LRRK2 ELISA Kit for Human(Homo sapiens) | EIAab.comLRRK2 ELISA Kit for Human(Homo sapiens)

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LRRK2 (Gene name),

Leucine-rich repeat serine/threonine-protein kinase 2 (Protein name ), LRRK2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

LRRK2(PARK8);

Protein name:

Leucine-rich repeat serine/threonine-protein kinase 2;

Alternative:

Dardarin;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PARK2.

Function:

Probable protein kinase whose role is not yet known. May play a role in the phosphorylation of proteins central to Parkinson disease. May also have GTPase activity.

Subcellular Location:

Cytoplasm Membrane Peripheral membrane protein Localized in the cytoplasm and associated with cellular membrane structures. Associates with the mitochondrial outer membrane.

Protein Attributes:

Sequence length:

2527

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2527:

PHEVQNLEKH | IEVRKELAEK | MRRTSVE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000298910

UniGene:

Hs.187636

MIM:

168600

KEGG:

hsa:120892

String:

Q5S007

Pfam:

PF00560

SMR:

Q5S007

Uniprot:

Q5S007

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ELISA Kit for Human Leucine-rich repeat serine/threonine-protein kinase 2

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E1515h

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96T

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ELISA Kit for Human Leucine-rich repeat serine/threonine-protein kinase 2

Cat.:

E1515m

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Packing:

96T

CLIA Kit for Human Leucine-rich repeat serine/threonine-protein kinase 2

Cat.:

U1515h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Leucine-rich repeat serine/threonine-protein kinase 2

Cat.:

U1515m

Price:

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MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Leucine-rich repeat serine/threonine-protein kinase 2

Cat.:

P1515Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Leucine-rich repeat serine/threonine-protein kinase 2

Cat.:

P1515Rb-h

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Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Leucine-rich repeat serine/threonine-protein kinase 2

Protein for Human Leucine-rich repeat serine/threonine-protein kinase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology."
Zimprich A. , Biskup S. , Leitner P. , Lichtner P. , Farrer M. , Lincoln S.J. , Kachergus J.M. , Hulihan M.M. , Uitti R.J. , Calne D.B. , Stoessl A.J. , Pfeiffer R.F. , Patenge N. , Carballo Carbajal I. , Vieregge P. , Asmus F. , Mueller-Myhsok B. , Dickson D.W. , more...
Neuron44:601-607(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;VARIANTS PARK8 VAL-1122; CYS-1441; CYS-1699 AND THR-2020
tissue: Brain.
2.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2128-2527
tissue: Testis.
4.

"PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation."
Adams J.R. , van Netten H. , Schulzer M. , Mak E. , McKenzie J. , Strongosky A. , Sossi V. , Ruth T.J. , Lee C.S. , Farrer M. , Gasser T. , Uitti R.J. , Calne D.B. , Wszolek Z.K. , Stoessl A.J.
Brain128:2777-2785(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
5.

"The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity."
Gloeckner C.J. , Kinkl N. , Schumacher A. , Braun R.J. , O'Neill E. , Meitinger T. , Kolch W. , Prokisch H. , Ueffing M.
Hum. Mol. Genet.15:223-232(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANT PARK8 THR-2020
6.

"LRRK2 mutations are not common in Alzheimer's disease."
Toft M. , Sando S.B. , Melquist S. , Ross O.A. , White L.R. , Aasly J.O. , Farrer M.J.
Mech. Ageing Dev.126:1201-1205(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
7.

"Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity."
West A.B. , Moore D.J. , Biskup S. , Bugayenko A. , Smith W.W. , Ross C.A. , Dawson V.L. , Dawson T.M.
Proc. Natl. Acad. Sci. U.S.A.102:16842-16847(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANTS PARK8 CYS-1441 AND SER-2019
8.

"Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin and mutant LRRK2 induces neuronal degeneration."
Smith W.W. , Pei Z. , Jiang H. , Moore D.J. , Liang Y. , West A.B. , Dawson V.L. , Dawson T.M. , Ross C.A.
Proc. Natl. Acad. Sci. U.S.A.102:18676-18681(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH PARK2;POSSIBLE FUNCTION
9.

"LRRK2 expression linked to dopamine-innervated areas."
Galter D. , Westerlund M. , Carmine A. , Lindqvist E. , Sydow O. , Olson L.
Ann. Neurol.59:714-719(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
10.

"Localization of LRRK2 to membranous and vesicular structures in mammalian brain."
Biskup S. , Moore D.J. , Celsi F. , Higashi S. , West A.B. , Andrabi S.A. , Kurkinen K. , Yu S.W. , Savitt J.M. , Waldvogel H.J. , Faull R.L. , Emson P.C. , Torp R. , Ottersen O.P. , Dawson T.M. , Dawson V.L.
Ann. Neurol.60:557-569(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
11.

"The familial Parkinsonism gene LRRK2 regulates neurite process morphology."
MacLeod D. , Dowman J. , Hammond R. , Leete T. , Inoue K. , Abeliovich A.
Neuron52:587-593(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF VARIANTS PARK8 GLY-1441; CYS-1699; SER-2019 AND THR-2020;VARIANT MET-1906
12.

"Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity."
Zach S. , Felk S. , Gillardon F.
PLoS ONE5:E13191-E13191(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death."
Angeles D.C. , Gan B.H. , Onstead L. , Zhao Y. , Lim K.L. , Dachsel J. , Melrose H. , Farrer M. , Wszolek Z.K. , Dickson D.W. , Tan E.K.
Hum. Mutat.32:1390-1397(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PRDX3;CHARACTERIZATION OF VARIANT PARK8 SER-2019
14.

"Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP."
Gomez-Suaga P. , Luzon-Toro B. , Churamani D. , Zhang L. , Bloor-Young D. , Patel S. , Woodman P.G. , Churchill G.C. , Hilfiker S.
Hum. Mol. Genet.21:511-525(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TPCN2
15.

"Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers."
Civiero L. , Vancraenenbroeck R. , Belluzzi E. , Beilina A. , Lobbestael E. , Reyniers L. , Gao F. , Micetic I. , De Maeyer M. , Bubacco L. , Baekelandt V. , Cookson M.R. , Greggio E. , Taymans J.M.
PLoS ONE7:E43472-E43472(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;AUTOPHOSPHORYLATION
16.

"RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk."
MacLeod D.A. , Rhinn H. , Kuwahara T. , Zolin A. , Di Paolo G. , McCabe B.D. , MacCabe B.D. , Marder K.S. , Honig L.S. , Clark L.N. , Small S.A. , Abeliovich A.
Neuron77:425-439(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RETROGRADE TRANSPORT;INTERACTION WITH RAB29 AND VPS35;SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANT PARK8 SER-2019;CHARACTERIZATION OF VARIANT MET-1906
17.

"Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease."
Paisan-Ruiz C. , Jain S. , Evans E.W. , Gilks W.P. , Simon J. , van der Brug M. , Lopez de Munain A. , Aparicio S. , Gil A.M. , Khan N.L. , Johnson J. , Martinez J.R. , Nicholl D. , Carrera I.M. , Pena A.S. , de Silva R. , Lees A.J. , Marti-Masso J.F. , more...
Neuron44:595-600(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK8 GLY-1441 AND CYS-1699;TISSUE SPECIFICITY
18.

"Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations."
Kachergus J.M. , Mata I.F. , Hulihan M. , Taylor J.P. , Lincoln S. , Aasly J.O. , Gibson J.M. , Ross O.A. , Lynch T. , Wiley J. , Payami H. , Nutt J. , Maraganore D.M. , Czyzewski K. , Styczynska M. , Wszolek Z.K. , Farrer M.J. , Toft M.
Am. J. Hum. Genet.76:672-680(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019
19.

