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Index > Protein center > LILRB1(Gene name) > Human
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  • LILRB1 (Gene name),
  • Leukocyte immunoglobulin-like receptor subfamily B member 1 (Protein name ),  LIRB1_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    LILRB1(ILT2;LIR1;MIR7);
    Protein name:
    Leukocyte immunoglobulin-like receptor subfamily B member 1(LIR-1;Leukocyte immunoglobulin-like receptor 1);
    Alternative:
    Immunoglobulin-like transcript 2(ILT-2);CD85 antigen-like family member J;Monocyte/macrophage immunoglobulin-like receptor 7(MIR-7);
    CD:
    CD85j;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds PTPN6 when phosphorylated. Binds FCER1A and FCGR1A.
    Function:
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    650
    Sequence:
    50:
    MTPILTVLIC | LGLSLGPRTH | VQAGHLPKPT | LWAEPGSVIT | QGSPVTLRCQ | 
    100:
    GGQETQEYRL | YREKKTALWI | TRIPQELVKK | GQFPIPSITW | EHAGRYRCYY | 
    150:
    GSDTAGRSES | SDPLELVVTG | AYIKPTLSAQ | PSPVVNSGGN | VILQCDSQVA | 
    200:
    FDGFSLCKEG | EDEHPQCLNS | QPHARGSSRA | IFSVGPVSPS | RRWWYRCYAY | 
    250:
    DSNSPYEWSL | PSDLLELLVL | GVSKKPSLSV | QPGPIVAPEE | TLTLQCGSDA | 
    300:
    GYNRFVLYKD | GERDFLQLAG | AQPQAGLSQA | NFTLGPVSRS | YGGQYRCYGA | 
    350:
    HNLSSEWSAP | SDPLDILIAG | QFYDRVSLSV | QPGPTVASGE | NVTLLCQSQG | 
    400:
    WMQTFLLTKE | GAADDPWRLR | STYQSQKYQA | EFPMGPVTSA | HAGTYRCYGS | 
    450:
    QSSKPYLLTH | PSDPLELVVS | GPSGGPSSPT | TGPTSTSGPE | DQPLTPTGSD | 
    500:
    PQSGLGRHLG | VVIGILVAVI | LLLLLLLLLF | LILRHRRQGK | HWTSTQRKAD | 
    550:
    FQHPAGAVGP | EPTDRGLQWR | SSPAADAQEE | NLYAAVKHTQ | PEDGVEMDTR | 
    600:
    SPHDEDPQAV | TYAEVKHSRP | RREMASPPSP | LSGEFLDTKD | RQAEEDRQMD | 
    650:
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    String:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human LIR-1
    Cat.:
    E9192h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human LIR-1
    Cat.:
    U9192h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human LIR-1
    Cat.:
    P9192Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human LIR-1
    Protein for Human LIR-1

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors."
      Wagtmann N. , Rojo S. , Eichler E. , Mohrenweiser H. , Long E.O.
      Curr. Biol.7:615-618(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
    2. 2.
      "A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules."
      Cosman D. , Fanger N. , Borges L. , Kubin M. , Chin W. , Peterson L. , Hsu M.-L.
      Immunity7:273-282(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);VARIANTS PRO-68; THR-142; ILE-155 AND LYS-625;INTERACTION WITH H301 AND PTPN6;PHOSPHORYLATION;TISSUE SPECIFICITY;FUNCTION
      tissue: Lymphoblast.
    3. 3.
      "Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4."
      Liu W.R. , Kim J. , Nwankwo C. , Ashworth L.K. , Arm J.P.
      Immunogenetics51:659-669(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    4. 4.
      "Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes."
      Jones D.C. , Roghanian A. , Brown D.P. , Chang C. , Allen R.L. , Trowsdale J. , Young N.T.
      Eur. J. Immunol.39:3195-3206(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);ALTERNATIVE SPLICING;SUBCELLULAR LOCATION (ISOFORM 5);VARIANTS PRO-68; THR-93; THR-142 AND ILE-155
    5. 5.
      "LILRB1 polymorphism and surface phenotypes of natural killer cells."
      Davidson C.L. , Li N.L. , Burshtyn D.N.
      Hum. Immunol.71:942-949(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-68; THR-93; THR-142; ILE-155 AND LYS-625
    6. 6.
      Canavez F.C.
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    7. 7.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS PRO-68; THR-142; ILE-155 AND LYS-625
      tissue: B-cell.
    9. 9.
      "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes."
      Fanger N.A. , Cosman D. , Peterson L. , Braddy S.C. , Maliszewski C.R. , Borges L.
      Eur. J. Immunol.28:3423-3434(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN6 AND FCGR1A;PHOSPHORYLATION;TISSUE SPECIFICITY;FUNCTION
    10. 10.
      "The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18."
      Chapman T.L. , Heikeman A.P. , Bjorkman P.J.
      Immunity11:603-613(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-5 PROTEIN UL18
    11. 11.
      "Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor."
      Bellon T. , Kitzig F. , Sayos J. , Lopez-Botet M.
      J. Immunol.168:3351-3359(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-533; TYR-614 AND TYR-644;MUTAGENESIS OF TYR-533; TYR-562; TYR-614 AND TYR-644;INTERACTION WITH FCER1A;FUNCTION
    12. 12.
      "Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2)."
      Chapman T.L. , Heikema A.P. , West A.P. Jr. , Bjorkman P.J.
      Immunity13:727-736(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 25-221
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