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Index > Protein center > LAMA3(Gene name) > Human
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  • LAMA3 (Gene name),
  • Laminin subunit alpha-3 (Protein name ),  LAMA3_HUMAN from NCBI database.
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  • Gene name:
    LAMA3(LAMNA);
    Protein name:
    Laminin subunit alpha-3;
    Alternative:
    Epiligrin subunit alpha;Epiligrin 170 kDa subunit(E170);Laminin-5 subunit alpha;Kalinin subunit alpha;Laminin-7 subunit alpha;Laminin-6 subunit alpha;Nicein subunit alpha;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein), laminin-6 (laminin-311 or K-laminin) and laminin-7 (laminin-321 or KS-laminin).
    Function:
    Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.
    Subcellular Location:
    Secreted extracellular space extracellular matrix basement membrane Major component.
    Protein Attributes:
    Sequence length:
    3333
    Sequence:
    50:
    MAAAARPRGR | ALGPVLPPTP | LLLLVLRVLP | ACGATARDPG | AAAGLSLHPT | 
    100:
    YFNLAEAARI | WATATCGERG | PGEGRPQPEL | YCKLVGGPTA | PGSGHTIQGQ | 
    150:
    FCDYCNSEDP | RKAHPVTNAI | DGSERWWQSP | PLSSGTQYNR | VNLTLDLGQL | 
    200:
    FHVAYILIKF | ANSPRPDLWV | LERSVDFGST | YSPWQYFAHS | KVDCLKEFGR | 
    250:
    EANMAVTRDD | DVLCVTEYSR | IVPLENGEVV | VSLINGRPGA | KNFTFSHTLR | 
    300:
    EFTKATNIRL | RFLRTNTLLG | HLISKAQRDP | TVTRRYYYSI | KDISIGGQCV | 
    350:
    CNGHAEVCNI | NNPEKLFRCE | CQHHTCGETC | DRCCTGYNQR | RWRPAAWEQS | 
    400:
    HECEACNCHG | HASNCYYDPD | VERQQASLNT | QGIYAGGGVC | INCQHNTAGV | 
    450:
    NCEQCAKGYY | RPYGVPVDAP | DGCIPCSCDP | EHADGCEQGS | GRCHCKPNFH | 
    500:
    GDNCEKCAIG | YYNFPFCLRI | PIFPVSTPSS | EDPVAGDIKG | CDCNLEGVLP | 
    550:
    EICDAHGRCL | CRPGVEGPRC | DTCRSGFYSF | PICQACWCSA | LGSYQMPCSS | 
    600:
    VTGQCECRPG | VTGQRCDRCL | SGAYDFPHCQ | GSSSACDPAG | TINSNLGYCQ | 
    650:
    CKLHVEGPTC | SRCKLLYWNL | DKENPSGCSE | CKCHKAGTVS | GTGECRQGDG | 
    700:
    DCHCKSHVGG | DSCDTCEDGY | FALEKSNYFG | CQGCQCDIGG | ALSSMCSGPS | 
    750:
    GVCQCREHVV | GKVCQRPENN | YYFPDLHHMK | YEIEDGSTPN | GRDLRFGFDP | 
    800:
    LAFPEFSWRG | YAQMTSVQND | VRITLNVGKS | SGSLFRVILR | YVNPGTEAVS | 
    850:
    GHITIYPSWG | AAQSKEIIFL | PSKEPAFVTV | PGNGFADPFS | ITPGIWVACI | 
    900:
    KAEGVLLDYL | VLLPRDYYEA | SVLQLPVTEP | CAYAGPPQEN | CLLYQHLPVT | 
    950:
    RFPCTLACEA | RHFLLDGEPR | PVAVRQPTPA | HPVMVDLSGR | EVELHLRLRI | 
    1000:
    PQVGHYVVVV | EYSTEAAQLF | VVDVNVKSSG | SVLAGQVNIY | SCNYSVLCRS | 
    1050:
    AVIDHMSRIA | MYELLADADI | QLKGHMARFL | LHQVCIIPIE | EFSAEYVRPQ | 
    1100:
    VHCIASYGRF | VNQSATCVSL | AHETPPTALI | LDVLSGRPFP | HLPQQSSPSV | 
    1150:
    DVLPGVTLKA | PQNQVTLRGR | VPHLGRYVFV | IHFYQAAHPT | FPAQVSVDGG | 
    1200:
    WPRAGSFHAS | FCPHVLGCRD | QVIAEGQIEF | DISEPEVAAT | VKVPEGKSLV | 
    1250:
    LVRVLVVPAE | NYDYQILHKK | SMDKSLEFIT | NCGKNSFYLD | PQTASRFCKN | 
    1300:
    SARSLVAFYH | KGALPCECHP | TGATGPHCSP | EGGQCPCQPN | VIGRQCTRCA | 
    1350:
