CD46 ELISA Kit for Human(Homo sapiens) | EIAab.comCD46 ELISA Kit for Human(Homo sapiens)

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CD46 (Gene name),

Membrane cofactor protein (Protein name ), MCP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

CD46(MCP;MIC10);

Protein name:

Membrane cofactor protein;

Alternative:

Trophoblast leukocyte common antigen;TLX;

CD:

CD46;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with C3b and C4b. Binds to Measles virus H protein, to Human herpesvirus 6 GH protein and to human adenovirus B/D PIV/fiber protein, and acts as a receptor for these viruses. Binds to Streptococcus pyogenes M protein and to type IV pili from Neisseria, and may act as a receptor for these pathogenic bacteria.

Function:

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Subcellular Location:

Cytoplasmic vesicle secretory vesicle acrosome inner membrane Single-pass type I membrane protein Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.

Protein Attributes:

Sequence length:

392

Sequence:

50:

100:

150:

200:

250:

300:

350:

392:

VIAIVVGVAV | ICVVPYRYLQ | RRKKKGTYLT | DETHREVKFT | SL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P15529

String:

P15529

UniGene:

Hs.510402

KEGG:

hsa:4179

Pfam:

PF00084

MIM:

120920

Uniprot:

P15529

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ELISA Kit for Human Membrane cofactor protein

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E1275h

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ELISA Kit for Human Membrane cofactor protein

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E1275b

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ELISA Kit for Human Membrane cofactor protein

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E1275m

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ELISA Kit for Human Membrane cofactor protein

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E1275r

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ELISA Kit for Human Membrane cofactor protein

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E1275p

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96T

CLIA Kit for Human Membrane cofactor protein

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U1275h

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96T

CLIA Kit for Human Membrane cofactor protein

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U1275m

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96T

CLIA Kit for Human Membrane cofactor protein

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U1275r

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96T

CLIA Kit for Human Membrane cofactor protein

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U1275b

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CLIA Kit for Human Membrane cofactor protein

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U1275p

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Polyclonal Antibody for Human Membrane cofactor protein

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P1275Rb-m

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Polyclonal Antibody for Human Membrane cofactor protein

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P1275Rb-r

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Polyclonal Antibody for Human Membrane cofactor protein

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P1275Rb-h

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Monoclonal Antibody for Human Membrane cofactor protein

Protein for Human Membrane cofactor protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Citations

[1].

"Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism"

DA Lewis, S Suchindran, MG Beckman, et al.

From:Thrombosis Research

References

1.

"Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins."
Lublin D.M. , Liszewski M.K. , Post T.W. , Arce M.A. , le Beau M.M. , Rebentisch M.B. , Lemons R.S. , Seya T. , Atkinson J.P.
J. Exp. Med.168:181-194(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D);PROTEIN SEQUENCE OF 35-58;INTERACTION WITH C3B
2.

"Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation."
Purcell D.F. , Russell S.M. , Deacon N.J. , Brown M.A. , Hooker D.J. , McKenzie I.F.
Immunogenetics33:335-344(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C);ALTERNATIVE SPLICING
3.

"Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype."
Post T.W. , Liszewski M.K. , Adams E.M. , Tedja I. , Miller E.A. , Atkinson J.P.
J. Exp. Med.174:93-102(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D; E AND F)
4.

"Characterization of a cDNA clone coding for human testis membrane cofactor protein (MCP, CD46)."
Cervoni F. , Fenichel P. , Akhoundi C. , Hsi B.L. , Rossi B.
Mol. Reprod. Dev.34:107-113(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM F)
tissue: Testis.
5.

"Post-translational modification and intracellular localization of a splice product of CD46 cloned from human testis: role of the intracellular domains in O-glycosylation."
Hara T. , Suzuki Y. , Nakazawa T. , Nishimura H. , Nagasawa S. , Nishiguchi M. , Matsumoto M. , Hatanaka M. , Kitamura M. , Seya T.
Immunology93:546-555(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM N)
tissue: Testis.
6.