"Clinical and positron emission tomography of Parkinson's disease caused by LRRK2."
Hernandez D.G. , Paisan-Ruiz C. , McInerney-Leo A. , Jain S. , Meyer-Lindenberg A. , Evans E.W. , Berman K.F. , Johnson J. , Auburger G. , Schaeffer A.A. , Lopez G.J. , Nussbaum R.L. , Singleton A.B.
Ann. Neurol.57:453-456(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019
20.

"Clinical features of LRRK2-associated Parkinson's disease in central Norway."
Aasly J.O. , Toft M. , Fernandez-Mata I. , Kachergus J.M. , Hulihan M. , White L.R. , Farrer M.J.
Ann. Neurol.57:762-765(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8/PD SER-2019
21.

"G2019S LRRK2 mutation in French and North African families with Parkinson's disease."
French Parkinson's disease genetics study group , Lesage S. , Ibanez P. , Lohmann E. , Pollak P. , Tison F. , Tazir M. , Leutenegger A.-L. , Guimaraes J. , Bonnet A.-M. , Agid Y. , Duerr A. , Brice A.
Ann. Neurol.58:784-787(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019
22.

"An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family."
Funayama M. , Hasegawa K. , Ohta E. , Kawashima N. , Komiyama M. , Kowa H. , Tsuji S. , Obata F.
Ann. Neurol.57:918-921(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 THR-2020
23.

"Genetic and clinical identification of Parkinson's disease patients with LRRK2 G2019S mutation."
Deng H. , Le W. , Guo Y. , Hunter C.B. , Xie W. , Jankovic J.
Ann. Neurol.57:933-934(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019
24.

"Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease."
Berg D. , Schweitzer K. , Leitner P. , Zimprich A. , Lichtner P. , Belcredi P. , Bruessel T. , Schulte C. , Maass S. , Naegele T.
Brain128:3000-3011(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK8 MET-793; ARG-930; CYS-1096 THR-1228; SER-2019 AND THR-2020;VARIANT LYS-551
25.

"Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data."
Khan N.L. , Jain S. , Lynch J.M. , Pavese N. , Abou-Sleiman P.M. , Holton J.L. , Healy D.G. , Gilks W.P. , Sweeney M.G. , Ganguly M. , Gibbons V. , Gandhi S. , Vaughan J. , Eunson L.H. , Katzenschlager R. , Gayton J. , Lennox G. , Revesz T. , more...
Brain128:2786-2796(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK8 CYS-1699; HIS-1941; SER-2019 AND ILE-2356
26.

"Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease."
Di Fonzo A. , Tassorelli C. , De Mari M. , Chien H.F. , Ferreira J. , Rohe C.F. , Riboldazzi G. , Antonini A. , Albani G. , Mauro A. , Marconi R. , Abbruzzese G. , Lopiano L. , Fincati E. , Guidi M. , Marini P. , Stocchi F. , Onofrj M. , more...
Eur. J. Hum. Genet.14:322-331(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK8 VAL-1371; CYS-1441 AND SER-2019
27.

"The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor."
Goldwurm S. , Di Fonzo A. , Simons E.J. , Rohe C.F. , Zini M. , Canesi M. , Tesei S. , Zecchinelli A. , Antonini A. , Mariani C. , Meucci N. , Sacilotto G. , Sironi F. , Salani G. , Ferreira J. , Chien H.F. , Fabrizio E. , Vanacore N. , more...
J. Med. Genet.42:E65-E65(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019
28.

"Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease."
The Parkinson study group-PROGENI investigators , Nichols W.C. , Pankratz N. , Hernandez D. , Paisan-Ruiz C. , Jain S. , Halter C.A. , Michaels V.E. , Reed T. , Rudolph A. , Shults C.W. , Singleton A. , Foroud T.
Lancet365:410-412(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019
29.

