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Index > Protein center > PRKACB(Gene name) > Human
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  • PRKACB (Gene name),
  • cAMP-dependent protein kinase catalytic subunit beta (Protein name ),  KAPCB_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    PRKACB;
    Protein name:
    cAMP-dependent protein kinase catalytic subunit beta(PKA C-beta);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2.
    Function:
    Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
    Subcellular Location:
    Cytoplasm Cell membrane Nucleus Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.
    Protein Attributes:
    Sequence length:
    351
    Sequence:
    50:
    MGNAATAKKG | SEVESVKEFL | AKAKEDFLKK | WENPTQNNAG | LEDFERKKTL | 
    100:
    GTGSFGRVML | VKHKATEQYY | AMKILDKQKV | VKLKQIEHTL | NEKRILQAVN | 
    150:
    FPFLVRLEYA | FKDNSNLYMV | MEYVPGGEMF | SHLRRIGRFS | EPHARFYAAQ | 
    200:
    IVLTFEYLHS | LDLIYRDLKP | ENLLIDHQGY | IQVTDFGFAK | RVKGRTWTLC | 
    250:
    GTPEYLAPEI | ILSKGYNKAV | DWWALGVLIY | EMAAGYPPFF | ADQPIQIYEK | 
    300:
    IVSGKVRFPS | HFSSDLKDLL | RNLLQVDLTK | RFGNLKNGVS | DIKTHKWFAT | 
    350:
    TDWIAIYQRK | VEAPFIPKFR | GSGDTSNFDD | YEEEDIRVSI | TEKCAKEFGE | 
    351:
    F
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    KEGG:
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human PKA C-beta
    Cat.:
    E1987h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human PKA C-beta
    Cat.:
    E1987m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human PKA C-beta
    Cat.:
    E1987r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human PKA C-beta
    Cat.:
    E1987b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human PKA C-beta
    Cat.:
    E1987p
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PKA C-beta
    Cat.:
    U1987b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PKA C-beta
    Cat.:
    U1987h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PKA C-beta
    Cat.:
    U1987p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PKA C-beta
    Cat.:
    U1987m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PKA C-beta
    Cat.:
    U1987r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PKA C-beta
    Cat.:
    P1987Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PKA C-beta
    Polyclonal Antibody for Human PKA C-beta
    Cat.:
    P1987Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PKA C-beta
    Cat.:
    P1987Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PKA C-beta
    Monoclonal Antibody for Human PKA C-beta
    Monoclonal Antibody for Human PKA C-beta
    Monoclonal Antibody for Human PKA C-beta
    Monoclonal Antibody for Human PKA C-beta
    Monoclonal Antibody for Human PKA C-beta
    Protein for Human PKA C-beta
    Protein for Human PKA C-beta
    Protein for Human PKA C-beta
    Cat.:
    R1987h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human PKA C-beta
    Cat.:
    R1987m
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human PKA C-beta

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase."
      Beebe S.J. , Oyen O. , Sandberg M. , Froysa A. , Hansson V. , Jahnsen T.
      Mol. Endocrinol.4:465-475(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Testis.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 7)
      tissue: Retina.
      tissue: Salivary gland.
    3. 3.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6)
      tissue: Brain.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 9 AND 10)
      tissue: Brain.
      tissue: Thalamus.
      tissue: Trachea.
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2006-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 8)
      tissue: Brain.
    9. 9.
      "Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase."
      Orstavik S. , Reinton N. , Frengen E. , Langeland B.T. , Jahnsen T. , Skalhegg B.S.
      Eur. J. Biochem.268:5066-5073(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-30 (ISOFORMS 2; 5 AND 6);NUCLEOTIDE SEQUENCE [MRNA] OF 1-16 (ISOFORM 3);NUCLEOTIDE SEQUENCE [MRNA] OF 1-13 (ISOFORM 4);TISSUE SPECIFICITY
    10. 10.
      "c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-CB) gene."
      Wu K.-J. , Mattioli M. , Morse H.C. , Dalla-Favera R.
      Oncogene21:7872-7882(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-15 (ISOFORM 1);FUNCTION
    11. 11.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PJA2
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