MDM2 ELISA Kit for Human(Homo sapiens) | EIAab.comMDM2 ELISA Kit for Human(Homo sapiens)

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MDM2 (Gene name),

E3 ubiquitin-protein ligase Mdm2 (Protein name ), MDM2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MDM2;

Protein name:

E3 ubiquitin-protein ligase Mdm2;

Alternative:

Oncoprotein Mdm2;Double minute 2 protein(Hdm2);p53-binding protein Mdm2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds p53/TP53, TP73/p73, ARF/P14, PML, RBL5 and RP11, and specifically to RNA. Can interact with RB1, E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with p53/TP53 and WWOX. Interacts with CDKN2AIP, MTBP, RFWD3, TBRG1, USP7, PYHIN1, UBXN6, and RBBP6. Isoform Mdm2-F does not interact with p53/TP53. Interacts with and ubiquitinates HIV-1 Tat. Interacts with ARRB1 and ARRB2. Interacts (isoform 2) with PSMA3. Found in a trimeric complex with MDM2, MDM4 and UPB2. Interacts with USP2 (via N-terminus and C-terminus). Interacts with MDM4. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7. Interacts directly with DAXX and USP7. Interacts (via C-terminus) with RASSF1 isoform A (via N-terminus); the interaction is independent of TP53. Interacts with APEX1; leading to its ubiquitination and degradation. Interacts with RYBP; this inhibits ubiquitination of TP53. Identified in a complex with RYBP and p53/TP53. Also component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in regulating p53/TP53 stabilization and activity. Binds directly both p53/TP53 and TRIM28. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor responses with DNA damage. Interacts directly with both MDM2 and ERBB4 in the complex.

Function:

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.

Subcellular Location:

Nucleus nucleoplasm Cytoplasm Nucleus nucleolus Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.

Protein Attributes:

Sequence length:

491

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

491:

VHGKTGHLMA | CFTCAKKLKK | RNKPCPVCRQ | PIQMIVLTYF | P

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q00987

KEGG:

hsa:4193

MIM:

164785

UniGene:

Hs.484551

SMR:

Q00987

Pfam:

PF02201

Uniprot:

Q00987

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ELISA Kit for Human E3 ubiquitin-protein ligase Mdm2

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E12872m

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Packing:

96T

ELISA Kit for Human E3 ubiquitin-protein ligase Mdm2

Cat.:

E12872h

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Packing:

96T

ELISA Kit for Human E3 ubiquitin-protein ligase Mdm2

Cat.:

E12872d

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96T

CLIA Kit for Human E3 ubiquitin-protein ligase Mdm2

Cat.:

U12872m

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MSDS:

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Packing:

96T

CLIA Kit for Human E3 ubiquitin-protein ligase Mdm2

Cat.:

U12872h

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MSDS:

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Packing:

96T

CLIA Kit for Human E3 ubiquitin-protein ligase Mdm2

Cat.:

U12872d

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96T

Polyclonal Antibody for Human E3 ubiquitin-protein ligase Mdm2

Cat.:

P12872Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human E3 ubiquitin-protein ligase Mdm2

Cat.:

P12872Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human E3 ubiquitin-protein ligase Mdm2

Protein for Human E3 ubiquitin-protein ligase Mdm2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Amplification of a gene encoding a p53-associated protein in human sarcomas."
Oliner J.D. , Kinzler K.W. , Meltzer P.S. , George D.L. , Vogelstein B.
Nature358:80-83(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MDM2)
tissue: Colon.
2.

"Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer."
Sigalas I. , Calvert A.H. , Anderson J.J. , Neal D.E. , Lunec J.
Nat. Med.2:912-917(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MDM2-A; MDM2-B; MDM2-C; MDM2-D AND MDM2-E)
tissue: Ovarian carcinoma.
3.

"A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein."
Veldhoen N. , Metcalfe S. , Milner J.
Oncogene18:7026-7033(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MDM2-ALPHA)
4.

"Analysis of the molecular species generated by MDM2 gene amplification in liposarcomas."
Tamborini E. , Della Torre G. , Lavarino C. , Azzarelli A. , Carpinelli P. , Pierotti M.A. , Pilotti S.
Int. J. Cancer92:790-796(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MDM2-F AND MDM2-G);INTERACTION WITH TP53
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MDM2)
tissue: Tongue.
6.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MDM2)
7.

NIEHS SNPs program
Submitted (2002-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 11)
tissue: Rhabdomyosarcoma.
10.