"Molecular cloning of human CD46 (membrane cofactor protein) CDS from cancer cell lines in a retroviral vector system."
Xue Z.T. , Widegren B. , Salford L.
Submitted (2006-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS D; F AND L)
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D)
tissue: Teratocarcinoma.
8.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS D AND E)
tissue: Fetal kidney.
tissue: Liver.
tissue: Salivary gland.
9.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B);VARIANT PHE-13
tissue: Liver.
10.

SeattleSNPs variation discovery resource
Submitted (2005-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASN-266; LEU-324; VAL-353 AND GLY-355
11.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
13.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D)
tissue: Testis.
14.

"Analysis of measles virus binding sites of the CD46 gene in patients with subacute sclerosing panencephalitis."
Kusuhara K. , Sasaki Y. , Nakao F. , Ihara K. , Hattori H. , Yamashita S. , Nihei K. , Koide N. , Aiba H. , Takeshita K. , Hara T.
J. Infect. Dis.181:1447-1449(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-158;VARIANTS PHE-13 AND GLN-59
15.

"Characterization of the promoter region of the membrane cofactor protein (CD46) gene of the human complement system and comparison to a membrane cofactor protein-like genetic element."
Cui W. , Hourcade D. , Post T.W. , Greenlund A.C. , Atkinson J.P. , Kumar V.
J. Immunol.151:4137-4146(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-34
16.

"Homology of an acrosome-reacted sperm-specific antigen to CD46."
Okabe M. , Ying X. , Nagira M. , Ikawa M. , Kohama Y. , Mimura T. , Tanaka K.
J. Pharmacobio-Dyn.15:455-459(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 35-60
tissue: Sperm.
17.

"Human non-lineage antigen, CD46 (HuLy-m5): purification and partial sequencing demonstrates structural homology with complement-regulating glycoproteins."
Purcell D.F. , Deacon N.J. , Andrew S.M. , McKenzie I.F.
Immunogenetics31:21-28(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 35-58
18.

"Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus."
Naniche D. , Varior-Krishnan G. , Cervoni F. , Wild T.F. , Rossi B. , Rabourdin-Combe C. , Gerlier D.
J. Virol.67:6025-6032(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 35-49;BINDING TO MEASLES VIRUS
19.

"Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity."
Adams E.M. , Brown M.C. , Nunge M. , Krych M. , Atkinson J.P.
J. Immunol.147:3005-3011(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C3B AND C4B
20.

"Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing."
Russell S.M. , Sparrow R.L. , McKenzie I.F.C. , Purcell D.F.J.
Eur. J. Immunol.22:1513-1518(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
21.

"The human CD46 molecule is a receptor for measles virus (Edmonston strain)."
Doerig R.E. , Marcil A. , Chopra A. , Richardson C.D.
Cell75:295-305(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BINDING TO MEASLES VIRUS
22.

"Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46)."
Manchester M. , Valsamakis A. , Kaufman R. , Liszewski M.K. , Alvarez J. , Atkinson J.P. , Lublin D.M. , Oldstone M.B.
Proc. Natl. Acad. Sci. U.S.A.92:2303-2307(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BINDING TO MEASLES VIRUS
23.

"Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus."
Okada N. , Liszewski M.K. , Atkinson J.P. , Caparon M.
Proc. Natl. Acad. Sci. U.S.A.92:2489-2493(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STREPTOCOCCUS PYOGENES M PROTEIN
24.

"The N-glycan of the SCR 2 region is essential for membrane cofactor protein (CD46) to function as a measles virus receptor."
Maisner A. , Alvarez J. , Liszewski M.K. , Atkinson D.J. , Atkinson J.P. , Herrler G.
J. Virol.70:4973-4977(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASN-83; ASN-114 AND ASN-273
25.

"Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria."
Kaellstroem H. , Liszewski M.K. , Atkinson J.P. , Jonsson A.-B.
Mol. Microbiol.25:639-647(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEISSERIA TYPE IV PILI
26.

