KPNA2 ELISA Kit for Human(Homo sapiens) | EIAab.comKPNA2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > KPNA2(Gene name) > Human

KPNA2 (Gene name),

Importin subunit alpha-1 (Protein name ), IMA2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KPNA2(RCH1;SRP1);

Protein name:

Importin subunit alpha-1;

Alternative:

RAG cohort protein 1;Karyopherin subunit alpha-2;SRP1-alpha;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms a complex with importin subunit beta-1. Found in a complex with CSE1L/XPO2, Ran and KPNA2. Interacts with CSE1L/XPO2 and NBN. Interacts with ANP32E (By similarity). Interacts with HIV-1 Vpr and PLAG1. Interacts with APEX1 (via N-terminus). Interacts with ARL4A; the interaction is direct.

Function:

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

529

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

529:

EEDQNVVPET | TSEGYTFQVQ | DGAPGTFNF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00514

KEGG:

hsa:3838

MIM:

600685

UniGene:

Hs.594238

String:

P52292

SMR:

P52292

Uniprot:

P52292

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ELISA Kit for Human Importin subunit alpha-1

Cat.:

E1138h

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Manual:

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Packing:

96T

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ELISA Kit for Human Importin subunit alpha-1

Cat.:

E1138m

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MSDS:

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Packing:

96T

CLIA Kit for Human Importin subunit alpha-1

Cat.:

U1138h

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Human Importin subunit alpha-1

Cat.:

U1138m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Importin subunit alpha-1

Cat.:

P1138Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Importin subunit alpha-1

Cat.:

P1138Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Importin subunit alpha-1

Protein for Human Importin subunit alpha-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

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