Gene name:
HEYL (BHLHB33;HRT3) ;
Protein name:
Hairy/enhancer-of-split related with YRPW motif-like protein (hHeyL) ;
Alternative:
Hairy-related transcription factor 3 (HRT-3;hHRT3) ;Class B basic helix-loop-helix protein 33 (bHLHb33) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Self-associates (By similarity). Interacts with GATA4, GATA6, HES1, HEY1 and HEY2 (By similarity). Interacts with HDAC1, NCOR1 and SIN3A.
Function:
Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MKRPKEPSGS | DGESDGPIDV | GQEGQLSQMA | RPLSTPSSSQ | MQARKKHRGI |
100:
IEKRRRDRIN | SSLSELRRLV | PTAFEKQGSS | KLEKAEVLQM | TVDHLKMLHA |
150:
TGGTGFFDAR | ALAVDFRSIG | FRECLTEVIR | YLGVLEGPSS | RADPVRIRLL |
200:
SHLNSYAAEM | EPSPTPTGPL | AFPAWPWSFF | HSCPGLPALS | NQLAILGRVP |
250:
SPVLPGVSSP | AYPIPALRTA | PLRRATGIIL | PARRNVLPSR | GASSTRRARP |
300:
LERPATPVPV | APSSRAARSS | HIAPLLQSSS | PTPPGPTGSA | AYVAVPTPNS |
328:
SSPGPAGRPA | GAMLYHSWVS | EITEIGAF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
ELISA Kit for Human hHeyL
ELISA Kit for Human hHeyL
ELISA Kit for Human hHeyL
Polyclonal Antibody for Human hHeyL
Polyclonal Antibody for Human hHeyL
Polyclonal Antibody for Human hHeyL
Monoclonal Antibody for Human hHeyL
Monoclonal Antibody for Human hHeyL
Monoclonal Antibody for Human hHeyL
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family."
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-47
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-47
3.
"The DNA sequence and biological annotation of human chromosome 1."
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more...
Nature441:315-321(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Muscle .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION