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Index > Protein center > HYAL2(Gene name) > Human
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  • HYAL2 (Gene name),
  • Hyaluronidase-2 (Protein name ),  HYAL2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    HYAL2(LUCA2);
    Protein name:
    Hyaluronidase-2(Hyal-2);
    Alternative:
    Lung carcinoma protein 2(LuCa-2);Hyaluronoglucosaminidase-2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MST1R.
    Function:
    Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor
    Protein Attributes:
    Sequence length:
    473
    Sequence:
    50:
    MRAGPGPTVT | LALVLAVSWA | MELKPTAPPI | FTGRPFVVAW | DVPTQDCGPR | 
    100:
    LKVPLDLNAF | DVQASPNEGF | VNQNITIFYR | DRLGLYPRFD | SAGRSVHGGV | 
    150:
    PQNVSLWAHR | KMLQKRVEHY | IRTQESAGLA | VIDWEDWRPV | WVRNWQDKDV | 
    200:
    YRRLSRQLVA | SRHPDWPPDR | IVKQAQYEFE | FAAQQFMLET | LRYVKAVRPR | 
    250:
    HLWGFYLFPD | CYNHDYVQNW | ESYTGRCPDV | EVARNDQLAW | LWAESTALFP | 
    300:
    SVYLDETLAS | SRHGRNFVSF | RVQEALRVAR | THHANHALPV | YVFTRPTYSR | 
    350:
    RLTGLSEMDL | ISTIGESAAL | GAAGVILWGD | AGYTTSTETC | QYLKDYLTRL | 
    400:
    LVPYVVNVSW | ATQYCSRAQC | HGHGRCVRRN | PSASTFLHLS | TNSFRLVPGH | 
    450:
    APGEPQLRPV | GELSWADIDH | LQTHFRCQCY | LGWSGEQCQW | DHRQAAGGAS | 
    473:
    EAWAGSHLTS | LLALAALAFT | WTL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    KEGG:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Hyal-2
    Cat.:
    E1126h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Hyal-2
    Cat.:
    E1126r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Hyal-2
    Cat.:
    E1126b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Hyal-2
    Cat.:
    E1126m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hyal-2
    Cat.:
    U1126m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hyal-2
    Cat.:
    U1126b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hyal-2
    Cat.:
    U1126r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Hyal-2
    Cat.:
    U1126h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Hyal-2
    Cat.:
    P1126Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Hyal-2
    Cat.:
    P1126Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Hyal-2
    Polyclonal Antibody for Human Hyal-2
    Cat.:
    P1126Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Hyal-2
    Monoclonal Antibody for Human Hyal-2
    Monoclonal Antibody for Human Hyal-2
    Monoclonal Antibody for Human Hyal-2
    Protein for Human Hyal-2
    Protein for Human Hyal-2
    Protein for Human Hyal-2
    Protein for Human Hyal-2

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    References
    1. 1.
      "HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity."
      Lepperdinger G. , Strobl B. , Kreil G.
      J. Biol. Chem.273:22466-22470(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;VARIANT ALA-18
    2. 2.
      "LUCA2 (HYAL2, lysosomal hyaluronidase) a novel human cDNA with homology to human PH-20 gene is homozygously deleted in small cell lung cancer and located in 3p21.3."
      Chen J. , Bader S. , Latif F. , Duh F.-M. , Lerman M.I. , Minna J.D.
      Submitted (1998-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Placenta.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-18
      tissue: Placenta.
      tissue: Synovium.
    4. 4.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-18
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-18
      tissue: Kidney.
    7. 7.
      Yu W. , Gibbs R.A.
      Submitted (1998-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-473;VARIANT ALA-18
      tissue: Brain.
    8. 8.
      "Hyal2 -- less active, but more versatile?"
      Lepperdinger G. , Mullegger J. , Kreil G.
      Matrix Biol.20:509-514(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    9. 9.
      "Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation."
      Rai S.K. , Duh F.-M. , Vigdorovich V. , Danilkovitch-Miagkova A. , Lerman M.I. , Miller A.D.
      Proc. Natl. Acad. Sci. U.S.A.98:4443-4448(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    10. 10.
      "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus."
      Danilkovitch-Miagkova A. , Duh F.-M. , Kuzmin I. , Angeloni D. , Liu S.-L. , Miller A.D. , Lerman M.I.
      Proc. Natl. Acad. Sci. U.S.A.100:4580-4585(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MST1R
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