"A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease."
The Italian Parkinson genetics network , Di Fonzo A. , Rohe C.F. , Ferreira J. , Chien H.F. , Vacca L. , Stocchi F. , Guedes L. , Fabrizio E. , Manfredi M. , Vanacore N. , Goldwurm S. , Breedveld G.J. , Sampaio C. , Meco G. , Barbosa E. , Oostra B.A. , Bonifati V.
Lancet365:412-415(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019
30.

"A common LRRK2 mutation in idiopathic Parkinson's disease."
Gilks W.P. , Abou-Sleiman P.M. , Gandhi S. , Jain S. , Singleton A. , Lees A.J. , Shaw K. , Bhatia K.P. , Bonifati V. , Quinn N.P. , Lynch J.M. , Healy D.G. , Holton J.L. , Revesz T. , Wood N.W.
Lancet365:415-416(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019
31.

"LRRK2 mutations and Parkinsonism."
Toft M. , Mata I.F. , Kachergus J.M. , Ross O.A. , Farrer M.J.
Lancet365:1229-1230(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019
32.

"Escaping Parkinson's disease: a neurologically healthy octogenarian with the LRRK2 G2019S mutation."
Kay D.M. , Kramer P. , Higgins D.S. , Zabetian C.P. , Payami H.
Mov. Disord.20:1077-1078(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-2019
33.

"Parkinson's disease and LRRK2: frequency of a common mutation in U.S. movement disorder clinics."
Kay D.M. , Zabetian C.P. , Factor S.A. , Nutt J.G. , Samii A. , Griffith A. , Bird T.D. , Kramer P. , Higgins D.S. , Payami H.
Mov. Disord.21:519-523(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019
34.

"Lrrk2 pathogenic substitutions in Parkinson's disease."
Mata I.F. , Kachergus J.M. , Taylor J.P. , Lincoln S. , Aasly J. , Lynch T. , Hulihan M.M. , Cobb S.A. , Wu R.-M. , Lu C.-S. , Lahoz C. , Wszolek Z.K. , Farrer M.J.
Neurogenetics6:171-177(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK8 CYS-1441; GLY-1441; HIS-1441; GLN-1514; SER-1542; GLU-1598; CYS-1699; THR-1869; THR-2012; SER-2019; THR-2020 AND ARG-2385;VARIANTS PRO-119; LYS-551; VAL-723; MET-793; VAL-1122; ALA-1262; HIS-1398; PRO-1628; THR-1646; THR-1647; ASP-2081; LEU-2119; ILE-2261 AND THR-2397
35.

"LRRK2 gene in Parkinson disease: mutation analysis and case control association study."
Paisan-Ruiz C. , Lang A.E. , Kawarai T. , Sato C. , Salehi-Rad S. , Fisman G.K. , Al-Khairallah T. , St George-Hyslop P.H. , Singleton A. , Rogaeva E.
Neurology65:696-700(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK8 VAL-1371 AND SER-2019;VARIANTS HIS-1398 AND THR-2397
36.

"Analysis of LRRK2 functional domains in nondominant Parkinson disease."
Skipper L. , Shen H. , Chua E. , Bonnard C. , Kolatkar P. , Tan L.C.S. , Jamora R.D. , Puvan K. , Puong K.Y. , Zhao Y. , Pavanni R. , Wong M.C. , Yuen Y. , Farrer M. , Liu J.J. , Tan E.K.
Neurology65:1319-1321(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 GLN-1067
37.

"LRRK2 mutations in Parkinson disease."
Farrer M. , Stone J. , Mata I.F. , Lincoln S. , Kachergus J. , Hulihan M. , Strain K.J. , Maraganore D.M.
Neurology65:738-740(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK8 MET-793; THR-1869 AND SER-2019
38.

"A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations."
Zabetian C.P. , Samii A. , Mosley A.D. , Roberts J.W. , Leis B.C. , Yearout D. , Raskind W.H. , Griffith A.
Neurology65:741-744(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK8 CYS-1441; HIS-1441 AND SER-2019
39.

