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Index > Protein center > HEYL(Gene name) > Human
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  • HEYL (Gene name),
  • Hairy/enhancer-of-split related with YRPW motif-like protein (Protein name ),  HEYL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HEYL(BHLHB33;HRT3);
    Protein name:
    Hairy/enhancer-of-split related with YRPW motif-like protein(hHeyL);
    Alternative:
    Hairy-related transcription factor 3(HRT-3;hHRT3);Class B basic helix-loop-helix protein 33(bHLHb33);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Self-associates (By similarity). Interacts with GATA4, GATA6, HES1, HEY1 and HEY2 (By similarity). Interacts with HDAC1, NCOR1 and SIN3A.
    Function:
    Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    328
    Sequence:
    50:
    MKRPKEPSGS | DGESDGPIDV | GQEGQLSQMA | RPLSTPSSSQ | MQARKKHRGI | 
    100:
    IEKRRRDRIN | SSLSELRRLV | PTAFEKQGSS | KLEKAEVLQM | TVDHLKMLHA | 
    150:
    TGGTGFFDAR | ALAVDFRSIG | FRECLTEVIR | YLGVLEGPSS | RADPVRIRLL | 
    200:
    SHLNSYAAEM | EPSPTPTGPL | AFPAWPWSFF | HSCPGLPALS | NQLAILGRVP | 
    250:
    SPVLPGVSSP | AYPIPALRTA | PLRRATGIIL | PARRNVLPSR | GASSTRRARP | 
    300:
    LERPATPVPV | APSSRAARSS | HIAPLLQSSS | PTPPGPTGSA | AYVAVPTPNS | 
    328:
    SSPGPAGRPA | GAMLYHSWVS | EITEIGAF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    Pfam:
    String:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human hHeyL
    ELISA Kit for Human hHeyL
    ELISA Kit for Human hHeyL
    CLIA Kit for Human hHeyL
    CLIA Kit for Human hHeyL
    CLIA Kit for Human hHeyL
    Polyclonal Antibody for Human hHeyL
    Polyclonal Antibody for Human hHeyL
    Polyclonal Antibody for Human hHeyL
    Monoclonal Antibody for Human hHeyL
    Monoclonal Antibody for Human hHeyL
    Monoclonal Antibody for Human hHeyL
    Protein for Human hHeyL
    Protein for Human hHeyL
    Protein for Human hHeyL

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family."
      Steidl C. , Leimeister C. , Klamt B. , Maier M. , Nanda I. , Dixon M. , Clarke R. , Schmid M. , Gessler M.
      Genomics66:195-203(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-47
    2. 2.
      "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."
      Nakagawa O. , McFadden D.G. , Nakagawa M. , Yanagisawa H. , Hu T. , Srivastava D. , Olson E.N.
      Proc. Natl. Acad. Sci. U.S.A.97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-47
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Muscle.
    5. 5.
      "Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes."
      Maier M.M. , Gessler M.
      Biochem. Biophys. Res. Commun.275:652-660(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    6. 6.
      "Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."
      Kathiriya I.S. , King I.N. , Murakami M. , Nakagawa M. , Astle J.M. , Gardner K.A. , Gerard R.D. , Olson E.N. , Srivastava D. , Nakagawa O.
      J. Biol. Chem.279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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