MASP1 ELISA Kit for Human(Homo sapiens) | EIAab.comMASP1 ELISA Kit for Human(Homo sapiens)

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MASP1 (Gene name),

Mannan-binding lectin serine protease 1 (Protein name ), MASP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

MASP1(CRARF;CRARF1;PRSS5);

Protein name:

Mannan-binding lectin serine protease 1;

Alternative:

Complement-activating component of Ra-reactive factor;Complement factor MASP-3;Mannose-binding protein-associated serine protease;Mannose-binding lectin-associated serine protease 1(MASP-1);Serine protease 5;Ra-reactive factor serine protease p100(RaRF);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with the oligomeric lectins MBL2, FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1.

Function:

Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

699

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

699:

VTLNRERGQW | YLVGTVSWGD | DCGKKDRYGV | YSYIHHNKDW | IQRVTGVRN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P48740

SMR:

P48740

Pfam:

PF00431

MIM:

257920

KEGG:

hsa:5648

UniGene:

Hs.89983

Uniprot:

P48740

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ELISA Kit for Human Mannan-binding lectin serine protease 1

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E1895h

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96T

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ELISA Kit for Human Mannan-binding lectin serine protease 1

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E1895m

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96T

ELISA Kit for Human Mannan-binding lectin serine protease 1

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E1895r

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96T

CLIA Kit for Human Mannan-binding lectin serine protease 1

Cat.:

U1895r

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Packing:

96T

CLIA Kit for Human Mannan-binding lectin serine protease 1

Cat.:

U1895m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Mannan-binding lectin serine protease 1

Cat.:

U1895h

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96T

Polyclonal Antibody for Human Mannan-binding lectin serine protease 1

Cat.:

P1895Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Mannan-binding lectin serine protease 1

Cat.:

P1895Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Mannan-binding lectin serine protease 1

Cat.:

P1895Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Mannan-binding lectin serine protease 1

Protein for Human Mannan-binding lectin serine protease 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum."
Takada F. , Takayama Y. , Hatsuse H. , Kawakami M.
Biochem. Biophys. Res. Commun.196:1003-1009(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Liver.
2.

"Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein."
Sato T. , Endo Y. , Matsushita M. , Fujita T.
Int. Immunol.6:665-669(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Fetal liver.
3.

"Exon structure of the gene encoding the human mannose-binding protein-associated serine protease light chain: comparison with complement C1r and C1s genes."
Endo Y. , Sato T. , Matsushita M. , Fujita T.
Int. Immunol.8:1355-1358(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Placenta.
4.

"Gene structure of the P100 serine-protease component of the human Ra-reactive factor."
Takayama Y. , Takada F. , Nowatari M. , Kawakami M. , Matsu-ura N.
Mol. Immunol.36:505-514(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway."
Dahl M.R. , Thiel S. , Matsushita M. , Fujita T. , Willis A.C. , Christensen T. , Vorup-Jensen T. , Jensenius J.C.
Immunity15:127-135(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PROTEIN SEQUENCE OF 450-474; 506-526; 539-555; 577-590; 613-621 AND 679-695 (ISOFORM 2);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Liver.
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4)
tissue: Placenta.
tissue: Teratocarcinoma.
tissue: Trachea.
7.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Fetal brain.
8.

"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
tissue: Fetal brain.
11.

"Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL."
Thielens N.M. , Cseh S. , Thiel S. , Vorup-Jensen T. , Rossi V. , Jensenius J.C. , Arlaud G.J.
J. Immunol.166:5068-5077(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-29 AND 449-458;SIGNAL SEQUENCE CLEAVAGE SITE;CLEAVAGE AT ARG-448;GLYCOSYLATION;HOMODIMERIZATION;INTERACTION WITH MBL2
12.

"Human serum mannose-binding lectin (MBL)-associated serine protease-1 (MASP-1): determination of levels in body fluids and identification of two forms in serum."
Terai I. , Kobayashi K. , Matsushita M. , Fujita T.
Clin. Exp. Immunol.110:317-323(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
13.

