterology142:572-581(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PML
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    25. 25.
      "Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity."
      Schuetz A. , Min J. , Allali-Hassani A. , Schapira M. , Shuen M. , Loppnau P. , Mazitschek R. , Kwiatkowski N.P. , Lewis T.A. , Maglathin R.L. , McLean T.H. , Bochkarev A. , Plotnikov A.N. , Vedadi M. , Arrowsmith C.H.
      J. Biol. Chem.283:11355-11363(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 482-903;ZINC-BINDING SITES;MUTAGENESIS OF HIS-843
    26. 26.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-43
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