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Index > Protein center > Heyl(Gene name) > Mouse
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  • Heyl (Gene name),
  • Hairy/enhancer-of-split related with YRPW motif-like protein (Protein name ),  HEYL_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Heyl(Hesr3;Hrt3);
    Protein name:
    Hairy/enhancer-of-split related with YRPW motif-like protein;
    Alternative:
    Hairy-related transcription factor 3(HRT-3;mHRT3);Hairy and enhancer of split-related protein 3;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with HES1, HDAC1, NCOR1 and SIN3A (By similarity). Self-associates. Interacts with GATA4, GATA6, HEY1 and HEY2.
    Function:
    Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    326
    Sequence:
    50:
    MKRPRAPSGS | DGESDGPIDV | GQENDLSQMA | RPLTTPSPSQ | MQARKKRRGI | 
    100:
    IEKRRRDRIN | SSLSELRRLV | PTAFEKQGSS | KLEKAEVLQM | TVDHLKMLHA | 
    150:
    SGGTGFFDAR | ALAVDFRSIG | FRECLTEVIR | YLGVLEGPSS | HADPVRIRLL | 
    200:
    SHLKSYAAEM | EPSPTTTSAL | AFPVWPWSFL | HSCPGLPSLN | SQLAILGRVP | 
    250:
    GPVLPSISSP | PYPISALRSA | PVHRPAGTIP | PTRRNLLPSR | GVTSTQRAHL | 
    300:
    PERPAAPPPT | ALDARAARSI | VPIPPCSPTT | APGAGKSDDN | VSGSISSPCP | 
    326:
    SGPTGRPAGA | VFYHSWVSEI | TEIGAF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    KEGG:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    ELISA Kit for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    ELISA Kit for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    CLIA Kit for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    CLIA Kit for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    CLIA Kit for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    Polyclonal Antibody for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    Polyclonal Antibody for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    Polyclonal Antibody for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    Monoclonal Antibody for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    Monoclonal Antibody for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    Monoclonal Antibody for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    Protein for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    Protein for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein
    Protein for Mouse Hairy/enhancer-of-split related with YRPW motif-like protein

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "HRT1, HRT2 and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic and pharyngeal arch segments."
      Nakagawa O. , Nakagawa M. , Richardson J.A. , Olson E.N. , Srivastava D.
      Dev. Biol.216:72-84(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family."
      Steidl C. , Leimeister C. , Klamt B. , Maier M. , Nanda I. , Dixon M. , Clarke R. , Schmid M. , Gessler M.
      Genomics66:195-203(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
    3. 3.
      "Cloning of hesr2 gene."
      Kokubo H. , Johnson R.L.
      Submitted (2002-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Corpora quadrigemina.
      tissue: Lung.
      tissue: Skin.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos."
      Leimeister C. , Schumacher N. , Steidl C. , Gessler M.
      Mech. Dev.98:175-178(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
    8. 8.
      "The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina."
      Satow T. , Bae S.-K. , Inoue T. , Inoue C. , Miyoshi G. , Tomita K. , Bessho Y. , Hashimoto N. , Kageyama R.
      J. Neurosci.21:1265-1273(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
    9. 9.
      "Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts."
      Fischer A. , Klattig J. , Kneitz B. , Diez H. , Maier M. , Holtmann B. , Englert C. , Gessler M.
      Mol. Cell. Biol.25:8960-8970(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GATA4 AND GATA6
    10. 10.
      "Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
      Fischer A. , Steidl C. , Wagner T.U. , Lang E. , Jakob P.M. , Friedl P. , Knobeloch K.-P. , Gessler M.
      Circ. Res.100:856-863(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SELF-ASSOCIATION;INTERACTION WITH HEY1 AND HEY2;DEVELOPMENTAL STAGE
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