    TGHYGFPRCK | PCSCGRRLCE | EMTGQCRCPP | RTVRPQCEVC | ETHSFSFHPM | 
    1400:
    AGCEGCNCSR | RGTIEAAMPE | CDRDSGQCRC | KPRITGRQCD | RCASGFYRFP | 
    1450:
    ECVPCNCNRD | GTEPGVCDPG | TGACLCKENV | EGTECNVCRE | GSFHLDPANL | 
    1500:
    KGCTSCFCFG | VNNQCHSSHK | RRTKFVDMLG | WHLETADRVD | IPVSFNPGSN | 
    1550:
    SMVADLQELP | ATIHSASWVA | PTSYLGDKVS | SYGGYLTYQA | KSFGLPGDMV | 
    1600:
    LLEKKPDVQL | TGQHMSIIYE | ETNTPRPDRL | HHGRVHVVEG | NFRHASSRAP | 
    1650:
    VSREELMTVL | SRLADVRIQG | LYFTETQRLT | LSEVGLEEAS | DTGSGRIALA | 
    1700:
    VEICACPPAY | AGDSCQGCSP | GYYRDHKGLY | TGRCVPCNCN | GHSNQCQDGS | 
    1750:
    GICVNCQHNT | AGEHCERCQE | GYYGNAVHGS | CRACPCPHTN | SFATGCVVNG | 
    1800:
    GDVRCSCKAG | YTGTQCERCA | PGYFGNPQKF | GGSCQPCSCN | SNGQLGSCHP | 
    1850:
    LTGDCINQEP | KDSSPAEECD | DCDSCVMTLL | NDLATMGEQL | RLVKSQLQGL | 
    1900:
    SASAGLLEQM | RHMETQAKDL | RNQLLNYRSA | ISNHGSKIEG | LERELTDLNQ | 
    1950:
    EFETLQEKAQ | VNSRKAQTLN | NNVNRATQSA | KELDVKIKNV | IRNVHILLKQ | 
    2000:
    ISGTDGEGNN | VPSGDFSREW | AEAQRMMREL | RNRNFGKHLR | EAEADKRESQ | 
    2050:
    LLLNRIRTWQ | KTHQGENNGL | ANSIRDSLNE | YEAKLSDLRA | RLQEAAAQAK | 
    2100:
    QANGLNQENE | RALGAIQRQV | KEINSLQSDF | TKYLTTADSS | LLQTNIALQL | 
    2150:
    MEKSQKEYEK | LAASLNEARQ | ELSDKVRELS | RSAGKTSLVE | EAEKHARSLQ | 
    2200:
    ELAKQLEEIK | RNASGDELVR | CAVDAATAYE | NILNAIKAAE | DAANRAASAS | 
    2250:
    ESALQTVIKE | DLPRKAKTLS | SNSDKLLNEA | KMTQKKLKQE | VSPALNNLQQ | 
    2300:
    TLNIVTVQKE | VIDTNLTTLR | DGLHGIQRGD | IDAMISSAKS | MVRKANDITD | 
    2350:
    EVLDGLNPIQ | TDVERIKDTY | GRTQNEDFKK | ALTDADNSVN | KLTNKLPDLW | 
    2400:
    RKIESINQQL | LPLGNISDNM | DRIRELIQQA | RDAASKVAVP | MRFNGKSGVE | 
    2450:
    VRLPNDLEDL | KGYTSLSLFL | QRPNSRENGG | TENMFVMYLG | NKDASRDYIG | 
    2500:
    MAVVDGQLTC | VYNLGDREAE | LQVDQILTKS | ETKEAVMDRV | KFQRIYQFAR | 
    2550:
    LNYTKGATSS | KPETPGVYDM | DGRNSNTLLN | LDPENVVFYV | GGYPPDFKLP | 
    2600:
    SRLSFPPYKG | CIELDDLNEN | VLSLYNFKKT | FNLNTTEVEP | CRRRKEESDK | 
    2650:
    NYFEGTGYAR | VPTQPHAPIP | TFGQTIQTTV | DRGLLFFAEN | GDRFISLNIE | 
    2700:
    DGKLMVRYKL | NSELPKERGV | GDAINNGRDH | SIQIKIGKLQ | KRMWINVDVQ | 
    2750:
    NTIIDGEVFD | FSTYYLGGIP | IAIRERFNIS | TPAFRGCMKN | LKKTSGVVRL | 
    2800:
    NDTVGVTKKC | SEDWKLVRSA | SFSRGGQLSF | TDLGLPPTDH | LQASFGFQTF | 
    2850:
    QPSGILLDHQ | TWTRNLQVTL | EDGYIELSTS | DSGSPIFKSP | QTYMDGLLHY | 
    2900:
    VSVISDNSGL | RLLIDDQLLR | NSKRLKHISS | SRQSLRLGGS | NFEGCISNVF | 
    2950:
    VQRLSLSPEV | LDLTSNSLKR | DVSLGGCSLN | KPPFLMLLKG | STRFNKTKTF | 
    3000:
    RINQLLQDTP | VASPRSVKVW | QDACSPLPKT | QANHGALQFG | DIPTSHLLFK | 
    3050:
    LPQELLKPRS | QFAVDMQTTS | SRGLVFHTGT | KNSFMALYLS | KGRLVFALGT | 
    3100:
    DGKKLRIKSK | EKCNDGKWHT | VVFGHDGEKG | RLVVDGLRAR | EGSLPGNSTI | 
    3150:
    SIRAPVYLGS | PPSGKPKSLP | TNSFVGCLKN | FQLDSKPLYT | PSSSFGVSSC | 
    3200:
    LGGPLEKGIY | FSEEGGHVVL | AHSVLLGPEF | KLVFSIRPRS | LTGILIHIGS | 
    3250:
