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Index > Protein center > ITGB3(Gene name) > Human
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  • ITGB3 (Gene name),
  • Integrin beta-3 (Protein name ),  ITB3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ITGB3(GP3A);
    Protein name:
    Integrin beta-3;
    Alternative:
    Platelet membrane glycoprotein IIIa(GPIIIa);
    CD:
    CD61;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with HIV-1 Tat. Interacts with PDIA6 following platelet stimulation.
    Function:
    Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    788
    Sequence:
    50:
    MRARPRPRPL | WATVLALGAL | AGVGVGGPNI | CTTRGVSSCQ | QCLAVSPMCA | 
    100:
    WCSDEALPLG | SPRCDLKENL | LKDNCAPESI | EFPVSEARVL | EDRPLSDKGS | 
    150:
    GDSSQVTQVS | PQRIALRLRP | DDSKNFSIQV | RQVEDYPVDI | YYLMDLSYSM | 
    200:
    KDDLWSIQNL | GTKLATQMRK | LTSNLRIGFG | AFVDKPVSPY | MYISPPEALE | 
    250:
    NPCYDMKTTC | LPMFGYKHVL | TLTDQVTRFN | EEVKKQSVSR | NRDAPEGGFD | 
    300:
    AIMQATVCDE | KIGWRNDASH | LLVFTTDAKT | HIALDGRLAG | IVQPNDGQCH | 
    350:
    VGSDNHYSAS | TTMDYPSLGL | MTEKLSQKNI | NLIFAVTENV | VNLYQNYSEL | 
    400:
    IPGTTVGVLS | MDSSNVLQLI | VDAYGKIRSK | VELEVRDLPE | ELSLSFNATC | 
    450:
    LNNEVIPGLK | SCMGLKIGDT | VSFSIEAKVR | GCPQEKEKSF | TIKPVGFKDS | 
    500:
    LIVQVTFDCD | CACQAQAEPN | SHRCNNGNGT | FECGVCRCGP | GWLGSQCECS | 
    550:
    EEDYRPSQQD | ECSPREGQPV | CSQRGECLCG | QCVCHSSDFG | KITGKYCECD | 
    600:
    DFSCVRYKGE | MCSGHGQCSC | GDCLCDSDWT | GYYCNCTTRT | DTCMSSNGLL | 
    650:
    CSGRGKCECG | SCVCIQPGSY | GDTCEKCPTC | PDACTFKKEC | VECKKFDRGA | 
    700:
    LHDENTCNRY | CRDEIESVKE | LKDTGKDAVN | CTYKNEDDCV | VRFQYYEDSS | 
    750:
    GKSILYVVEE | PECPKGPDIL | VVLLSVMGAI | LLIGLAALLI | WKLLITIHDR | 
    788:
    KEFAKFEEER | ARAKWDTANN | PLYKEATSTF | TNITYRGT
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    Pfam:
    MIM:
    UniGene:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Integrin beta-3
    Cat.:
    E15079h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Integrin beta-3
    Cat.:
    E15079m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Integrin beta-3
    Cat.:
    U15079h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Integrin beta-3
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Integrin beta-3
    Polyclonal Antibody for Human Integrin beta-3
    Monoclonal Antibody for Human Integrin beta-3
    Monoclonal Antibody for Human Integrin beta-3
    Protein for Human Integrin beta-3
    Protein for Human Integrin beta-3

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to 'integrin'."
      Fitzgerald L.A. , Steiner B. , Rall S.C. Jr. , Lo S. , Phillips D.R.
      J. Biol. Chem.262:3936-3939(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3A)
    2. 2.
      "Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors."
      Zimrin A.B. , Eisman R. , Vilaire G. , Schwartz E. , Bennett J.S. , Poncz M.
      J. Clin. Invest.81:1470-1475(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3A)
    3. 3.
      "GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs."
      Frachet P. , Uzan G. , Thevenon D. , Denarier E. , Prandini M.H. , Marguerie G.
