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Index > Protein center > KPNA2(Gene name) > Human
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  • KPNA2 (Gene name),
  • Importin subunit alpha-1 (Protein name ),  IMA2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    KPNA2(RCH1;SRP1);
    Protein name:
    Importin subunit alpha-1;
    Alternative:
    RAG cohort protein 1;Karyopherin subunit alpha-2;SRP1-alpha;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a complex with importin subunit beta-1. Found in a complex with CSE1L/XPO2, Ran and KPNA2. Interacts with CSE1L/XPO2 and NBN. Interacts with ANP32E (By similarity). Interacts with HIV-1 Vpr and PLAG1. Interacts with APEX1 (via N-terminus). Interacts with ARL4A; the interaction is direct.
    Function:
    Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    529
    Sequence:
    50:
    MSTNENANTP | AARLHRFKNK | GKDSTEMRRR | RIEVNVELRK | AKKDDQMLKR | 
    100:
    RNVSSFPDDA | TSPLQENRNN | QGTVNWSVDD | IVKGINSSNV | ENQLQATQAA | 
    150:
    RKLLSREKQP | PIDNIIRAGL | IPKFVSFLGR | TDCSPIQFES | AWALTNIASG | 
    200:
    TSEQTKAVVD | GGAIPAFISL | LASPHAHISE | QAVWALGNIA | GDGSVFRDLV | 
    250:
    IKYGAVDPLL | ALLAVPDMSS | LACGYLRNLT | WTLSNLCRNK | NPAPPIDAVE | 
    300:
    QILPTLVRLL | HHDDPEVLAD | TCWAISYLTD | GPNERIGMVV | KTGVVPQLVK | 
    350:
    LLGASELPIV | TPALRAIGNI | VTGTDEQTQV | VIDAGALAVF | PSLLTNPKTN | 
    400:
    IQKEATWTMS | NITAGRQDQI | QQVVNHGLVP | FLVSVLSKAD | FKTQKEAVWA | 
    450:
    VTNYTSGGTV | EQIVYLVHCG | IIEPLMNLLT | AKDTKIILVI | LDAISNIFQA | 
    500:
    AEKLGETEKL | SIMIEECGGL | DKIEALQNHE | NESVYKASLS | LIEKYFSVEE | 
    529:
    EEDQNVVPET | TSEGYTFQVQ | DGAPGTFNF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    KEGG:
    MIM:
    UniGene:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Importin subunit alpha-1
    Cat.:
    E1138h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Importin subunit alpha-1
    Cat.:
    E1138m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Importin subunit alpha-1
    Cat.:
    U1138h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Importin subunit alpha-1
    Cat.:
    U1138m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Importin subunit alpha-1
    Cat.:
    P1138Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Importin subunit alpha-1
    Cat.:
    P1138Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Importin subunit alpha-1
    Monoclonal Antibody for Human Importin subunit alpha-1
    Protein for Human Importin subunit alpha-1
    Protein for Human Importin subunit alpha-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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