    QPGKHLCVYL | EAGKVTASMD | SGAGGTSTSV | TPKQSLCDGQ | WHSVAVTIKQ | 
    3300:
    HILHLELDTD | SSYTAGQIPF | PPASTQEPLH | LGGAPANLTT | LRIPVWKSFF | 
    3333:
    GCLRNIHVNH | IPVPVTEALE | VQGPVSLNGC | PDQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    UniGene:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Laminin subunit alpha-3
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    ELISA Kit for Human Laminin subunit alpha-3
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    E1345m
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    96T
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    CLIA Kit for Human Laminin subunit alpha-3
    Cat.:
    U1345h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Laminin subunit alpha-3
    Cat.:
    U1345m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Laminin subunit alpha-3
    Cat.:
    P1345Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Laminin subunit alpha-3
    Cat.:
    P1345Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Laminin subunit alpha-3
    Monoclonal Antibody for Human Laminin subunit alpha-3
    Protein for Human Laminin subunit alpha-3
    Protein for Human Laminin subunit alpha-3

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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4);DISEASE
    2. 2.
      "Characterization of laminin 5B and NH2-terminal proteolytic fragment of its alpha3B chain: promotion of cellular adhesion, migration, and proliferation."
      Kariya Y. , Yasuda C. , Nakashima Y. , Ishida K. , Tsubota Y. , Miyazaki K.
      J. Biol. Chem.279:24774-24784(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2);VARIANT GLY-2834
    3. 3.
      Stockwell T.B. , Busam D.A. , Ferriera S.M. , Brownley A.N. , Strausberg R.L. , Kirkness E.F. , Rogers Y.-H. , Levy S.
      Submitted (2007-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 5.
      "Cloning of the laminin alpha 3 chain gene (LAMA3) and identification of a homozygous deletion in a patient with Herlitz junctional epidermolysis bullosa."
      Vidal F. , Baudoin C. , Miquel C. , Galliano M.-F. , Christiano A.M. , Uitto J. , Ortonne J.-P. , Meneguzzi G.
      Genomics30:273-280(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-2858 (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 1528-2858 (ISOFORMS 1/2)
      tissue: Keratinocyte.
    5. 6.
      "Mutation in LAMA3 gene in a patient affected by H-Jeb."
      Aberdam D. , Vidal F. , Baudoin C. , Miquel C. , Ortonne J.-P. , Meneguzzi G.
      Submitted (1995-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1528-3333 (ISOFORMS 1/2);VARIANT GLY-2834
    6. 7.
      "Cloning of the LamA3 gene encoding the alpha 3 chain of the adhesive ligand epiligrin. Expression in wound repair."
      Ryan M.C. , Tizard R. , Vandevanter D.R. , Carter W.G.
      J. Biol. Chem.269:22779-22787(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-2834
      tissue: Keratinocyte.
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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