      Mol. Biol. Rep.14:27-33(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3A)
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3C);FUNCTION;SUBCELLULAR LOCATION
      tissue: Osteoclastoma.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-3A)
    7. 7.
      "Isolation and characterization of a TATA-less promoter for the human beta 3 integrin gene."
      Villa-Garcia M. , Li L. , Riely G. , Bray P.F.
      Blood83:668-676(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26
      tissue: Blood.
    8. 8.
      "Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17."
      Rosa J.P. , Bray P.F. , Gayet O. , Johnston G.I. , Cook R.G. , Jackson K.W. , Shuman M.A. , McEver R.P.
      Blood72:593-600(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-788
      tissue: Erythroleukemia.
    9. 9.
      "Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing."
      Catimel B. , Parmentier S. , Leung L.L. , McGregor J.L.
      Biochem. J.279:419-425(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-37
      tissue: Platelet.
    10. 10.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-34
      tissue: Platelet.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-788
    12. 12.
      "Characterization of the human platelet glycoprotein IIIa gene. Comparison with the fibronectin receptor beta-subunit gene."
      Lanza F. , Kieffer N. , Phillips D.R. , Fitzgerald L.A.
      J. Biol. Chem.265:18098-18103(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-788
    13. 13.
      "A new exon II polymorphism in the platelet glycoprotein IIIa."
      Pascual C. , Balas A. , Garcia-Sanchez F. , Rodriguez de la Rua A. , Vicario J.L.
      Submitted (1993-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 56-120;VARIANTS PRO-59 AND ARG-66
      tissue: Blood.
    14. 14.
      "The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1."
      Jiang W.-M. , Jenkins D. , Yuan Q. , Leung E. , Choo K.H. , Watson J.D. , Krissansen G.W.
      Int. Immunol.4:1031-1040(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 122-204
    15. 15.
      "Purification and partial amino acid sequence of human platelet membrane glycoproteins IIb and IIIa."
      Hiraiwa A. , Matsukage A. , Shiku H. , Takahashi T. , Naito K. , Yamada K.
      Blood69:560-564(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 218-234 AND 439-443
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 707-788 (ISOFORM BETA-3B)
      tissue: Placenta.
    17. 17.
      "Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family."
      Calvete J.J. , Henschen A. , Gonzalez-Rodriguez J.
      Biochem. J.274:63-71(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;DISULFIDE BONDS
    18. 18.
      "Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation."
      Law D.A. , Nannizzi-Alaimo L. , Phillips D.R.
      J. Biol. Chem.271:10811-10815(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-773 AND TYR-785 (ISOFORM BETA-3A)
    19. 19.
      "The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor."
      Barillari G. , Sgadari C. , Fiorelli V. , Samaniego F. , Colombini S. , Manzari V. , Modesti A. , Nair B.C. , Cafaro A. , Stuerzl M. , Ensoli B.
      Blood94:663-672(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 TAT;FUNCTION
    20. 20.
      "Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding."
      Kirk R.I. , Sanderson M.R. , Lerea K.M.
      J. Biol. Chem.275:30901-30906(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-779
    21. 21.
      "Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton."
      Obergfell A. , Eto K. , Mocsai A. , Buensuceso C. , Moores S.L. , Brugge J.S. , Lowell C.A. , Shattil S.J.
      J. Cell Biol.157:265-275(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYK
    22. 22.
      "Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits."
      van Der Flier A. , Kuikman I. , Kramer D. , Geerts D. , Kreft M. , Takafuta T. , Shapiro S.S. , Sonnenberg A.
      J. Cell Biol.156:361-376(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLNB
      tissue: Keratinocyte.
      tissue: Skeletal muscle.
    23. 23.
      "Myosin-X provides a motor-based link between integrins and the cytoskeleton."
