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Index > Protein center > MC4R(Gene name) > Human
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  • MC4R (Gene name),
  • Melanocortin receptor 4 (Protein name ),  MC4R_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    MC4R;
    Protein name:
    Melanocortin receptor 4(MC4-R);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ATRNL1 (By similarity). Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.
    Function:
    Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    332
    Sequence:
    50:
    MVNSTHRGMH | TSLHLWNRSS | YRLHSNASES | LGKGYSDGGC | YEQLFVSPEV | 
    100:
    FVTLGVISLL | ENILVIVAIA | KNKNLHSPMY | FFICSLAVAD | MLVSVSNGSE | 
    150:
    TIVITLLNST | DTDAQSFTVN | IDNVIDSVIC | SSLLASICSL | LSIAVDRYFT | 
    200:
    IFYALQYHNI | MTVKRVGIII | SCIWAACTVS | GILFIIYSDS | SAVIICLITM | 
    250:
    FFTMLALMAS | LYVHMFLMAR | LHIKRIAVLP | GTGAIRQGAN | MKGAITLTIL | 
    300:
    IGVFVVCWAP | FFLHLIFYIS | CPQNPYCVCF | MSHFNLYLIL | IMCNSIIDPL | 
    332:
    IYALRSQELR | KTFKEIICCY | PLGGLCDLSS | RY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    KEGG:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human MC4-R
    MSDS:
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    ELISA Kit for Human MC4-R
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    ELISA Kit for Human MC4-R
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    ELISA Kit for Human MC4-R
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    E11964m
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    ELISA Kit for Human MC4-R
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    E11964r
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    CLIA Kit for Human MC4-R
    MSDS:
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    CLIA Kit for Human MC4-R
    MSDS:
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    CLIA Kit for Human MC4-R
    Cat.:
    U11964h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human MC4-R
    Cat.:
    U11964m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human MC4-R
    Cat.:
    U11964r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human MC4-R
    Polyclonal Antibody for Human MC4-R
    Polyclonal Antibody for Human MC4-R
    Polyclonal Antibody for Human MC4-R
    Cat.:
    P11964Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MC4-R
    Monoclonal Antibody for Human MC4-R
    Monoclonal Antibody for Human MC4-R
    Monoclonal Antibody for Human MC4-R
    Monoclonal Antibody for Human MC4-R
    Monoclonal Antibody for Human MC4-R
    Protein for Human MC4-R
    Protein for Human MC4-R
    Protein for Human MC4-R
    Protein for Human MC4-R
    Protein for Human MC4-R

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    References
    1. 1.
      "Molecular cloning, expression, and gene localization of a fourth melanocortin receptor."
      Gantz I. , Miwa H. , Konda Y. , Shimoto Y. , Tashiro T. , Waston S.J. , Delvalle J.
      J. Biol. Chem.268:15174-15179(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ILE-103
    2. 2.
      "Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain."
      Mountjoy K.G. , Mortrud M.T. , Low M.J. , Simerly R.B. , Cone R.D.
      Mol. Endocrinol.8:1298-1308(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ILE-103
    3. 3.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A. , Aronstam R.S. , Sharma S.V.
      Submitted (2003-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Subthalamic nucleus.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MRAP AND MRAP2
    8. 8.
      "Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas."
      Perez-Oliva A.B. , Olivares C. , Jimenez-Cervantes C. , Garcia-Borron J.C.
      J. Biol. Chem.284:31714-31725(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MGRN1
    9. 9.
      "The melanocortin 4 receptor: oligomer formation, interaction sites and functional significance."
      Chapman K.L. , Findlay J.B.
      Biochim. Biophys. Acta1828:535-542(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERCHAIN DISULFIDE BOND;SUBUNIT
    10. 10.
      "Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans."
      Hinney A. , Schmidt A. , Nottebom K. , Heibult O. , Becker I. , Ziegler A. , Gerber G. , Sina M. , Gorg T. , Mayer H. , Siegfried W. , Fichter M. , Remschmidt H. , Hebebrand J.
      J. Clin. Endocrinol. Metab.84:1483-1486(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OBESITY ARG-30; VAL-37; LEU-78; TRP-165; SER-252 AND THR-317;VARIANTS MET-112 AND LEU-251
    11. 11.
      "A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity."
      Mergen M. , Mergen H. , Ozata M. , Oner R. , Oner C.
      J. Clin. Endocrinol. Metab.86:3448-3448(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OBESITY SER-274
    12. 12.
      "Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children."
      Dubern B. , Clement K. , Pelloux V. , Froguel P. , Girardet J.-P. , Guy-Grand B. , Tounian P.
      J. Pediatr.139:204-209(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OBESITY MET-50; CYS-58; SER-102 AND VAL-170;VARIANTS ILE-103 AND LEU-251
    13. 13.
      "Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms."
      Yeo G.S.H. , Lank E.J. , Farooqi I.S. , Keogh J. , Challis B.G. , O'Rahilly S.
      Hum. Mol. Genet.12:561-574(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OBESITY SER-62; ASP-97; PRO-106; LYS-125; GLN-165; THR-175; ILE-253; TYR-271 AND SER-316;CHARACTERIZATION OF VARIANTS OBESITY SER-62; ASP-97; PRO-106; LYS-125; GLN-165; THR-175; ILE-253; TYR-271 AND SER-316
    14. 14.
      "Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female."
      Donohoue P.A. , Tao Y.-X. , Collins M. , Yeo G.S.H. , O'Rahilly S. , Segaloff D.L.
      J. Clin. Endocrinol. Metab.88:5841-5845(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OBESITY 88-VAL--LEU-92 DEL;CHARACTERIZATION OF VARIANT OBESITY 88-VAL--LEU-92 DEL
    15. 15.
      "Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene."
      Farooqi I.S. , Keogh J.M. , Yeo G.S.H. , Lank E.J. , Cheetham T. , O'Rahilly S.
      N. Engl. J. Med.348:1085-1095(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OBESITY ALA-11; SER-62; ASP-97; LYS-125; GLN-165; THR-175; TYR-271; ARG-271 AND SER-316;VARIANTS ILE-103; MET-112 AND LEU-251;CHARACTERIZATION OF VARIANTS OBESITY ALA-11; SER-62; ASP-97; LYS-125; GLN-165; THR-175; TYR-271 AND SER-316;CHARACTERIZATION OF VARIANTS ILE-103; MET-112 AND LEU-251;FUNCTION
    16. 16.
      "Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese Finnish children and adults."
      Valli-Jaakola K. , Lipsanen-Nyman M. , Oksanen L. , Hollenberg A.N. , Kontula K. , Bjoerbaek C. , Schalin-Jaentti C.
      J. Clin. Endocrinol. Metab.89:940-945(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OBESITY LEU-127;VARIANTS ILE-103; MET-112; THR-226 AND LEU-251;CHARACTERIZATION OF VARIANT OBESITY LEU-127;CHARACTERIZATION OF VARIANTS MET-112 AND THR-226
    17. 17.
      "Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity."
      Larsen L.H. , Echwald S.M. , Soerensen T.I.A. , Andersen T. , Wulff B.S. , Pedersen O.
      J. Clin. Endocrinol. Metab.90:219-224(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OBESITY TYR-36; THR-102; GLN-165; THR-175; ASP-181; VAL-219 AND PHE-325;VARIANTS ILE-103; MET-112 AND LEU-251;CHARACTERIZATION OF VARIANTS OBESITY TYR-36; THR-102; GLN-165; ASP-181; VAL-219 AND PHE-325
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