"A functional p53-responsive intronic promoter is contained within the human mdm2 gene."
Zauberman A. , Flusberg D. , Haupt Y. , Barak Y. , Oren M.
Nucleic Acids Res.23:2584-2592(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24
11.

"Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein."
Landers J.E. , Cassel S.L. , George D.L.
Cancer Res.57:3562-3568(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9
12.

"Genomic organisation of the human MDM2 oncogene and relationship to its alternatively spliced mRNAs."
Liang H. , Atkins H. , Abdel-Fattah R. , Jones S.N. , Lunec J.
Gene338:217-223(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-491 (ISOFORM MDM2-A1)
13.

"A MboII polymorphism in exon 11 of the human MDM2 gene occurring in normal blood donors and in soft tissue sarcoma patients: an indication for an increased cancer susceptibility?"
Taubert H. , Kappler M. , Meye A. , Bartel F. , Schlott T. , Lautenschlaeger C. , Bache M. , Schmidt H. , Wuerl P.
Mutat. Res.456:39-44(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 301-481
14.

"Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes."
Olson D.C. , Marechal V. , Momand J. , Chen J. , Romocki C. , Levine A.J.
Oncogene8:2353-2360(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH TP53
15.

"Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53."
Honda R. , Tanaka H. , Yasuda H.
FEBS Lett.420:25-27(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-464
16.

"Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein."
Sharp D.A. , Kratowicz S.A. , Sank M.J. , George D.L.
J. Biol. Chem.274:38189-38196(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-441 AND CYS-478
17.

"Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage."
Khosravi R. , Maya R. , Gottlieb T. , Oren M. , Shiloh Y. , Shkedy D.
Proc. Natl. Acad. Sci. U.S.A.96:14973-14977(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ATM
18.

"Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53."
Fang S. , Jensen J.P. , Ludwig R.L. , Vousden K.H. , Weissman A.M.
J. Biol. Chem.275:8945-8951(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
19.

"Identification of a cryptic nucleolar-localization signal in MDM2."
Lohrum M.A.E. , Ashcroft M. , Kubbutat M.H.G. , Vousden K.H.
Nat. Cell Biol.2:179-181(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOLAR LOCALIZATION SIGNAL
20.

"Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase."
Honda R. , Yasuda H.
Oncogene19:1473-1476(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-449
21.

"Hypophosphorylation of Mdm2 augments p53 stability."
Blattner C. , Hay T. , Meek D.W. , Lane D.P.
Mol. Cell. Biol.22:6170-6182(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-240; SER-242; SER-246; SER-260 AND SER-262
22.

"A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter."
Bres V. , Kiernan R.E. , Linares L.K. , Chable-Bessia C. , Plechakova O. , Treand C. , Emiliani S. , Peloponese J.-M. , Jeang K.-T. , Coux O. , Scheffner M. , Benkirane M.
Nat. Cell Biol.5:754-761(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 TAT
23.

"Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor."
Girnita L. , Girnita A. , Larsson O.
Proc. Natl. Acad. Sci. U.S.A.100:8247-8252(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF IGF1R;INTERACTION WITH IGF1R
24.

"Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells."
Nishizaki M. , Sasaki J. , Fang B. , Atkinson E.N. , Minna J.D. , Roth J.A. , Ji L.
Cancer Res.64:5745-5752(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FHIT
25.

"A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans."
Bond G.L. , Hu W. , Bond E.E. , Robins H. , Lutzker S.G. , Arva N.C. , Bargonetti J. , Bartel F. , Taubert H. , Wuerl P. , Onel K. , Yip L. , Hwang S.J. , Strong L.C. , Lozano G. , Levine A.J.
Cell119:591-602(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ACCELERATED TUMOR FORMATION
26.

"Negative regulation of p53 functions by Daxx and the involvement of MDM2."
Zhao L.Y. , Liu J. , Sidhu G.S. , Niu Y. , Liu Y. , Wang R. , Liao D.
J. Biol. Chem.279:50566-50579(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAXX
27.

"A dynamic role of HAUSP in the p53-Mdm2 pathway."
Li M. , Brooks C.L. , Kon N. , Gu W.
Mol. Cell13:879-886(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH USP7;DEUBIQUITINATION BY USP7
28.