      Zhang H. , Berg J.S. , Li Z. , Wang Y. , Lang P. , Sousa A.D. , Bhaskar A. , Cheney R.E. , Stromblad S.
      Nat. Cell Biol.6:523-531(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYO10
    24. 24.
      "A role for the thiol isomerase protein ERP5 in platelet function."
      Jordan P.A. , Stevens J.M. , Hubbard G.P. , Barrett N.E. , Sage T. , Authi K.S. , Gibbins J.M.
      Blood105:1500-1507(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDIA6
    25. 25.
      "Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins."
      Chen F.-H. , Thomas A.O. , Hecht J.T. , Goldring M.B. , Lawler J.
      J. Biol. Chem.280:32655-32661(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COMP
    26. 26.
      "Structure and function of the platelet integrin alphaIIbbeta3."
      Bennett J.S.
      J. Clin. Invest.115:3363-3369(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    27. 27.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-125
      tissue: Plasma.
    28. 28.
      "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
      Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-125
      tissue: Platelet.
    29. 29.
      "Platelet integrin alpha(IIb)beta(3): activation mechanisms."
      Ma Y.Q. , Qin J. , Plow E.F.
      J. Thromb. Haemost.5:1345-1352(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    30. 30.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-773;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    31. 31.
      "Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor."
      Garrigues H.J. , Rubinchikova Y.E. , Dipersio C.M. , Rose T.M.
      J. Virol.82:1570-1580(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-8 GLYCOPROTEIN B;FUNCTION
    32. 32.
      "Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101-positive antigen-presenting cells."
      Anani Sarab G. , Moss M. , Barker R.N. , Urbaniak S.J.
      Blood114:1954-1957(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF ALLOANTIGEN HPA-1A BY MASS SPECTROMETRY;ASSOCIATION TO ALLELE HLA-DRB3*01:01
    33. 33.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-680
      tissue: Liver.
    34. 34.
      "Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation."
      Bledzka K. , Bialkowska K. , Nie H. , Qin J. , Byzova T. , Wu C. , Plow E.F. , Ma Y.Q.
      J. Biol. Chem.285:30370-30374(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FERMT2;SUBCELLULAR LOCATION
    35. 35.
      "Crystal structure of the extracellular segment of integrin alpha Vbeta3."
      Xiong J.P. , Stehle T. , Diefenbach B. , Zhang R. , Dunker R. , Scott D.L. , Joachimiak A. , Goodman S.L. , Arnaout M.A.
      Science294:339-345(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 27-718;GLYCOSYLATION AT ASN-346; ASN-397; ASN-585 AND ASN-680
    36. 36.
      "Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity."
      Parry C.S. , Gorski J. , Stern L.J.
      J. Mol. Biol.371:435-446(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 50-61 (ALLOANTIGEN HPA-1A) IN COMPLEX WITH HLA-DRA/HLA-DRB3 HETERODIMER
    37. 37.
      "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization."
      Bray P.F.
      Thromb. Haemost.72:492-502(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON GT VARIANTS
    38. 38.
      "The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing."
      Newman P.J. , Derbes R.S. , Aster R.H.
      J. Clin. Invest.83:1778-1781(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HPA-1B PRO-59;DESCRIPTION OF ALLOANTIGEN SYSTEM PL(A)
    39. 39.
      "An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system."
      Wang R. , Furihata K. , McFarland J.G. , Friedman K. , Aster R.H. , Newman P.J.
      J. Clin. Invest.90:2038-2043(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HPA-4B GLN-169;DESCRIPTION OF ALLOANTIGEN SYSTEM PEN
    40. 40.
      "Single point mutation in human glycoprotein IIIa is associated with a new platelet-specific alloantigen (Mo) involved in neonatal alloimmune thrombocytopenia."
      Kuijpers R.W.A.M. , Simsek S. , Faber N.M. , Goldschmeding R. , van Wermerkerken R.K.V. , von Dem Borne A.E.G.K.