"A second serine protease associated with mannan-binding lectin that activates complement."
Thiel S. , Vorup-Jensen T. , Stover C.M. , Schwaeble W.J. , Laursen S.B. , Poulsen K. , Willis A.C. , Eggleton P. , Hansen S. , Holmskov U. , Reid K.B.M. , Jensenius J.C.
Nature386:506-510(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MBL2
tissue: Liver.
14.

"Complement-activating complex of ficolin and mannose-binding lectin-associated serine protease."
Matsushita M. , Endo Y. , Fujita T.
J. Immunol.164:2281-2284(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCN2
15.

"Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19."
Thiel S. , Petersen S.V. , Vorup-Jensen T. , Matsushita M. , Fujita T. , Stover C.M. , Schwaeble W.J. , Jensenius J.C.
J. Immunol.165:878-887(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MBL2
16.

"Proteolytic activities of two types of mannose-binding lectin-associated serine protease."
Matsushita M. , Thiel S. , Jensenius J.C. , Terai I. , Fujita T.
J. Immunol.165:2637-2642(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;INTERACTION WITH SERPING1
17.

"Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2."
Rossi V. , Cseh S. , Bally I. , Thielens N.M. , Jensenius J.C. , Arlaud G.J.
J. Biol. Chem.276:40880-40887(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION
18.

"Activation of the lectin complement pathway by H-ficolin (Hakata antigen)."
Matsushita M. , Kuraya M. , Hamasaki N. , Tsujimura M. , Shiraki H. , Fujita T.
J. Immunol.168:3502-3506(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCN3
19.

"Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2."
Cseh S. , Vera L. , Matsushita M. , Fujita T. , Arlaud G.J. , Thielens N.M.
J. Immunol.169:5735-5743(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCN2
20.

"Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments."
Ambrus G. , Gal P. , Kojima M. , Szilagyi K. , Balczer J. , Antal J. , Graf L. , Laich A. , Moffatt B.E. , Schwaeble W. , Sim R.B. , Zavodszky P.
J. Immunol.170:1374-1382(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
21.

"Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2."
Zundel S. , Cseh S. , Lacroix M. , Dahl M.R. , Matsushita M. , Andrieu J.-P. , Schwaeble W.J. , Jensenius J.C. , Fujita T. , Arlaud G.J. , Thielens N.M.
J. Immunol.172:4342-4350(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION (ISOFORM 2);MUTAGENESIS OF SER-646;AUTOCATALYTIC CLEAVAGE
22.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-49; ASN-178; ASN-385; ASN-407 (ISOFORM 1);GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-533 AND ASN-599 (ISOFORM 2)
tissue: Plasma.
23.

"Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5."
Cortesio C.L. , Jiang W.
Arch. Biochem. Biophys.449:164-170(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY (ISOFORM 2)
24.

"Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway."
Moeller-Kristensen M. , Thiel S. , Sjoeholm A. , Matsushita M. , Jensenius J.C.
Int. Immunol.19:141-149(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORMS 1 AND 2)
25.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-178 AND ASN-385
26.

"Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins."
Teillet F. , Gaboriaud C. , Lacroix M. , Martin L. , Arlaud G.J. , Thielens N.M.
J. Biol. Chem.283:25715-25724(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 20-295 IN COMPLEX WITH CALCIUM IONS;HOMODIMERIZATION;GLYCOSYLATION AT ASN-178;DISULFIDE BONDS;CALCIUM-BINDING SITES;INTERACTION WITH FCN2; FCN3 AND MBL2;MUTAGENESIS OF GLU-68; TYR-77; GLU-99; ASP-121; PHE-122; SER-123; GLU-125; HIS-237; GLU-239; TYR-244; GLU-262; SER-274; ASN-283 AND GLU-286
27.

"Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome."
Rooryck C. , Diaz-Font A. , Osborn D.P. , Chabchoub E. , Hernandez-Hernandez V. , Shamseldin H. , Kenny J. , Waters A. , Jenkins D. , Kaissi A.A. , Leal G.F. , Dallapiccola B. , Carnevale F. , Bitner-Glindzicz M. , Lees M. , Hennekam R. , Stanier P. , Burns A.J. , more...
Nat. Genet.43:197-203(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS 3MC1 TYR-497; ARG-630 AND GLU-666 (ISOFORM 2)

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