"PML regulates p53 stability by sequestering Mdm2 to the nucleolus."
Bernardi R. , Scaglioni P.P. , Bergmann S. , Horn H.F. , Vousden K.H. , Pandolfi P.P.
Nat. Cell Biol.6:665-672(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PML AND RPL11;SUBCELLULAR LOCATION
29.

"{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase."
Girnita L. , Shenoy S.K. , Sehat B. , Vasilcanu R. , Girnita A. , Lefkowitz R.J. , Larsson O.
J. Biol. Chem.280:24412-24419(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB1 AND ARRB2
30.

"WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53."
Chang N.-S. , Doherty J. , Ensign A. , Schultz L. , Hsu L.-J. , Hong Q.
J. Biol. Chem.280:43100-43108(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WWOX AND TP53
31.

"MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein."
Sdek P. , Ying H. , Chang D.L. , Qiu W. , Zheng H. , Touitou R. , Allday M.J. , Xiao Z.X.
Mol. Cell20:699-708(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PSMA3
32.

"Regulation of p53 and MDM2 activity by MTBP."
Brady M. , Vlatkovic N. , Boyd M.T.
Mol. Cell. Biol.25:545-553(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MTBP;MUTAGENESIS OF CYS-464
33.

"AAA ATPase p97 and adaptor UBXD1 suppress MDM2 ubiquitination and degradation and promote constitutive p53 turnover."
Zweitzig D.R. , Shcherbik N. , Haines D.S.
Mol. Biol. Cell19:5029-5029(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBXN6
34.

"ATM activates p53 by regulating MDM2 oligomerization and E3 processivity."
Cheng Q. , Chen L. , Li Z. , Lane W.S. , Chen J.
EMBO J.28:3857-3867(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-386; SER-395; SER-407; THR-419; SER-425 AND SER-429
35.

"RYBP stabilizes p53 by modulating MDM2."
Chen D. , Zhang J. , Li M. , Rayburn E.R. , Wang H. , Zhang R.
EMBO Rep.10:166-172(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RYBP;IDENTIFICATION IN A COMPLEX WITH RYBP AND TP53
36.

"MTA1 coregulator regulates p53 stability and function."
Li D.Q. , Divijendra Natha Reddy S. , Pakala S.B. , Wu X. , Zhang Y. , Rayala S.K. , Kumar R.
J. Biol. Chem.284:34545-34552(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MTA1
37.

"Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation."
Amato R. , D'Antona L. , Porciatti G. , Agosti V. , Menniti M. , Rinaldo C. , Costa N. , Bellacchio E. , Mattarocci S. , Fuiano G. , Soddu S. , Paggi M.G. , Lang F. , Perrotti N.
J. Mol. Med.87:1221-1239(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-166 BY SGK1
38.

"Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway."
Lee H.R. , Toth Z. , Shin Y.C. , Lee J.S. , Chang H. , Gu W. , Oh T.K. , Kim M.H. , Jung J.U.
J. Virol.83:6739-6747(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-8 PROTEIN VIRF4
39.

"Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway."
Busso C.S. , Iwakuma T. , Izumi T.
Oncogene28:1616-1625(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH APEX1;MUTAGENESIS OF CYS-464
40.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION
41.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
42.

"p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma."
Lim S.O. , Kim H. , Jung G.
FEBS Lett.584:2231-2236(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SNAI1
43.

"ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage."
Taira N. , Yamamoto H. , Yamaguchi T. , Miki Y. , Yoshida K.
J. Biol. Chem.285:4909-4919(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DYRK2 UBIQUITINATION;INTERACTION WITH DYRK2
44.

"Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."
Gilmore-Hebert M. , Ramabhadran R. , Stern D.F.
Mol. Cancer Res.8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM28 IN THE TRIM28/KAP1-ERBB4-MDM2 COMPLEX AND WITH TP53 IN THE TRIM28/KAP1-MDM2-P53/TP53 COMPLEX;FUNCTION;SUBCELLULAR LOCATION
45.

"RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage."
Fu X. , Yucer N. , Liu S. , Li M. , Yi P. , Mu J.J. , Yang T. , Chu J. , Jung S.Y. , O'Malley B.W. , Gu W. , Qin J. , Wang Y.
Proc. Natl. Acad. Sci. U.S.A.107:4579-4584(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TP53 AND RFWD3;MUTAGENESIS OF CYS-464
46.

"MdmX is a substrate for the deubiquitinating enzyme USP2a."
Allende-Vega N. , Sparks A. , Lane D.P. , Saville M.K.
Oncogene29:432-441(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP2 AND MDM4
47.