      Blood81:70-76(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MO(+) ALA-433
    41. 41.
      "Amino acid 489 is encoded by a mutational 'hot spot' on the beta 3 integrin chain: the CA/TU human platelet alloantigen system."
      Wang R. , McFarland J.G. , Kekomaki R. , Newman P.J.
      Blood82:3386-3391(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CA(+)/TU(+) GLN-515;DESCRIPTION OF ALLOANTIGEN SYSTEM CA/TU
    42. 42.
      "A point mutation leads to an unpaired cysteine residue and a molecular weight polymorphism of a functional platelet beta 3 integrin subunit. The Sra alloantigen system of GPIIIa."
      Santoso S. , Kalb R. , Kroll H. , Walka M. , Kiefel V. , Mueller-Eckhardt C. , Newman P.J.
      J. Biol. Chem.269:8439-8444(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SR(A) CYS-662;DESCRIPTION OF ALLOANTIGEN SYSTEM SR(A)
    43. 43.
      "A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation."
      Loftus J.C. , O'Toole T.E. , Plow E.F. , Glass A. , Frelinger A.L. III , Ginsberg M.H.
      Science249:915-918(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT TYR-145
    44. 44.
      "A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site."
      Bajt M.L. , Ginsberg M.H. , Frelinger A.L. III , Berndt M.C. , Loftus J.C.
      J. Biol. Chem.267:3789-3794(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT GLN-240
    45. 45.
      "A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg-->214Trp mutation."
      Lanza F. , Stierle A. , Fournier D. , Morales M. , Andre G. , Nurden A.T. , Cazenave J.-P.
      J. Clin. Invest.89:1995-2004(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT TRP-240
    46. 46.
      "Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia."
      Chen Y.-P. , Djaffar I. , Pidard D. , Steiner B. , Cieutat A.-M. , Caen J.P. , Rosa J.-P.
      Proc. Natl. Acad. Sci. U.S.A.89:10169-10173(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT PRO-778
    47. 47.
      "A Cys374Tyr homozygous mutation of platelet glycoprotein IIIa (beta 3) in a Chinese patient with Glanzmann's thrombasthenia."
      Grimaldi C.M. , Chen F. , Scudder L.E. , Coller B.S. , French D.L.
      Blood88:1666-1675(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT TYR-400
    48. 48.
      "A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface."
      Basani R.B. , Brown D.L. , Vilaire G. , Bennett J.S. , Poncz M.
      Blood90:3082-3088(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT TRP-143
    49. 49.
      "Hematologically important mutations: Glanzmann thrombasthenia."
      French D.L. , Coller B.S.
      Blood Cells Mol. Dis.23:39-51(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GT ASN-145; GLN-242 AND PRO-288
    50. 50.
      "Three novel integrin beta3 subunit missense mutations (H280P, C560F, and G579S) in thrombasthenia, including one (H280P) prevalent in Japanese patients."
      Ambo H. , Kamata T. , Handa M. , Taki M. , Kuwajima M. , Kawai Y. , Oda A. , Murata M. , Takada Y. , Watanabe K. , Ikeda Y.
      Biochem. Biophys. Res. Commun.251:763-768(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GT PRO-306; PHE-586; SER-598 AND SER-605
    51. 51.
      "A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia."
      Jackson D.E. , White M.M. , Jennings L.K. , Newman P.J.
      Thromb. Haemost.80:42-48(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT LEU-188
    52. 52.
      "Homozygous Cys542-->Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann's thrombasthenia."
      Ruan J. , Schmugge M. , Clemetson K.J. , Cazes E. , Combrie R. , Bourre F. , Nurden A.T.
      Br. J. Haematol.105:523-531(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT ARG-568
    53. 53.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-59; GLN-169 AND ILE-453
    54. 54.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    55. 55.
      "A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype."
      Ruiz C. , Liu C.-Y. , Sun Q.-H. , Sigaud-Fiks M. , Fressinaud E. , Muller J.-Y. , Nurden P. , Nurden A.T. , Newman P.J. , Valentin N.
      Blood98:2432-2441(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT ARG-586;CHARACTERIZATION OF VARIANT GT ARG-586
    56. 56.
      "A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia."
      Jallu V. , Meunier M. , Brement M. , Kaplan C.
      Blood99:4449-4456(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-166;CHARACTERIZATION OF VARIANT ILE-166
    57. 57.
      "A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia."
      Nurden A.T. , Ruan J. , Pasquet J.-M. , Gauthier B. , Combrie R. , Kunicki T. , Nurden P.
      Platelets13:101-111(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT PRO-222
    58. 58.
      "Glanzmann's thrombasthenia: identification of 19 new mutations in 30 patients."
      D'Andrea G. , Colaizzo D. , Vecchione G. , Grandone E. , Di Minno G. , Margaglione M.
      Thromb. Haemost.87:1034-1042(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GT TRP-119; VAL-243 AND ARG-601
    59. 59.
      "Two new beta3 integrin mutations in Indian patients with Glanzmann thrombasthenia: localization of mutations affecting cysteine residues in integrin beta3."
      Nair S. , Li J. , Mitchell W.B. , Mohanty D. , Coller B.S. , French D.L.
      Thromb. Haemost.88:503-509(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT TYR-532
    60. 60.
      "A variant thrombasthenic phenotype associated with compound heterozygosity of integrin beta3-subunit: (Met124Val)beta3 alters the subunit dimerization rendering a decreased number of constitutive active alphaIIbbeta3 receptors."
      Gonzalez-Manchon C. , Butta N. , Larrucea S. , Arias-Salgado E.G. , Alonso S. , Lopez A. , Parrilla R.
      Thromb. Haemost.92:1377-1386(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT VAL-150;CHARACTERIZATION OF VARIANT GT VAL-150
    61. 61.
      "Double heterozygosity for a novel missense mutation of Ile304 to Asn in addition to the missense mutation His280 to Pro in the integrin beta3 gene as a cause of the absence of platelet alphaIIbbeta3 in Glanzmann's thrombasthenia."
      Tanaka S. , Hayashi T. , Yoshimura K. , Nakayama M. , Fujita T. , Amano T. , Tani Y.
      J. Thromb. Haemost.3:68-73(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GT PRO-306 AND ASN-330;CHARACTERIZATION OF VARIANT GT ASN-330
    62. 62.
      "Mutations in GPIIIa molecule as a cause for Glanzmann thrombasthenia in Indian patients."
      Nair S. , Ghosh K. , Shetty S. , Mohanty D.
      J. Thromb. Haemost.3:482-488(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GT CYS-141 AND LEU-321
    63. 63.
      "A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia."
      Ghevaert C. , Salsmann A. , Watkins N.A. , Schaffner-Reckinger E. , Rankin A. , Garner S.F. , Stephens J. , Smith G.A. , Debili N. , Vainchenker W. , de Groot P.G. , Huntington J.A. , Laffan M. , Kieffer N. , Ouwehand W.H.
      Blood111:3407-3414(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BDPLT16 HIS-749;CHARACTERIZATION OF VARIANT BDPLT16 HIS-749
    64. 64.
      "AlphaIIbbeta3 integrin: new allelic variants in Glanzmann thrombasthenia, effects on ITGA2B and ITGB3 mRNA splicing, expression, and structure-function."
      Jallu V. , Dusseaux M. , Panzer S. , Torchet M.F. , Hezard N. , Goudemand J. , de Brevern A.G. , Kaplan C.
      Hum. Mutat.31:237-246(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GT TYR-64; ARG-144; PRO-222; ASP-247 AND MET-279;CHARACTERIZATION OF VARIANTS TYR-64; PRO-222; ASP-247 AND MET-279;SUBCELLULAR LOCATION
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