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Index > Protein center > MCFD2(Gene name) > Human
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  • MCFD2 (Gene name),
  • Multiple coagulation factor deficiency protein 2 (Protein name ),  MCFD2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MCFD2(SDNSF);
    Protein name:
    Multiple coagulation factor deficiency protein 2;
    Alternative:
    Neural stem cell-derived neuronal survival protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts in a calcium-dependent manner with LMAN1.
    Function:
    The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
    Subcellular Location:
    Endoplasmic reticulum-Golgi intermediate compartment Endoplasmic reticulum Golgi apparatus
    Protein Attributes:
    Sequence length:
    146
    Sequence:
    50:
    MTMRSLLRTP | FLCGLLWAFC | APGARAEEPA | ASFSQPGSMG | LDKNTVHDQE | 
    100:
    HIMEHLEGVI | NKPEAEMSPQ | ELQLHYFKMH | DYDGNNLLDG | LELSTAITHV | 
    146:
    HKEEGSEQAP | LMSEDELINI | IDGVLRDDDK | NNDGYIDYAE | FAKSLQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    UniGene:
    Pfam:
    SMR:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Multiple coagulation factor deficiency protein 2
    Cat.:
    E15072h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Multiple coagulation factor deficiency protein 2
    Cat.:
    E15072m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Multiple coagulation factor deficiency protein 2
    MSDS:
    Please sign in first.
    CLIA Kit for Human Multiple coagulation factor deficiency protein 2
    MSDS:
    Please sign in first.
    CLIA Kit for Human Multiple coagulation factor deficiency protein 2
    Cat.:
    U15072h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Multiple coagulation factor deficiency protein 2
    Cat.:
    U15072m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Multiple coagulation factor deficiency protein 2
    Polyclonal Antibody for Human Multiple coagulation factor deficiency protein 2
    Polyclonal Antibody for Human Multiple coagulation factor deficiency protein 2
    Cat.:
    P15072Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Multiple coagulation factor deficiency protein 2
    Monoclonal Antibody for Human Multiple coagulation factor deficiency protein 2
    Monoclonal Antibody for Human Multiple coagulation factor deficiency protein 2
    Protein for Human Multiple coagulation factor deficiency protein 2
    Protein for Human Multiple coagulation factor deficiency protein 2
    Protein for Human Multiple coagulation factor deficiency protein 2
    Cat.:
    R15072h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%

    R&D Technical Data

    12% SDS-PAGE analysis

         12% SDS-PAGE analysis

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and characterization of SDNSF, a novel secretory molecule with neuronal survival effect, from adult rat hippocampal stem cells."
      Toda H. , Tashiro K. , Takahashi J. , Hashimoto N. , Nakano I. , Kobuke K. , Tsuji M. , Honjo T.
      Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Heart.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;INTERACTION WITH LMAN1;FUNCTION;VARIANTS F5F8D2 GLU-129 AND THR-136
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Synovium.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Melanoma.
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
      tissue: Skin.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "New insights into multiple coagulation factor deficiency from the solution structure of human MCFD2."
      Guy J.E. , Wigren E. , Svaerd M. , Haerd T. , Lindqvist Y.
      J. Mol. Biol.381:941-955(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 27-146;DOMAIN;CHARACTERIZATION OF VARIANTS F5F8D2 GLU-129 AND THR-136;CALCIUM-BINDING
    10. 10.
      "Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII."
      Wigren E. , Bourhis J.M. , Kursula I. , Guy J.E. , Lindqvist Y.
      FEBS Lett.584:878-882(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 58-146 IN COMPLEX WITH LMAN1;SUBUNIT
    11. 11.
      "Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency."
      Nishio M. , Kamiya Y. , Mizushima T. , Wakatsuki S. , Sasakawa H. , Yamamoto K. , Uchiyama S. , Noda M. , McKay A.R. , Fukui K. , Hauri H.P. , Kato K.
      Proc. Natl. Acad. Sci. U.S.A.107:4034-4039(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 27-146 IN COMPLEX WITH LMAN1;SUBUNIT;CALCIUM-BINDING SITES
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