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Index > Protein center > LILRB2(Gene name) > Human
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  • LILRB2 (Gene name),
  • Leukocyte immunoglobulin-like receptor subfamily B member 2 (Protein name ),  LIRB2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    LILRB2(ILT4;LIR2;MIR10);
    Protein name:
    Leukocyte immunoglobulin-like receptor subfamily B member 2(LIR-2;Leukocyte immunoglobulin-like receptor 2);
    Alternative:
    Immunoglobulin-like transcript 4(ILT-4);CD85 antigen-like family member D;Monocyte/macrophage immunoglobulin-like receptor 10(MIR-10);
    CD:
    CD85d;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds PTPN6 when phosphorylated. Binds FCGR1A.
    Function:
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    598
    Sequence:
    50:
    MTPIVTVLIC | LGLSLGPRTH | VQTGTIPKPT | LWAEPDSVIT | QGSPVTLSCQ | 
    100:
    GSLEAQEYRL | YREKKSASWI | TRIRPELVKN | GQFHIPSITW | EHTGRYGCQY | 
    150:
    YSRARWSELS | DPLVLVMTGA | YPKPTLSAQP | SPVVTSGGRV | TLQCESQVAF | 
    200:
    GGFILCKEGE | EEHPQCLNSQ | PHARGSSRAI | FSVGPVSPNR | RWSHRCYGYD | 
    250:
    LNSPYVWSSP | SDLLELLVPG | VSKKPSLSVQ | PGPVVAPGES | LTLQCVSDVG | 
    300:
    YDRFVLYKEG | ERDLRQLPGR | QPQAGLSQAN | FTLGPVSRSY | GGQYRCYGAH | 
    350:
    NLSSECSAPS | DPLDILITGQ | IRGTPFISVQ | PGPTVASGEN | VTLLCQSWRQ | 
    400:
    FHTFLLTKAG | AADAPLRLRS | IHEYPKYQAE | FPMSPVTSAH | AGTYRCYGSL | 
    450:
    NSDPYLLSHP | SEPLELVVSG | PSMGSSPPPT | GPISTPAGPE | DQPLTPTGSD | 
    500:
    PQSGLGRHLG | VVIGILVAVV | LLLLLLLLLF | LILRHRRQGK | HWTSTQRKAD | 
    550:
    FQHPAGAVGP | EPTDRGLQWR | SSPAADAQEE | NLYAAVKDTQ | PEDGVEMDTR | 
    598:
    AAASEAPQDV | TYAQLHSLTL | RRKATEPPPS | QEREPPAEPS | IYATLAIH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    KEGG:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human LIR-2
    Cat.:
    E7745h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human LIR-2
    Cat.:
    U7745h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human LIR-2
    Cat.:
    P7745Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human LIR-2
    Protein for Human LIR-2

    R&D Technical Data

    s

    s
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤7.1%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤12.7%

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of LIRB2 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-107%

    95-104%

    93-103%

    EDTA plasma(n=5)

    89-107%

    93-105%

    90-104%

    92-106%

    heparin plasma(n=5)

    93-104%

     

    94-101%

    91-106%

    94-100%

     

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells."
      Colonna M. , Navarro F. , Bellon T. , Llano M. , Garcia P. , Samaridis J. , Angman L. , Cella M. , Lopez-Botet M.
      J. Exp. Med.186:1809-1818(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322
    2. 2.
      "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
      Borges L. , Hsu M.-L. , Fanger N. , Kubin M. , Cosman D.
      J. Immunol.159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;FUNCTION;VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322
      tissue: Dendritic cell.
      tissue: Peripheral blood monocyte.
    3. 3.
      Canavez F.C.
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322
    4. 4.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322
      tissue: Peripheral blood leukocyte.
    6. 6.
      "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes."
      Fanger N.A. , Cosman D. , Peterson L. , Braddy S.C. , Maliszewski C.R. , Borges L.
      Eur. J. Immunol.28:3423-3434(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN6 AND FCGR1A;PHOSPHORYLATION;TISSUE SPECIFICITY;FUNCTION
    7. 7.
      "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4."
      Chang C.C. , Ciubotariu R. , Manavalan J.S. , Yuan J. , Colovai A.I. , Piazza F. , Lederman S. , Colonna M. , Cortesini R. , Dalla-Favera R. , Suciu-Foca N.
      Nat. Immunol.3:237-243(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G."
      Shiroishi M. , Tsumoto K. , Amano K. , Shirakihara Y. , Colonna M. , Braud V.M. , Allan D.S.J. , Makadzange A. , Rowland-Jones S. , Willcox B.E. , Jones E.Y. , van der Merwe P.A. , Kumagai I. , Maenaka K.
      Proc. Natl. Acad. Sci. U.S.A.100:8856-8861(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TYPE I MHC ALLELES;FUNCTION
    9. 9.
      "Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the human cytomegalovirus class I MHC homolog UL18."
      Willcox B.E. , Thomas L.M. , Chapman T.L. , Heikema A.P. , West A.P. Jr. , Bjorkman P.J.
      BMC Struct. Biol.2:6-6(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 22-219
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