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Index > Protein center > KRT16(Gene name) > Human
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  • KRT16 (Gene name),
  • Keratin, type I cytoskeletal 16 (Protein name ),  K1C16_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    KRT16(KRT16A);
    Protein name:
    Keratin, type I cytoskeletal 16;
    Alternative:
    Keratin-16(K16);Cytokeratin-16(CK-16);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers. Interacts with TCHP. Interacts with TRADD.
    Function:
    N/A
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    473
    Sequence:
    50:
    MTTCSRQFTS | SSSMKGSCGI | GGGIGGGSSR | ISSVLAGGSC | RAPSTYGGGL | 
    100:
    SVSSRFSSGG | ACGLGGGYGG | GFSSSSSFGS | GFGGGYGGGL | GAGFGGGLGA | 
    150:
    GFGGGFAGGD | GLLVGSEKVT | MQNLNDRLAS | YLDKVRALEE | ANADLEVKIR | 
    200:
    DWYQRQRPSE | IKDYSPYFKT | IEDLRNKIIA | ATIENAQPIL | QIDNARLAAD | 
    250:
    DFRTKYEHEL | ALRQTVEADV | NGLRRVLDEL | TLARTDLEMQ | IEGLKEELAY | 
    300:
    LRKNHEEEML | ALRGQTGGDV | NVEMDAAPGV | DLSRILNEMR | DQYEQMAEKN | 
    350:
    RRDAETWFLS | KTEELNKEVA | SNSELVQSSR | SEVTELRRVL | QGLEIELQSQ | 
    400:
    LSMKASLENS | LEETKGRYCM | QLSQIQGLIG | SVEEQLAQLR | CEMEQQSQEY | 
    450:
    QILLDVKTRL | EQEIATYRRL | LEGEDAHLSS | QQASGQSYSS | REVFTSSSSS | 
    473:
    SSRQTRPILK | EQSSSSFSQG | QSS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    Pfam:
    MIM:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Keratin, type I cytoskeletal 16
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    E2305h
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    ELISA Kit for Human Keratin, type I cytoskeletal 16
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    Packing:
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    CLIA Kit for Human Keratin, type I cytoskeletal 16
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    U2305h
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    CLIA Kit for Human Keratin, type I cytoskeletal 16
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    Packing:
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    Polyclonal Antibody for Human Keratin, type I cytoskeletal 16
    Cat.:
    P2305Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Keratin, type I cytoskeletal 16
    Cat.:
    P2305Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Keratin, type I cytoskeletal 16
    Monoclonal Antibody for Human Keratin, type I cytoskeletal 16
    Protein for Human Keratin, type I cytoskeletal 16
    Protein for Human Keratin, type I cytoskeletal 16

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    Recovery
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    Linearity
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    References
    1. 1.
      "Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes."
      Raychaudhury A. , Marchuk D. , Lindhurst M. , Fuchs E.
      Mol. Cell. Biol.6:539-548(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "A group of type I keratin genes on human chromosome 17: characterization and expression."
      Rosenberg M. , Raychaudhury A. , Shows T.B. , le Beau M.M. , Fuchs E.
      Mol. Cell. Biol.8:722-736(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "cDNA cloning and bacterial expression of the human type I keratin 16."
      Paladini R.D. , Takahashi K. , Gant T.M. , Coulombe P.A.
      Biochem. Biophys. Res. Commun.215:517-523(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Keratinocyte.
    4. 4.
      "Cloning of multiple keratin 16 genes: genotype-phenotype correlation and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma."
      Smith F.J.D. , Fisher M.P. , Healy E. , Rees J.L. , McKusick V.A. , Bonifas J.M. , Epstein E.H. Jr. , Tan E. , Uitto J. , McLean W.H.I.
      Submitted (1998-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Mammary gland.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-134;VARIANT PC1 PRO-132
    9. 9.
      "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
      Rasmussen H.H. , van Damme J. , Puype M. , Gesser B. , Celis J.E. , Vandekerckhove J.
      Electrophoresis13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 137-148; 178-195 AND 264-283
      tissue: Keratinocyte.
    10. 10.
      "Cluster analysis of an extensive human breast cancer cell line protein expression map database."
      Harris R.A. , Yang A. , Stein R.C. , Lucy K. , Brusten L. , Herath A. , Parekh R. , Waterfield M.D. , O'Hare M.J. , Neville M.A. , Page M.J. , Zvelebil M.J.
      Proteomics2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MASS SPECTROMETRY
      tissue: Mammary cancer.
    11. 11.
      "Identification of trichoplein, a novel keratin filament-binding protein."
      Nishizawa M. , Izawa I. , Inoko A. , Hayashi Y. , Nagata K. , Yokoyama T. , Usukura J. , Inagaki M.
      J. Cell Sci.118:1081-1090(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TCHP
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Novel mutations in keratin 16 gene underly focal nonepidermolytic palmoplantar keratoderma (NEPPK) in two families."
      Shamsheer M.K. , Navsaria H.A. , Stevens H.P. , Ratnavel R.C. , Purkis P.E. , McLean W.H.I. , Cook L.J. , Griffiths W.A.D. , Geschmeissner S. , Spurr N. , Leigh I.M.
      Hum. Mol. Genet.4:1875-1881(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FNEPPK SER-125 AND CYS-127
    14. 14.
      "Novel proline substitution mutations in keratin 16 in two cases of pachyonychia congenita type 1."
      Smith F.J.D. , Del Monaco M. , Steijlen P.M. , Munro C.S. , Morvay M. , Coleman C.M. , Rietveld F.J.R. , Uitto J. , McLean W.H.I.
      Br. J. Dermatol.141:1010-1016(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PC1 PRO-122 AND PRO-127
    15. 15.
      "Cloning of multiple keratin 16 genes facilitates prenatal diagnosis of pachyonychia congenita type 1."
      Smith F.J. , McKusick V.A. , Nielsen K. , Pfendner E. , Uitto J. , McLean W.H.I.
      Prenat. Diagn.19:941-946(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PC1 SER-130 DEL
    16. 16.
      "Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma."
      Smith F.J. , Fisher M.P. , Healy E. , Rees J.L. , Bonifas J.M. , Epstein E.H. Jr. , Tan E.M. , Uitto J. , McLean W.H.I.
      Exp. Dermatol.9:170-177(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PC1 ARG-124
    17. 17.
      "A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus."
      Terrinoni A. , Puddu P. , Didona B. , De Laurenzi V. , Candi E. , Smith F.J. , McLean W.H.I. , Melino G.
      J. Invest. Dermatol.114:1136-1140(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT UPVN 104-GLY--ALA-107 DEL
    18. 18.
      "Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16."
      Connors J.B. , Rahil A.K. , Smith F.J.D. , McLean W.H.I. , Milstone L.M.
      Br. J. Dermatol.144:1058-1062(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PC1 ASN-354
    19. 19.
      "Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita."
      Terrinoni A. , Smith F.J.D. , Didona B. , Canzona F. , Paradisi M. , Huber M. , Hohl D. , David A. , Verloes A. , Leigh I.M. , Munro C.S. , Melino G. , McLean W.H.I.
      J. Invest. Dermatol.117:1391-1396(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PC1 THR-121 AND PC1 GLN-128
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