ITGB3 ELISA Kit for Human(Homo sapiens) | EIAab.comITGB3 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > ITGB3(Gene name) > Human

ITGB3 (Gene name),

Integrin beta-3 (Protein name ), ITB3_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

ITGB3(GP3A);

Protein name:

Integrin beta-3;

Alternative:

Platelet membrane glycoprotein IIIa(GPIIIa);

CD:

CD61;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with HIV-1 Tat. Interacts with PDIA6 following platelet stimulation.

Function:

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

788

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

788:

KEFAKFEEER | ARAKWDTANN | PLYKEATSTF | TNITYRGT

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

P05106

Pfam:

PF07974

KEGG:

hsa:3690

Pfam:

PF08725

UniGene:

Hs.218040

SMR:

P05106

MIM:

173470

STRING:

9606.ENSP00000262017

Uniprot:

P05106

FOR

ELISA Kit for Human Integrin beta-3

Cat.:

E15079h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Integrin beta-3

Cat.:

E15079m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Integrin beta-3

Cat.:

U15079h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Integrin beta-3

MSDS:

Please sign in first.

Polyclonal Antibody for Human Integrin beta-3

Monoclonal Antibody for Human Integrin beta-3

Protein for Human Integrin beta-3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to 'integrin'."
Fitzgerald L.A. , Steiner B. , Rall S.C. Jr. , Lo S. , Phillips D.R.
J. Biol. Chem.262:3936-3939(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3A)
2.

"Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors."
Zimrin A.B. , Eisman R. , Vilaire G. , Schwartz E. , Bennett J.S. , Poncz M.
J. Clin. Invest.81:1470-1475(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3A)
3.

"GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs."
Frachet P. , Uzan G. , Thevenon D. , Denarier E. , Prandini M.H. , Marguerie G.
Mol. Biol. Rep.14:27-33(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3A)
4.

"Cloning and characterization of a novel integrin beta3 subunit."
Kumar C.S. , James I.E. , Wong A. , Mwangi V. , Feild J.A. , Nuthulaganti P. , Connor J.R. , Eichman C. , Ali F. , Hwang S.M. , Rieman D.J. , Drake F.H. , Gowen M.
J. Biol. Chem.272:16390-16397(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3C);FUNCTION;SUBCELLULAR LOCATION
tissue: Osteoclastoma.
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-3A)
7.

"Isolation and characterization of a TATA-less promoter for the human beta 3 integrin gene."
Villa-Garcia M. , Li L. , Riely G. , Bray P.F.
Blood83:668-676(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26
tissue: Blood.
8.

"Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17."
Rosa J.P. , Bray P.F. , Gayet O. , Johnston G.I. , Cook R.G. , Jackson K.W. , Shuman M.A. , McEver R.P.
Blood72:593-600(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-788
tissue: Erythroleukemia.
9.

"Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing."
Catimel B. , Parmentier S. , Leung L.L. , McGregor J.L.
Biochem. J.279:419-425(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-37
tissue: Platelet.
10.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-34
tissue: Platelet.
11.

"The genomic organization of platelet glycoprotein IIIa."
Zimrin A.B. , Gidwitz S. , Lord S. , Schwartz E. , Bennett J.S. , White G.C. II , Poncz M.
J. Biol. Chem.265:8590-8595(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-788
12.

"Characterization of the human platelet glycoprotein IIIa gene. Comparison with the fibronectin receptor beta-subunit gene."
Lanza F. , Kieffer N. , Phillips D.R. , Fitzgerald L.A.
J. Biol. Chem.265:18098-18103(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-788
13.

"A new exon II polymorphism in the platelet glycoprotein IIIa."
Pascual C. , Balas A. , Garcia-Sanchez F. , Rodriguez de la Rua A. , Vicario J.L.
Submitted (1993-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 56-120;VARIANTS PRO-59 AND ARG-66
tissue: Blood.
14.

"The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1."
Jiang W.-M. , Jenkins D. , Yuan Q. , Leung E. , Choo K.H. , Watson J.D. , Krissansen G.W.
Int. Immunol.4:1031-1040(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 122-204
15.

"Purification and partial amino acid sequence of human platelet membrane glycoproteins IIb and IIIa."
Hiraiwa A. , Matsukage A. , Shiku H. , Takahashi T. , Naito K. , Yamada K.
Blood69:560-564(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 218-234 AND 439-443
16.