"Membrane cofactor protein: importance of N- and O-glycosylation for complement regulatory function."
Liszewski M.K. , Leung M.K. , Atkinson J.P.
J. Immunol.161:3711-3718(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASN-83; ASN-114 AND ASN-273
27.

"CD46 is a cellular receptor for human herpesvirus 6."
Santoro F. , Kennedy P.E. , Locatelli G. , Malnati M.S. , Berger E.A. , Lusso P.
Cell99:817-827(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BINDING OF HUMAN HERPESVIRUS 6
28.

"Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation."
Wang G. , Liszewski M.K. , Chan A.C. , Atkinson J.P.
J. Immunol.164:1839-1846(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-384 (ISOFORM B); TYR-369 (ISOFORM D); TYR-354 (ISOFORM F); TYR-370 (ISOFORM H); TYR-355 (ISOFORM J); TYR-340 (ISOFORM L) AND TYR-321 (ISOFORM 3)
29.

"CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation."
Astier A. , Trescol-Biemont M.-C. , Azocar O. , Lamouille B. , Rabourdin-Combe C.
J. Immunol.164:6091-6095(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
30.

"SLAM (CDw150) is a cellular receptor for measles virus."
Tatsuo H. , Ono N. , Tanaka K. , Yanagi Y.
Nature406:893-897(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MEASLES VIRUS H PROTEIN
31.

"Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherence."
Kaellstroem H. , Blackmer Gill D. , Albiger B. , Liszewski M.K. , Atkinson J.P. , Jonsson A.-B.
Cell. Microbiol.3:133-143(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEISSERIA TYPE IV PILI;MUTAGENESIS OF ASN-83; ASN-114 AND ASN-273
32.

"Human Herpesvirus 6 and Measles Virus employ distinct CD46 domains for receptor function."
Greenstone H.L. , Santoro F. , Lusso P. , Berger E.A.
J. Biol. Chem.277:39112-39118(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BINDING OF HUMAN HERPESVIRUS 6
33.

"CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae."
Lee S.W. , Bonnah R.A. , Higashi D.L. , Atkinson J.P. , Milgram S.L. , So M.
J. Cell Biol.156:951-957(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION (ISOFORMS B/D/F/H/J/L/3)
34.

"Identification of the streptococcal M protein binding site on membrane cofactor protein (CD46)."
Giannakis E. , Jokiranta T.S. , Ormsby R.J. , Duthy T.G. , Male D.A. , Christiansen D. , Fischetti V.A. , Bagley C. , Loveland B.E. , Gordon D.L.
J. Immunol.168:4585-4592(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STREPTOCOCCUS PYOGENES M PROTEIN
35.

"Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa."
Riley R.C. , Kemper C. , Leung M. , Atkinson J.P.
Mol. Reprod. Dev.62:534-546(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;GLYCOSYLATION
36.

"Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46."
Santoro F. , Greenstone H.L. , Insinga A. , Liszewski M.K. , Atkinson J.P. , Lusso P. , Berger E.A.
J. Biol. Chem.278:25964-25969(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN HERPESVIRUS 6 GH PROTEIN
37.

"Down-regulation of CD46 by piliated Neisseria gonorrhoeae."
Gill D.B. , Koomey M. , Cannon J.G. , Atkinson J.P.
J. Exp. Med.198:1313-1322(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
38.

"Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46."
Mori Y. , Yang X. , Akkapaiboon P. , Okuno T. , Yamanishi K.
J. Virol.77:4992-4999(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN HERPESVIRUS 6 GH PROTEIN
39.

"Adenovirus type 11 uses CD46 as a cellular receptor."
Segerman A. , Atkinson J.P. , Marttila M. , Dennerquist V. , Wadell G. , Arnberg N.
J. Virol.77:9183-9191(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN ADENOVIRUS B TYPE 11 PIV/FIBER PROTEIN
40.

