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Index > Protein center > MTR(Gene name) > Human
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  • MTR (Gene name),
  • Methionine synthase (Protein name ),  METH_HUMAN from NCBI database.
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  • Gene name:
    MTR;
    Protein name:
    Methionine synthase;
    Alternative:
    Vitamin-B12 dependent methionine synthase(MS);5-methyltetrahydrofolate--homocysteine methyltransferase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    1265
    Sequence:
    50:
    MSPALQDLSQ | PEGLKKTLRD | EINAILQKRI | MVLDGGMGTM | IQREKLNEEH | 
    100:
    FRGQEFKDHA | RPLKGNNDIL | SITQPDVIYQ | IHKEYLLAGA | DIIETNTFSS | 
    150:
    TSIAQADYGL | EHLAYRMNMC | SAGVARKAAE | EVTLQTGIKR | FVAGALGPTN | 
    200:
    KTLSVSPSVE | RPDYRNITFD | ELVEAYQEQA | KGLLDGGVDI | LLIETIFDTA | 
    250:
    NAKAALFALQ | NLFEEKYAPR | PIFISGTIVD | KSGRTLSGQT | GEGFVISVSH | 
    300:
    GEPLCIGLNC | ALGAAEMRPF | IEIIGKCTTA | YVLCYPNAGL | PNTFGDYDET | 
    350:
    PSMMAKHLKD | FAMDGLVNIV | GGCCGSTPDH | IREIAEAVKN | CKPRVPPATA | 
    400:
    FEGHMLLSGL | EPFRIGPYTN | FVNIGERCNV | AGSRKFAKLI | MAGNYEEALC | 
    450:
    VAKVQVEMGA | QVLDVNMDDG | MLDGPSAMTR | FCNLIASEPD | IAKVPLCIDS | 
    500:
    SNFAVIEAGL | KCCQGKCIVN | SISLKEGEDD | FLEKARKIKK | YGAAMVVMAF | 
    550:
    DEEGQATETD | TKIRVCTRAY | HLLVKKLGFN | PNDIIFDPNI | LTIGTGMEEH | 
    600:
    NLYAINFIHA | TKVIKETLPG | ARISGGLSNL | SFSFRGMEAI | REAMHGVFLY | 
    650:
    HAIKSGMDMG | IVNAGNLPVY | DDIHKELLQL | CEDLIWNKDP | EATEKLLRYA | 
    700:
    QTQGTGGKKV | IQTDEWRNGP | VEERLEYALV | KGIEKHIIED | TEEARLNQKK | 
    750:
    YPRPLNIIEG | PLMNGMKIVG | DLFGAGKMFL | PQVIKSARVM | KKAVGHLIPF | 
    800:
    MEKEREETRV | LNGTVEEEDP | YQGTIVLATV | KGDVHDIGKN | IVGVVLGCNN | 
    850:
    FRVIDLGVMT | PCDKILKAAL | DHKADIIGLS | GLITPSLDEM | IFVAKEMERL | 
    900:
    AIRIPLLIGG | ATTSKTHTAV | KIAPRYSAPV | IHVLDASKSV | VVCSQLLDEN | 
    950:
    LKDEYFEEIM | EEYEDIRQDH | YESLKERRYL | PLSQARKSGF | QMDWLSEPHP | 
    1000:
    VKPTFIGTQV | FEDYDLQKLV | DYIDWKPFFD | VWQLRGKYPN | RGFPKIFNDK | 
    1050:
    TVGGEARKVY | DDAHNMLNTL | ISQKKLRARG | VVGFWPAQSI | QDDIHLYAEA | 
    1100:
    AVPQAAEPIA | TFYGLRQQAE | KDSASTEPYY | CLSDFIAPLH | SGIRDYLGLF | 
    1150:
    AVACFGVEEL | SKAYEDDGDD | YSSIMVKALG | DRLAEAFAEE | LHERVRRELW | 
    1200:
    AYCGSEQLDV | ADLRRLRYKG | IRPAPGYPSQ | PDHTEKLTMW | RLADIEQSTG | 
    1250:
    IRLTESLAMA | PASAVSGLYF | SNLKSKYFAV | GKISKDQVED | YALRKNISVA | 
    1265:
    EVEKWLGPIL | GYDTD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    KEGG:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Methionine synthase
    Cat.:
    E14988h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Methionine synthase
    MSDS:
    Please sign in first.
    ELISA Kit for Human Methionine synthase
    MSDS:
    Please sign in first.
    ELISA Kit for Human Methionine synthase
    Cat.:
    E14988m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Methionine synthase
    Cat.:
    U14988m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Methionine synthase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Methionine synthase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Methionine synthase
    Cat.:
    U14988h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Methionine synthase
    Polyclonal Antibody for Human Methionine synthase
    Polyclonal Antibody for Human Methionine synthase
    Polyclonal Antibody for Human Methionine synthase
    Monoclonal Antibody for Human Methionine synthase
    Monoclonal Antibody for Human Methionine synthase
    Monoclonal Antibody for Human Methionine synthase
    Monoclonal Antibody for Human Methionine synthase
    Protein for Human Methionine synthase
    Protein for Human Methionine synthase
    Protein for Human Methionine synthase
    Protein for Human Methionine synthase

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders."
      Leclerc D. , Campeau E. , Goyette P. , Adjalla C.E. , Christensen B. , Ross M. , Eydoux P. , Rosenblatt D.S. , Rozen R. , Gravel R.A.
      Hum. Mol. Genet.5:1867-1874(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS HMAG ILE-881 DEL AND ASP-920
      tissue: Fibroblast.
    2. 2.
      "Cloning, mapping and RNA analysis of the human methionine synthase gene."
      Li Y.N. , Gulati S. , Baker P.J. , Brody L.C. , Banerjee R. , Kruger W.D.
      Hum. Mol. Genet.5:1851-1858(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    3. 3.
      "Human methionine synthase. cDNA cloning, gene localization, and expression."
      Chen L.H. , Liu M.-L. , Hwang H.-Y. , Chen L.-S. , Korenberg J. , Shane B.
      J. Biol. Chem.272:3628-3634(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS TYR-255 AND GLY-919
      tissue: Fetal liver.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT GLY-919
      tissue: Testis.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "Defects in human methionine synthase in cblG patients."
      Gulati S. , Baker P.J. , Li Y.N. , Fowler B. , Kruger W.D. , Brody L.C. , Banerjee R.
      Hum. Mol. Genet.5:1859-1865(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HMAG ILE-881 DEL AND LEU-1173;VARIANT LYS-61
    9. 9.
      "Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida."
      Doolin M.-T. , Barbaux S. , McDonnell M. , Hoess K. , Whitehead A.S. , Mitchell L.E.
      Am. J. Hum. Genet.71:1222-1226(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT GLY-919 WITH SUSCEPTIBILITY TO FS-NTD
    10. 10.
      "Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association."
      O'Leary V.B. , Mills J.L. , Pangilinan F. , Kirke P.N. , Cox C. , Conley M. , Weiler A. , Peng K. , Shane B. , Scott J.M. , Parle-McDermott A. , Molloy A.M. , Brody L.C.
      Mol. Genet. Metab.85:220-227(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NO ASSOCIATION OF VARIANT GLY-919 WITH SUSCEPTIBILITY TO FS-NTD
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