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Index > Protein center > TMPO(Gene name) > Human
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  • TMPO (Gene name),
  • Lamina-associated polypeptide 2, isoforms beta/gamma (Protein name ),  LAP2B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TMPO(LAP2);
    Protein name:
    Lamina-associated polypeptide 2, isoforms beta/gamma;
    Alternative:
    Thymopoietin-related peptide isoforms beta/gamma(TPRP isoforms beta/gamma);Thymopoietin, isoforms beta/gamma(TP beta/gamma);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL and chromosomes.
    Function:
    TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
    Subcellular Location:
    Nucleus inner membrane Single-pass type II membrane protein Tightly associated with the nuclear lamina.
    Protein Attributes:
    Sequence length:
    454
    Sequence:
    50:
    MPEFLEDPSV | LTKDKLKSEL | VANNVTLPAG | EQRKDVYVQL | YLQHLTARNR | 
    100:
    PPLPAGTNSK | GPPDFSSDEE | REPTPVLGSG | AAAAGRSRAA | VGRKATKKTD | 
    150:
    KPRQEDKDDL | DVTELTNEDL | LDQLVKYGVN | PGPIVGTTRK | LYEKKLLKLR | 
    200:
    EQGTESRSST | PLPTISSSAE | NTRQNGSNDS | DRYSDNEEDS | KIELKLEKRE | 
    250:
    PLKGRAKTPV | TLKQRRVEHN | QSYSQAGITE | TEWTSGSSKG | GPLQALTRES | 
    300:
    TRGSRRTPRK | RVETSEHFRI | DGPVISESTP | IAETIMASSN | ESLVVNRVTG | 
    350:
    NFKHASPILP | ITEFSDIPRR | APKKPLTRAE | VGEKTEERRV | ERDILKEMFP | 
    400:
    YEASTPTGIS | ASCRRPIKGA | AGRPLELSDF | RMEESFSSKY | VPKYVPLADV | 
    450:
    KSEKTKKGRS | IPVWIKILLF | VVVAVFLFLV | YQAMETNQVN | PFSNFLHVDP | 
    454:
    RKSN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    KEGG:
    UniGene:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    MSDS:
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    ELISA Kit for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Cat.:
    E1250h
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    Packing:
    96T
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    ELISA Kit for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Cat.:
    E1250m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Cat.:
    U1250r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Cat.:
    U1250h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Cat.:
    U1250m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Cat.:
    P1250Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Cat.:
    P1250Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Cat.:
    P1250Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Monoclonal Antibody for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Monoclonal Antibody for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Protein for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Cat.:
    R1250h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human Lamina-associated polypeptide 2, isoforms beta/gamma
    Protein for Human Lamina-associated polypeptide 2, isoforms beta/gamma

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Three distinct human thymopoietins are derived from alternatively spliced mRNAs."
      Harris C.A. , Andryuk P.J. , Cline S.W. , Chan H.K. , Natarajan A. , Siekierka J.J. , Goldstein G.
      Proc. Natl. Acad. Sci. U.S.A.91:6283-6287(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA AND GAMMA)
      tissue: Thymus.
    2. 2.
      "LAP2zeta binds BAF and suppresses LAP2beta-mediated transcriptional repression."
      Shaklai S. , Somech R. , Gal-Yam E.N. , Deshet-Unger N. , Moshitch-Moshkovitz S. , Hirschberg K. , Amariglio N. , Simon A.J. , Rechavi G.
      Eur. J. Cell Biol.87:267-278(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZETA);SUBCELLULAR LOCATION (ISOFORM ZETA)
    3. 3.
      Yu W. , Gibbs R.A.
      Submitted (1998-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA)
      tissue: Brain.
    4. 4.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA)
      tissue: Eye.
    6. 6.
      "Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2."
      Harris C.A. , Andryuk P.J. , Cline S.W. , Siekierka J.J. , Goldstein G.
      Genomics28:198-205(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-237 AND 313-454 (ISOFORMS BETA AND GAMMA)
    7. 7.
      "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin."
      Furukawa K. , Kondo T.
      Eur. J. Biochem.251:729-733(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LMNB1
    8. 8.
      "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication."
      Martins S. , Eikvar S. , Furukawa K. , Collas P.
      J. Cell Biol.160:177-188(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AKAP8L
    9. 9.
      "Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics."
      Dechat T. , Vlcek S. , Foisner R.
      J. Struct. Biol.129:335-345(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY
    10. 10.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."
      Giorgianni F. , Zhao Y. , Desiderio D.M. , Beranova-Giorgianni S.
      Electrophoresis28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Prostate cancer.
    12. 12.
      "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R. , Zhu Z. , Chan K.C. , Issaq H.J. , Dimitrov D.S. , Veenstra T.D.
      J. Proteome Res.6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."
      Tang L.-Y. , Deng N. , Wang L.-S. , Dai J. , Wang Z.-L. , Jiang X.-S. , Li S.-J. , Li L. , Sheng Q.-H. , Wu D.-Q. , Li L. , Zeng R.
      Mol. Cell. Proteomics6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    14. 14.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-74; SER-306 AND SER-315;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M. , Ovelleiro D. , Casas V. , Gay M. , Abian J.
      J. Proteome Res.7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: T-cell.
    16. 16.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-74 AND SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-57; SER-66; SER-67; THR-74; SER-79; THR-160; THR-164; SER-177; SER-180; SER-306; SER-315; SER-362 AND SER-385;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G. , Ye M. , Zhou H. , Jiang X. , Feng S. , Jiang X. , Tian R. , Wan D. , Zou H. , Gu J.
      Proteomics8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    19. 19.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-67; THR-74; SER-79; THR-154; THR-160; SER-292 AND SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    21. 21.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-74; SER-156; THR-160; THR-211; SER-265; SER-306; THR-312 AND SER-315;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59; THR-74 AND SER-184;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    24. 24.
      "Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA."
      Cai M. , Huang Y. , Ghirlando R. , Wilson K.L. , Craigie R. , Clore G.M.
      EMBO J.20:4399-4407(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-169
    25. 25.
      "Structural characterization of the LEM motif common to three human inner nuclear membrane proteins."
      Laguri C. , Gilquin B. , Wolff N. , Romi-Lebrun R. , Courchay K. , Callebaut I. , Worman H.J. , Zinn-Justin S.
      Structure9:503-511(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-57 AND 103-159
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