"Notch1 binds and induces degradation of Snail in hepatocellular carcinoma."
Lim S.O. , Kim H.S. , Quan X. , Ahn S.M. , Kim H. , Hsieh D. , Seong J.K. , Jung G.
BMC Biol.9:83-83(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SNAI1 AND NOTCH1
48.

"Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2."
Joo H.M. , Kim J.Y. , Jeong J.B. , Seong K.M. , Nam S.Y. , Yang K.H. , Kim C.S. , Kim H.S. , Jeong M. , An S. , Jin Y.W.
Eur. J. Cell Biol.90:420-431(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM13;UBIQUITINATION
49.

"Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2."
Ding Y. , Lee J.-F. , Lu H. , Lee M.-H. , Yan D.-H.
Mol. Cell. Biol.26:1979-1996(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH PYHIN1;MUTAGENESIS OF CYS-464
50.

"Critical role for Daxx in regulating Mdm2."
Tang J. , Qu L.K. , Zhang J. , Wang W. , Michaelson J.S. , Degenhardt Y.Y. , El-Deiry W.S. , Yang X.
Nat. Cell Biol.8:855-862(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH DAXX AND USP7;INTERACTION WITH DAXX;SUBCELLULAR LOCATION
51.

"CARF binds to three members (ARF, p53, and HDM2) of the p53 tumor-suppressor pathway."
Kamrul H.M. , Wadhwa R. , Kaul S.C.
Ann. N. Y. Acad. Sci.1100:312-315(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDKN2AIP
52.

"The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2."
Stevenson L.F. , Sparks A. , Allende-Vega N. , Xirodimas D.P. , Lane D.P. , Saville M.K.
EMBO J.26:976-986(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH USP2;UBIQUITINATION;DEUBIQUITINATION BY USP2
53.

"The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes."
Ruijs M.W. , Schmidt M.K. , Nevanlinna H. , Tommiska J. , Aittomaki K. , Pruntel R. , Verhoef S. , Van't Veer L.J.
Eur. J. Hum. Genet.15:110-114(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ACCELERATED TUMOR FORMATION AND LI-FRAUMENI SYNDROME
54.

"A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability."
Tompkins V.S. , Hagen J. , Frazier A.A. , Lushnikova T. , Fitzgerald M.P. , di Tommaso A.D. , Ladeveze V. , Domann F.E. , Eischen C.M. , Quelle D.E.
J. Biol. Chem.282:1322-1333(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBRG1
55.

"PACT is a negative regulator of p53 and essential for cell growth and embryonic development."
Li L. , Deng B. , Xing G. , Teng Y. , Tian C. , Cheng X. , Yin X. , Yang J. , Gao X. , Zhu Y. , Sun Q. , Zhang L. , Yang X. , He F.
Proc. Natl. Acad. Sci. U.S.A.104:7951-7956(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBBP6
56.

"CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2."
Yang W. , Dicker D.T. , Chen J. , El-Deiry W.S.
Cell Cycle7:670-682(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RFFL AND RNF34;AUTOUBIQUITINATION
57.

"The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex."
Song M.S. , Song S.J. , Kim S.Y. , Oh H.J. , Lim D.S.
EMBO J.27:1863-1874(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH DAXX; RASSF1 AND USP7;INTERACTION WITH RASSF1; USP7 AND DAXX;SUBCELLULAR LOCATION
58.

"BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction."
Yang Q. , Liao L. , Deng X. , Chen R. , Gray N.S. , Yates J.R. III , Lee J.D.
Oncogene32:3156-3164(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH PML
59.

"Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain."
Kussie P.H. , Gorina S. , Marechal V. , Elenbaas B. , Moreau J. , Levine A.J. , Pavletich N.P.
Science274:948-953(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 25-109 IN COMPLEX WITH P53
60.

"Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway."
Hu M. , Gu L. , Li M. , Jeffrey P.D. , Gu W. , Shi Y.
PLoS Biol.4:228-239(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 224-232 IN COMPLEX WITH USP7;INTERACTION WITH USP7
61.

"Molecular recognition of p53 and MDM2 by USP7/HAUSP."
Sheng Y. , Saridakis V. , Sarkari F. , Duan S. , Wu T. , Arrowsmith C.H. , Frappier L.
Nat. Struct. Mol. Biol.13:285-291(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 145-150 IN COMPLEX WITH USP7;INTERACTION WITH USP7

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