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Index > Protein center > HEY1(Gene name) > Human
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  • HEY1 (Gene name),
  • Hairy/enhancer-of-split related with YRPW motif protein 1 (Protein name ),  HEY1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    HEY1(BHLHB31;CHF2;HERP2;HESR1;HRT1);
    Protein name:
    Hairy/enhancer-of-split related with YRPW motif protein 1;
    Alternative:
    Class B basic helix-loop-helix protein 31(bHLHb31);Cardiovascular helix-loop-helix factor 2(CHF-2);Hairy and enhancer of split-related protein 1(HESR-1);HES-related repressor protein 1;Hairy-related transcription factor 1(HRT-1;hHRT1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Self-associates (By similarity). Interacts with HES1 and HEYL (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with GATA4 and GATA6 (By similarity). Interacts with CCDC89/BOIP.
    Function:
    Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    304
    Sequence:
    50:
    MKRAHPEYSS | SDSELDETIE | VEKESADENG | NLSSALGSMS | PTTSSQILAR | 
    100:
    KRRRGIIEKR | RRDRINNSLS | ELRRLVPSAF | EKQGSAKLEK | AEILQMTVDH | 
    150:
    LKMLHTAGGK | GYFDAHALAM | DYRSLGFREC | LAEVARYLSI | IEGLDASDPL | 
    200:
    RVRLVSHLNN | YASQREAASG | AHAGLGHIPW | GTVFGHHPHI | AHPLLLPQNG | 
    250:
    HGNAGTTASP | TEPHHQGRLG | SAHPEAPALR | APPSGSLGPV | LPVVTSASKL | 
    300:
    SPPLLSSVAS | LSAFPFSFGS | FHLLSPNALS | PSAPTQAANL | GKPYRPWGTE | 
    304:
    IGAF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    UniGene:
    MIM:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    ELISA Kit for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    ELISA Kit for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    ELISA Kit for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    CLIA Kit for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    CLIA Kit for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    CLIA Kit for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    CLIA Kit for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    Polyclonal Antibody for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    Polyclonal Antibody for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    Polyclonal Antibody for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    Polyclonal Antibody for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    Monoclonal Antibody for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    Monoclonal Antibody for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    Monoclonal Antibody for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    Monoclonal Antibody for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    Protein for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    Protein for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    Protein for Human Hairy/enhancer-of-split related with YRPW motif protein 1
    Protein for Human Hairy/enhancer-of-split related with YRPW motif protein 1

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    Precision
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    Linearity
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    References
    1. 1.
      "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split."
      Kokubo H. , Lun Y. , Johnson R.L.
      Biochem. Biophys. Res. Commun.260:459-465(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis."
      Leimeister C. , Externbrinck A. , Klamt B. , Gessler M.
      Mech. Dev.85:173-177(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family."
      Steidl C. , Leimeister C. , Klamt B. , Maier M. , Nanda I. , Dixon M. , Clarke R. , Schmid M. , Gessler M.
      Genomics66:195-203(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system."
      Chin M.T. , Maemura K. , Fukumoto S. , Jain M.K. , Layne M.D. , Watanabe M. , Hsieh C.-M. , Lee M.-E.
      J. Biol. Chem.275:6381-6387(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "The HERP repressors, novel partners for HES/hairy in notch signaling."
      Iso T. , Sartorelli V. , Poizat C. , Chen T. , Sucov H.M. , Chung G. , Wu H.-Y. , Kedes L. , Hamamori Y.
      Submitted (2000-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    6. 6.
      "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."
      Nakagawa O. , McFadden D.G. , Nakagawa M. , Yanagisawa H. , Hu T. , Srivastava D. , Olson E.N.
      Proc. Natl. Acad. Sci. U.S.A.97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;DNA-BINDING
    7. 7.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Placenta.
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    11. 12.
      "Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."
      Kathiriya I.S. , King I.N. , Murakami M. , Nakagawa M. , Astle J.M. , Gardner K.A. , Gerard R.D. , Olson E.N. , Srivastava D. , Nakagawa O.
      J. Biol. Chem.279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 13.
      "Crystal structure of hypothetical protein MS0332."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2009-02) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 111-167
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