MADCAM1 ELISA Kit for Human(Homo sapiens) | EIAab.comMADCAM1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MADCAM1(Gene name) > Human

MADCAM1 (Gene name),

Mucosal addressin cell adhesion molecule 1 (Protein name ), MADCA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

MADCAM1;

Protein name:

Mucosal addressin cell adhesion molecule 1(MAdCAM-1;hMAdCAM-1);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

382

Sequence:

50:

100:

150:

200:

250:

300:

350:

382:

DDTHPPASLR | LLPQVSAWAG | LRGTGQVGIS | PS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q13477

KEGG:

hsa:8174

MIM:

102670

STRING:

9606.ENSP00000215637

UniGene:

Hs.102598

Pfam:

PF09085

SMR:

Q13477

Uniprot:

Q13477

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ELISA Kit for Human MAdCAM-1

Cat.:

E1521h

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Packing:

96T

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ELISA Kit for Human MAdCAM-1

Cat.:

E1521r

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96T

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ELISA Kit for Human MAdCAM-1

Cat.:

E1521m

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MSDS:

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Packing:

96T

CLIA Kit for Human MAdCAM-1

Cat.:

U1521r

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Manual:

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Packing:

96T

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CLIA Kit for Human MAdCAM-1

Cat.:

U1521h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human MAdCAM-1

Cat.:

U1521m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human MAdCAM-1

Cat.:

P1521Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MAdCAM-1

Cat.:

P1521Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MAdCAM-1

Cat.:

P1521Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human MAdCAM-1

Protein for Human MAdCAM-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Novel Inhibitors of Leukocyte Transendothelial Migration"

T Getter, R Margalit, S Kahremany, et al.

From:Bioorganic Chemistry

References

1.

"Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts."
Leung E. , Greene J. , Ni J. , Raymond L.G. , Lehnert K. , Langley R. , Krissansen G.W.
Immunol. Cell Biol.74:490-496(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING;TISSUE SPECIFICITY
tissue: Fetal brain.
2.

"Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences."
Shyjan A.M. , Bertagnolli M. , Kenney C.J. , Briskin M.J.
J. Immunol.156:2851-2857(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH ALPHA-4/BETA-7 INTEGRIN;TISSUE SPECIFICITY;VARIANT PRO-GLU-SER-PRO-ASP-THR-THR-SER-GLN-GLU-PRO-PRO-ASP-THR-THR-SER-GLN-GLU-PRO-PRO-ASP-THR-THR-SER-253 INS
tissue: Lymph node.
3.

"Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene."
Leung E. , Berg R.W. , Langley R. , Greene J. , Raymond L.A. , Augustus M. , Ni J. , Carter K.C. , Spurr N. , Choo K.H.A. , Krissansen G.W.
Immunogenetics46:111-119(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2);VARIANT PRO-GLU-SER-PRO-ASP-THR-THR-SER-GLN-GLU-PRO-PRO-ASP-THR-THR-SER-GLN-GLU-PRO-PRO-ASP-THR-THR-SER-253 INS
tissue: Placenta.
4.

"Novel splicing variants of some human genes."
Wang P.Z. , Wang F. , Chang Q.S. , Wang X.
Submitted (2004-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
5.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANT PRO-GLU-SER-PRO-ASP-THR-THR-SER-GLN-GLU-PRO-PRO-ASP-THR-THR-SER-GLN-GLU-PRO-PRO-ASP-THR-THR-SER-253 INS
tissue: Brain.
8.

"The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition."
Tan K. , Casasnovas J.M. , Liu J.H. , Briskin M.J. , Springer T.A. , Wang J.H.
Structure6:793-801(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 23-231
9.

"A reassessment of the MAdCAM-1 structure and its role in integrin recognition."
Dando J. , Wilkinson K.W. , Ortlepp S. , King D.J. , Brady R.L.
Acta Crystallogr. D58:233-241(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 23-224

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