ALAD ELISA Kit for Human(Homo sapiens) | EIAab.comALAD ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ALAD(Gene name) > Human

ALAD (Gene name),

Delta-aminolevulinic acid dehydratase (Protein name ), HEM2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ALAD;

Protein name:

Delta-aminolevulinic acid dehydratase(ALADH);

Alternative:

Porphobilinogen synthase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homooctamer; active form. Homohexamer; low activity form.

Function:

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.

Subcellular Location:

Protein Attributes:

Sequence length:

330

Sequence:

50:

100:

150:

200:

250:

300:

330:

LEAMTAFRRA | GADIIITYYT | PQLLQWLKEE |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P13716

STRING:

9606.ENSP00000386284

Pfam:

PF00490

UniGene:

Hs.1227

String:

P13716

KEGG:

hsa:210

MIM:

125270

Uniprot:

P13716

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ELISA Kit for Human ALADH

Cat.:

E2082h

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96T

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ELISA Kit for Human ALADH

Cat.:

E2082r

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96T

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ELISA Kit for Human ALADH

Cat.:

E2082m

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96T

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ELISA Kit for Human ALADH

Cat.:

E2082b

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Packing:

96T

CLIA Kit for Human ALADH

Cat.:

U2082b

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96T

CLIA Kit for Human ALADH

Cat.:

U2082r

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96T

CLIA Kit for Human ALADH

Cat.:

U2082m

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96T

CLIA Kit for Human ALADH

Cat.:

U2082h

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96T

Polyclonal Antibody for Human ALADH

Cat.:

P2082Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human ALADH

Cat.:

P2082Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human ALADH

Cat.:

P2082Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human ALADH

Protein for Human ALADH

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Human delta-aminolevulinate dehydratase: nucleotide sequence of a full-length cDNA clone."
Wetmur J.G. , Bishop D.F. , Cantelmo C. , Desnick R.J.
Proc. Natl. Acad. Sci. U.S.A.83:7703-7707(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"RsaI polymorphism in the human delta-aminolevulinate dehydratase gene at 9q34."
Wetmur J.G.
Nucleic Acids Res.19:4307-4307(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Liver.
3.

"Cloning and expression of the defective genes from a patient with delta-aminolevulinate dehydratase porphyria."
Ishida N. , Fujita H. , Fukuda Y. , Noguchi T. , Doss M. , Kappas A. , Sassa S.
J. Clin. Invest.89:1431-1437(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS AHEPP TRP-240 AND THR-274
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Brain.
tissue: Tongue.
5.

NIEHS SNPs program
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ASN-59
6.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Placenta.
8.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-17
tissue: Platelet.
9.

"Identification of lysine at the active site of human 5-aminolevulinate dehydratase."
Gibbs P.N.B. , Jordan P.M.
Biochem. J.236:447-451(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITE
10.

"The molecular mechanism of lead inhibition of human porphobilinogen synthase."
Jaffe E.K. , Martins J. , Li J. , Kervinen J. , Dunbrack R.L. Jr.
J. Biol. Chem.276:1531-1537(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;COFACTOR;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF CYS-122; CYS-124; HIS-131; CYS-132 AND CYS-223
11.

"Allosteric inhibition of human porphobilinogen synthase."
Lawrence S.H. , Ramirez U.D. , Selwood T. , Stith L. , Jaffe E.K.
J. Biol. Chem.284:35807-35817(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBUNIT;ENZYME REGULATION
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"The crystal structure of human Ala-dehydratase."
Mills-Davies N.L. , Thompson D. , Cooper J.B. , Shoolingin-Jordan P.M.
Submitted (1998-10) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.83 ANGSTROMS) IN COMPLEX WITH PORPHOBILINOGEN AND ZINC IONS
14.

"Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase."
Breinig S. , Kervinen J. , Stith L. , Wasson A.S. , Fairman R. , Wlodawer A. , Zdanov A. , Jaffe E.K.
Nat. Struct. Biol.10:757-763(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF MUTANT LEU-12 IN COMPLEX WITH SUBSTRATE ANALOG;SUBUNIT;IDENTIFICATION BY MASS SPECTROMETRY;CATALYTIC ACTIVITY;ENZYME REGULATION
15.

"Molecular characterization of the human delta-aminolevulinate dehydratase 2 (ALAD2) allele: implications for molecular screening of individuals for genetic susceptibility to lead poisoning."
Wetmur J.G. , Kaya A.H. , Plewinska M. , Desnick R.J.
Am. J. Hum. Genet.49:757-763(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-59
16.

"Delta-aminolevulinate dehydratase deficient porphyria: identification of the molecular lesions in a severely affected homozygote."
Plewinska M. , Thunell S. , Holmberg L. , Wetmur J.G. , Desnick R.J.
Am. J. Hum. Genet.49:167-174(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHEPP ARG-133 AND MET-275
17.

"Cloning and expression of the defective genes in delta-aminolevulinate dehydratase porphyria: compound heterozygosity in this hereditary liver disease."
Sassa S. , Ishida N. , Fujita H. , Fukuda Y. , Noguchi T. , Doss M. , Kappas A.
Trans. Assoc. Am. Physicians105:250-259(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHEPP TRP-240 AND THR-274;CHARACTERIZATION OF VARIANTS AHEPP TRP-240 AND THR-274
18.

"A novel mutation of delta-aminolaevulinate dehydratase in a healthy child with 12% erythrocyte enzyme activity."
Akagi R. , Yasui Y. , Harper P. , Sassa S.
Br. J. Haematol.106:931-937(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-12;CHARACTERIZATION OF VARIANT LEU-12
19.

"Novel molecular defects of the delta-aminolevulinate dehydratase gene in a patient with inherited acute hepatic porphyria."
Akagi R. , Shimizu R. , Furuyama K. , Doss M.O. , Sassa S.
Hepatology31:704-708(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AHEPP MET-153;CHARACTERIZATION OF VARIANT AHEPP MET-153
20.

"Dual gene defects involving delta-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient."
Akagi R. , Inoue R. , Muranaka S. , Tahara T. , Taketani S. , Anderson K.E. , Phillips J.D. , Sassa S.
Br. J. Haematol.132:237-243(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-12
21.

"ALAD porphyria is a conformational disease."
Jaffe E.K. , Stith L.
Am. J. Hum. Genet.80:329-337(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS AHEPP ARG-133; MET-153; TRP-240; THR-274 AND MET-275;CHARACTERIZATION OF VARIANTS LEU-12 AND ASN-59

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