"Familial haemolytic uraemic syndrome and an MCP mutation."
Noris M. , Brioschi S. , Caprioli J. , Todeschini M. , Bresin E. , Porrati F. , Gamba S. , Remuzzi G.
Lancet362:1542-1547(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
41.

"Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype."
Kemper C. , Chan A.C. , Green J.M. , Brett K.A. , Murphy K.M. , Atkinson J.P.
Nature421:388-392(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
42.

"CD46 is a cellular receptor for group B adenoviruses."
Gaggar A. , Shayakhmetov D.M. , Lieber A.
Nat. Med.9:1408-1412(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN ADENOVIRUS B PIV/FIBER PROTEIN;IDENTIFICATION BY MASS SPECTROMETRY
43.

"Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form."
Hakulinen J. , Junnikkala S. , Sorsa T. , Meri S.
Eur. J. Immunol.34:2620-2629(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;SUBCELLULAR LOCATION
44.

"Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis."
Wu E. , Trauger S.A. , Pache L. , Mullen T.-M. , von Seggern D.J. , Siuzdak G. , Nemerow G.R.
J. Virol.78:3897-3905(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN ADENOVIRUS D TYPE 37 PIV/FIBER PROTEIN;IDENTIFICATION BY MASS SPECTROMETRY
45.

"The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3."
Sirena D. , Lilienfeld B. , Eisenhut M. , Kaelin S. , Boucke K. , Beerli R.R. , Vogt L. , Ruedl C. , Bachmann M.F. , Greber U.F. , Hemmi S.
J. Virol.78:4454-4462(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN ADENOVIRUS B TYPE 3 PIV/FIBER PROTEIN
46.

"Localization of regions in CD46 that interact with adenovirus."
Gaggar A. , Shayakhmetov D.M. , Liszewski M.K. , Atkinson J.P. , Lieber A.
J. Virol.79:7503-7513(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN ADENOVIRUS B TYPE 35 PIV/FIBER PROTEIN
47.

"CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7."
Marttila M. , Persson D. , Gustafsson D. , Liszewski M.K. , Atkinson J.P. , Wadell G. , Arnberg N.
J. Virol.79:14429-14436(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN ADENOVIRUS B PIV/FIBER PROTEIN
48.

"Crystal structure of two CD46 domains reveals an extended measles virus-binding surface."
Casasnovas J.M. , Larvie M. , Stehle T.
EMBO J.18:2911-2922(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 35-160
49.

"Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome."
Richards A. , Kemp E.J. , Liszewski M.K. , Goodship J.A. , Lampe A.K. , Decorte R. , Muesluemanoglu M.H. , Kavukcu S. , Filler G. , Pirson Y. , Wen L.S. , Atkinson J.P. , Goodship T.H.J.
Proc. Natl. Acad. Sci. U.S.A.100:12966-12971(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS AHUS2 PRO-240 AND 271-ASP-SER-272 DEL
50.

"Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome."
The international registry of recurrent and familial HUS/TTP , Caprioli J. , Noris M. , Brioschi S. , Pianetti G. , Castelletti F. , Bettinaglio P. , Mele C. , Bresin E. , Cassis L. , Gamba S. , Porrati F. , Bucchioni S. , Monteferrante G. , Fang C.J. , Liszewski M.K. , Kavanagh D. , Atkinson J.P. , more...
Blood108:1267-1279(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AHUS2 TYR-35
51.

"Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree."
Esparza-Gordillo J. , Jorge E.G. , Garrido C.A. , Carreras L. , Lopez-Trascasa M. , Sanchez-Corral P. , de Cordoba S.R.
Mol. Immunol.43:1769-1775(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AHUS2 SER-165
52.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] TYR-228 AND VAL-353
53.

"Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."
Maga T.K. , Nishimura C.J. , Weaver A.E. , Frees K.L. , Smith R.J.H.
Hum. Mutat.31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS2 CYS-216 AND ARG-231

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