"An alternative cytoplasmic domain of the integrin beta 3 subunit."
Van Kuppevelt T.H.M.S.M. , Languino L.R. , Gailit J.O. , Suzuki S. , Ruoslahti E.
Proc. Natl. Acad. Sci. U.S.A.86:5415-5418(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 707-788 (ISOFORM BETA-3B)
tissue: Placenta.
17.

"Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family."
Calvete J.J. , Henschen A. , Gonzalez-Rodriguez J.
Biochem. J.274:63-71(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;DISULFIDE BONDS
18.

"Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation."
Law D.A. , Nannizzi-Alaimo L. , Phillips D.R.
J. Biol. Chem.271:10811-10815(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-773 AND TYR-785 (ISOFORM BETA-3A)
19.

"The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor."
Barillari G. , Sgadari C. , Fiorelli V. , Samaniego F. , Colombini S. , Manzari V. , Modesti A. , Nair B.C. , Cafaro A. , Stuerzl M. , Ensoli B.
Blood94:663-672(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 TAT;FUNCTION
20.

"Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding."
Kirk R.I. , Sanderson M.R. , Lerea K.M.
J. Biol. Chem.275:30901-30906(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-779
21.

"Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton."
Obergfell A. , Eto K. , Mocsai A. , Buensuceso C. , Moores S.L. , Brugge J.S. , Lowell C.A. , Shattil S.J.
J. Cell Biol.157:265-275(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYK
22.

"Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits."
van Der Flier A. , Kuikman I. , Kramer D. , Geerts D. , Kreft M. , Takafuta T. , Shapiro S.S. , Sonnenberg A.
J. Cell Biol.156:361-376(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLNB
tissue: Keratinocyte.
tissue: Skeletal muscle.
23.

"Myosin-X provides a motor-based link between integrins and the cytoskeleton."
Zhang H. , Berg J.S. , Li Z. , Wang Y. , Lang P. , Sousa A.D. , Bhaskar A. , Cheney R.E. , Stromblad S.
Nat. Cell Biol.6:523-531(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYO10
24.

"A role for the thiol isomerase protein ERP5 in platelet function."
Jordan P.A. , Stevens J.M. , Hubbard G.P. , Barrett N.E. , Sage T. , Authi K.S. , Gibbins J.M.
Blood105:1500-1507(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDIA6
25.

"Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins."
Chen F.-H. , Thomas A.O. , Hecht J.T. , Goldring M.B. , Lawler J.
J. Biol. Chem.280:32655-32661(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COMP
26.

"Structure and function of the platelet integrin alphaIIbbeta3."
Bennett J.S.
J. Clin. Invest.115:3363-3369(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
27.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-125
tissue: Plasma.
28.

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-125
tissue: Platelet.
29.

"Platelet integrin alpha(IIb)beta(3): activation mechanisms."
Ma Y.Q. , Qin J. , Plow E.F.
J. Thromb. Haemost.5:1345-1352(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
30.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-773;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
31.

"Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor."
Garrigues H.J. , Rubinchikova Y.E. , Dipersio C.M. , Rose T.M.
J. Virol.82:1570-1580(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-8 GLYCOPROTEIN B;FUNCTION
32.

"Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101-positive antigen-presenting cells."
Anani Sarab G. , Moss M. , Barker R.N. , Urbaniak S.J.
Blood114:1954-1957(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF ALLOANTIGEN HPA-1A BY MASS SPECTROMETRY;ASSOCIATION TO ALLELE HLA-DRB3*01:01
33.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-680
tissue: Liver.
34.

"Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation."
Bledzka K. , Bialkowska K. , Nie H. , Qin J. , Byzova T. , Wu C. , Plow E.F. , Ma Y.Q.
J. Biol. Chem.285:30370-30374(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FERMT2;SUBCELLULAR LOCATION
35.

"Crystal structure of the extracellular segment of integrin alpha Vbeta3."
Xiong J.P. , Stehle T. , Diefenbach B. , Zhang R. , Dunker R. , Scott D.L. , Joachimiak A. , Goodman S.L. , Arnaout M.A.
Science294:339-345(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 27-718;GLYCOSYLATION AT ASN-346; ASN-397; ASN-585 AND ASN-680
36.

"Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity."
Parry C.S. , Gorski J. , Stern L.J.
J. Mol. Biol.371:435-446(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 50-61 (ALLOANTIGEN HPA-1A) IN COMPLEX WITH HLA-DRA/HLA-DRB3 HETERODIMER
37.

"Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization."
Bray P.F.
Thromb. Haemost.72:492-502(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON GT VARIANTS
38.

"The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing."
Newman P.J. , Derbes R.S. , Aster R.H.
J. Clin. Invest.83:1778-1781(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HPA-1B PRO-59;DESCRIPTION OF ALLOANTIGEN SYSTEM PL(A)
39.

"An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system."
Wang R. , Furihata K. , McFarland J.G. , Friedman K. , Aster R.H. , Newman P.J.
J. Clin. Invest.90:2038-2043(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HPA-4B GLN-169;DESCRIPTION OF ALLOANTIGEN SYSTEM PEN
40.

"Single point mutation in human glycoprotein IIIa is associated with a new platelet-specific alloantigen (Mo) involved in neonatal alloimmune thrombocytopenia."
Kuijpers R.W.A.M. , Simsek S. , Faber N.M. , Goldschmeding R. , van Wermerkerken R.K.V. , von Dem Borne A.E.G.K.
Blood81:70-76(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MO(+) ALA-433
41.

"Amino acid 489 is encoded by a mutational 'hot spot' on the beta 3 integrin chain: the CA/TU human platelet alloantigen system."
Wang R. , McFarland J.G. , Kekomaki R. , Newman P.J.
Blood82:3386-3391(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CA(+)/TU(+) GLN-515;DESCRIPTION OF ALLOANTIGEN SYSTEM CA/TU
42.

"A point mutation leads to an unpaired cysteine residue and a molecular weight polymorphism of a functional platelet beta 3 integrin subunit. The Sra alloantigen system of GPIIIa."
Santoso S. , Kalb R. , Kroll H. , Walka M. , Kiefel V. , Mueller-Eckhardt C. , Newman P.J.
J. Biol. Chem.269:8439-8444(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SR(A) CYS-662;DESCRIPTION OF ALLOANTIGEN SYSTEM SR(A)
43.

"A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation."
Loftus J.C. , O'Toole T.E. , Plow E.F. , Glass A. , Frelinger A.L. III , Ginsberg M.H.
Science249:915-918(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT TYR-145
44.

"A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site."
Bajt M.L. , Ginsberg M.H. , Frelinger A.L. III , Berndt M.C. , Loftus J.C.
J. Biol. Chem.267:3789-3794(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT GLN-240
45.

"A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg-->214Trp mutation."
Lanza F. , Stierle A. , Fournier D. , Morales M. , Andre G. , Nurden A.T. , Cazenave J.-P.
J. Clin. Invest.89:1995-2004(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT TRP-240
46.

"Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia."
Chen Y.-P. , Djaffar I. , Pidard D. , Steiner B. , Cieutat A.-M. , Caen J.P. , Rosa J.-P.
Proc. Natl. Acad. Sci. U.S.A.89:10169-10173(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT PRO-778
47.

"A Cys374Tyr homozygous mutation of platelet glycoprotein IIIa (beta 3) in a Chinese patient with Glanzmann's thrombasthenia."
Grimaldi C.M. , Chen F. , Scudder L.E. , Coller B.S. , French D.L.
Blood88:1666-1675(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT TYR-400
48.

"A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface."
Basani R.B. , Brown D.L. , Vilaire G. , Bennett J.S. , Poncz M.
Blood90:3082-3088(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT TRP-143
49.

"Hematologically important mutations: Glanzmann thrombasthenia."
French D.L. , Coller B.S.
Blood Cells Mol. Dis.23:39-51(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GT ASN-145; GLN-242 AND PRO-288
50.

"Three novel integrin beta3 subunit missense mutations (H280P, C560F, and G579S) in thrombasthenia, including one (H280P) prevalent in Japanese patients."
Ambo H. , Kamata T. , Handa M. , Taki M. , Kuwajima M. , Kawai Y. , Oda A. , Murata M. , Takada Y. , Watanabe K. , Ikeda Y.
Biochem. Biophys. Res. Commun.251:763-768(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GT PRO-306; PHE-586; SER-598 AND SER-605
51.