"LRRK2 R1441G in Spanish patients with Parkinson's disease."
Mata I.F. , Taylor J.P. , Kachergus J. , Hulihan M. , Huerta C. , Lahoz C. , Blazquez M. , Guisasola L.M. , Salvador C. , Ribacoba R. , Martinez C. , Farrer M. , Alvarez V.
Neurosci. Lett.382:309-311(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 GLY-1441
40.

"LRRK2 G2019S is a common mutation in Spanish patients with late-onset Parkinson's disease."
Infante J. , Rodriguez E. , Combarros O. , Mateo I. , Fontalba A. , Pascual J. , Oterino A. , Polo J.M. , Leno C. , Berciano J.
Neurosci. Lett.395:224-226(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019
41.

"Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PD."
Gosal D. , Ross O.A. , Wiley J. , Irvine G.B. , Johnston J.A. , Toft M. , Mata I.F. , Kachergus J. , Hulihan M. , Taylor J.P. , Lincoln S.J. , Farrer M.J. , Lynch T. , Mark Gibson J.
Parkinsonism Relat. Disord.11:349-352(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019
42.

"LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance."
Gaig C. , Ezquerra M. , Marti M.J. , Munoz E. , Valldeoriola F. , Tolosa E.
Arch. Neurol.63:377-382(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK8 CYS-1441; GLY-1441 AND SER-2019
43.

"The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence."
Tan E.K. , Zhao Y. , Skipper L. , Tan M.G. , Di Fonzo A. , Sun L. , Fook-Chong S. , Tang S. , Chua E. , Yuen Y. , Tan L. , Pavanni R. , Wong M.C. , Kolatkar P. , Lu C.S. , Bonifati V. , Liu J.J.
Hum. Genet.120:857-863(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT ARG-2385;ASSOCIATION WITH PARKINSON DISEASE
44.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-119; VAL-419; LYS-551; VAL-723; HIS-1398; GLN-1514; SER-1542; GLN-1550 AND PRO-1723
45.

"Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls."
Paisan-Ruiz C. , Nath P. , Washecka N. , Gibbs J.R. , Singleton A.B.
Hum. Mutat.29:485-490(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK8 VAL-712; LEU-1728; HIS-1728; SER-2019; MET-2141; HIS-2143 AND HIS-2466;VARIANTS SER-228; VAL-716; GLU-871; PHE-1870 AND LYS-2395
46.

"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Varela I. , Tarpey P. , Raine K. , Huang D. , Ong C.K. , Stephens P. , Davies H. , Jones D. , Lin M.L. , Teague J. , Bignell G. , Butler A. , Cho J. , Dalgliesh G.L. , Galappaththige D. , Greenman C. , Hardy C. , Jia M. , more...
Nature469:539-542(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-1359
47.

"Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson's disease."
Bardien S. , Lesage S. , Brice A. , Carr J.
Parkinsonism Relat. Disord.17:501-508(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANTS PRO-1628 AND ARG-2385 WITH PARKINSON DISEASE
48.

"Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe."
Rubio J.P. , Topp S. , Warren L. , St Jean P.L. , Wegmann D. , Kessner D. , Novembre J. , Shen J. , Fraser D. , Aponte J. , Nangle K. , Cardon L.R. , Ehm M.G. , Chissoe S.L. , Whittaker J.C. , Nelson M.R. , Mooser V.E.
Hum. Mutat.33:1087-1098(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LYS-551; VAL-723; HIS-1398; GLN-1514; SER-1542; PRO-1628; THR-1646; THR-1647; ASP-2081 AND THR-2397
49.

"Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease."
Kilarski L.L. , Pearson J.P. , Newsway V. , Majounie E. , Knipe M.D. , Misbahuddin A. , Chinnery P.F. , Burn D.J. , Clarke C.E. , Marion M.H. , Lewthwaite A.J. , Nicholl D.J. , Wood N.W. , Morrison K.E. , Williams-Gray C.H. , Evans J.R. , Sawcer S.J. , Barker R.A. , more...
Mov. Disord.27:1522-1529(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK8 SER-2019

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