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Index > Protein center > IL1RAP(Gene name) > Human
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  • IL1RAP (Gene name),
  • Interleukin-1 receptor accessory protein (Protein name ),  IL1AP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    IL1RAP(C3orf13;IL1R3);
    Protein name:
    Interleukin-1 receptor accessory protein(IL-1 receptor accessory protein;IL-1RAcP);
    Alternative:
    Interleukin-1 receptor 3(IL-1R-3;IL-1R3);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    The signaling-competent complex is a heterodimer of IL1R2 and IL1RAP bound to IL1B.
    Function:
    Mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.
    Subcellular Location:
    Isoform 3 Secreted
    Protein Attributes:
    Sequence length:
    570
    Sequence:
    50:
    MTLLWCVVSL | YFYGILQSDA | SERCDDWGLD | TMRQIQVFED | EPARIKCPLF | 
    100:
    EHFLKFNYST | AHSAGLTLIW | YWTRQDRDLE | EPINFRLPEN | RISKEKDVLW | 
    150:
    FRPTLLNDTG | NYTCMLRNTT | YCSKVAFPLE | VVQKDSCFNS | PMKLPVHKLY | 
    200:
    IEYGIQRITC | PNVDGYFPSS | VKPTITWYMG | CYKIQNFNNV | IPEGMNLSFL | 
    250:
    IALISNNGNY | TCVVTYPENG | RTFHLTRTLT | VKVVGSPKNA | VPPVIHSPND | 
    300:
    HVVYEKEPGE | ELLIPCTVYF | SFLMDSRNEV | WWTIDGKKPD | DITIDVTINE | 
    350:
    SISHSRTEDE | TRTQILSIKK | VTSEDLKRSY | VCHARSAKGE | VAKAAKVKQK | 
    400:
    VPAPRYTVEL | ACGFGATVLL | VVILIVVYHV | YWLEMVLFYR | AHFGTDETIL | 
    450:
    DGKEYDIYVS | YARNAEEEEF | VLLTLRGVLE | NEFGYKLCIF | DRDSLPGGIV | 
    500:
    TDETLSFIQK | SRRLLVVLSP | NYVLQGTQAL | LELKAGLENM | ASRGNINVIL | 
    550:
    VQYKAVKETK | VKELKRAKTV | LTVIKWKGEK | SKYPQGRFWK | QLQVAMPVKK | 
    570:
    SPRRSSSDEQ | GLSYSSLKNV | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    String:
    SMR:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-1 receptor accessory protein
    ELISA Kit for Human IL-1 receptor accessory protein
    ELISA Kit for Human IL-1 receptor accessory protein
    CLIA Kit for Human IL-1 receptor accessory protein
    CLIA Kit for Human IL-1 receptor accessory protein
    CLIA Kit for Human IL-1 receptor accessory protein
    Polyclonal Antibody for Human IL-1 receptor accessory protein
    Polyclonal Antibody for Human IL-1 receptor accessory protein
    Polyclonal Antibody for Human IL-1 receptor accessory protein
    Monoclonal Antibody for Human IL-1 receptor accessory protein
    Monoclonal Antibody for Human IL-1 receptor accessory protein
    Monoclonal Antibody for Human IL-1 receptor accessory protein
    Protein for Human IL-1 receptor accessory protein
    Protein for Human IL-1 receptor accessory protein
    Protein for Human IL-1 receptor accessory protein

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    Precision
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    Linearity
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    References
    1. 1.
      "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein."
      Huang J. , Gao X. , Li S. , Cao Z.
      Proc. Natl. Acad. Sci. U.S.A.94:12829-12832(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH IL1R1 AND IRAK1
      tissue: Placenta.
    2. 2.
      Saito T. , Seki N.
      Submitted (1997-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      "IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein."
      Jensen L.E. , Muzio M. , Mantovani A. , Whitehead A.S.
      J. Immunol.164:5277-5286(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2);FUNCTION;INDUCTION BY PHORBOL ESTERS
      tissue: Liver.
    4. 4.
      "Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis."
      Jensen L.E. , Whitehead A.S.
      Cell. Signal.15:793-802(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);INDUCTION BY PHORBOL ESTERS
      tissue: Liver.
    5. 5.
      "A novel alternatively spliced interleukin-1 receptor accessory protein mIL-1RAcP687."
      Lu H.L. , Yang C.Y. , Chen H.C. , Hung C.S. , Chiang Y.C. , Ting L.P.
      Mol. Immunol.45:1374-1384(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
    6. 6.
      "A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1."
      Smith D.E. , Lipsky B.P. , Russell C. , Ketchem R.R. , Kirchner J. , Hensley K. , Huang Y. , Friedman W.J. , Boissonneault V. , Plante M.M. , Rivest S. , Sims J.E.
      Immunity30:817-831(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
    7. 7.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Skin.
    10. 10.
      "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping."
      Dale M. , Hammond D.W. , Cox A. , Nicklin M.J.H.
      Genomics47:325-326(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-179
    11. 11.
      "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness."
      Lang D. , Knop J. , Wesche H. , Raffetseder U. , Kurrle R. , Boraschi D. , Martin M.U.
      J. Immunol.161:6871-6877(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IL1R2
    12. 12.
      "Characterization of a cascade of protein interactions initiated at the IL-1 receptor."
      Boch J.A. , Yoshida Y. , Koyama Y. , Wara-Aswapati N. , Peng H. , Unlu S. , Auron P.E.
      Biochem. Biophys. Res. Commun.303:525-531(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRAK2
    13. 13.
      "The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action."
      Smith D.E. , Hanna R. , Friend D. , Moore H. , Chen H. , Farese A.M. , MacVittie T.J. , Virca G.D. , Sims J.E.
      Immunity18:87-96(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (SECRETED FORMS);TISSUE SPECIFICITY
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-557;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    17. 17.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      "Structural insights into the assembly and activation of IL-1beta with its receptors."
      Wang D. , Zhang S. , Li L. , Liu X. , Mei K. , Wang X.
      Nat. Immunol.11:905-911(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 21-350 IN COMPLEX WITH IL1R2 AND IL1B;SUBUNIT;DISULFIDE BONDS;GLYCOSYLATION AT ASN-107; ASN-111; ASN-118 AND ASN-209
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