"A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia."
Jackson D.E. , White M.M. , Jennings L.K. , Newman P.J.
Thromb. Haemost.80:42-48(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT LEU-188
52.

"Homozygous Cys542-->Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann's thrombasthenia."
Ruan J. , Schmugge M. , Clemetson K.J. , Cazes E. , Combrie R. , Bourre F. , Nurden A.T.
Br. J. Haematol.105:523-531(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT ARG-568
53.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-59; GLN-169 AND ILE-453
54.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
55.

"A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype."
Ruiz C. , Liu C.-Y. , Sun Q.-H. , Sigaud-Fiks M. , Fressinaud E. , Muller J.-Y. , Nurden P. , Nurden A.T. , Newman P.J. , Valentin N.
Blood98:2432-2441(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT ARG-586;CHARACTERIZATION OF VARIANT GT ARG-586
56.

"A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia."
Jallu V. , Meunier M. , Brement M. , Kaplan C.
Blood99:4449-4456(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-166;CHARACTERIZATION OF VARIANT ILE-166
57.

"A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia."
Nurden A.T. , Ruan J. , Pasquet J.-M. , Gauthier B. , Combrie R. , Kunicki T. , Nurden P.
Platelets13:101-111(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT PRO-222
58.

"Glanzmann's thrombasthenia: identification of 19 new mutations in 30 patients."
D'Andrea G. , Colaizzo D. , Vecchione G. , Grandone E. , Di Minno G. , Margaglione M.
Thromb. Haemost.87:1034-1042(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GT TRP-119; VAL-243 AND ARG-601
59.

"Two new beta3 integrin mutations in Indian patients with Glanzmann thrombasthenia: localization of mutations affecting cysteine residues in integrin beta3."
Nair S. , Li J. , Mitchell W.B. , Mohanty D. , Coller B.S. , French D.L.
Thromb. Haemost.88:503-509(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT TYR-532
60.

"A variant thrombasthenic phenotype associated with compound heterozygosity of integrin beta3-subunit: (Met124Val)beta3 alters the subunit dimerization rendering a decreased number of constitutive active alphaIIbbeta3 receptors."
Gonzalez-Manchon C. , Butta N. , Larrucea S. , Arias-Salgado E.G. , Alonso S. , Lopez A. , Parrilla R.
Thromb. Haemost.92:1377-1386(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GT VAL-150;CHARACTERIZATION OF VARIANT GT VAL-150
61.

"Double heterozygosity for a novel missense mutation of Ile304 to Asn in addition to the missense mutation His280 to Pro in the integrin beta3 gene as a cause of the absence of platelet alphaIIbbeta3 in Glanzmann's thrombasthenia."
Tanaka S. , Hayashi T. , Yoshimura K. , Nakayama M. , Fujita T. , Amano T. , Tani Y.
J. Thromb. Haemost.3:68-73(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GT PRO-306 AND ASN-330;CHARACTERIZATION OF VARIANT GT ASN-330
62.

"Mutations in GPIIIa molecule as a cause for Glanzmann thrombasthenia in Indian patients."
Nair S. , Ghosh K. , Shetty S. , Mohanty D.
J. Thromb. Haemost.3:482-488(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GT CYS-141 AND LEU-321
63.

"A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia."
Ghevaert C. , Salsmann A. , Watkins N.A. , Schaffner-Reckinger E. , Rankin A. , Garner S.F. , Stephens J. , Smith G.A. , Debili N. , Vainchenker W. , de Groot P.G. , Huntington J.A. , Laffan M. , Kieffer N. , Ouwehand W.H.
Blood111:3407-3414(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BDPLT16 HIS-749;CHARACTERIZATION OF VARIANT BDPLT16 HIS-749
64.

"AlphaIIbbeta3 integrin: new allelic variants in Glanzmann thrombasthenia, effects on ITGA2B and ITGB3 mRNA splicing, expression, and structure-function."
Jallu V. , Dusseaux M. , Panzer S. , Torchet M.F. , Hezard N. , Goudemand J. , de Brevern A.G. , Kaplan C.
Hum. Mutat.31:237-246(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GT TYR-64; ARG-144; PRO-222; ASP-247 AND MET-279;CHARACTERIZATION OF VARIANTS TYR-64; PRO-222; ASP-247 AND MET-279;SUBCELLULAR LOCATION

Product Feedback Wall

* Email:
*Comments: