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Index > Protein center > MAP2K5(Gene name) > Human
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  • MAP2K5 (Gene name),
  • Dual specificity mitogen-activated protein kinase kinase 5 (Protein name ),  MP2K5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MAP2K5(MEK5;MKK5;PRKMK5);
    Protein name:
    Dual specificity mitogen-activated protein kinase kinase 5(MAP kinase kinase 5;MAPKK 5);
    Alternative:
    MAPK/ERK kinase 5(MEK 5);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with Yersinia yopJ.
    Function:
    Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    448
    Sequence:
    50:
    MLWLALGPFP | AMENQVLVIR | IKIPNSGAVD | WTVHSGPQLL | FRDVLDVIGQ | 
    100:
    VLPEATTTAF | EYEDEDGDRI | TVRSDEEMKA | MLSYYYSTVM | EQQVNGQLIE | 
    150:
    PLQIFPRACK | PPGERNIHGL | KVNTRAGPSQ | HSSPAVSDSL | PSNSLKKSSA | 
    200:
    ELKKILANGQ | MNEQDIRYRD | TLGHGNGGTV | YKAYHVPSGK | ILAVKVILLD | 
    250:
    ITLELQKQIM | SELEILYKCD | SSYIIGFYGA | FFVENRISIC | TEFMDGGSLD | 
    300:
    VYRKMPEHVL | GRIAVAVVKG | LTYLWSLKIL | HRDVKPSNML | VNTRGQVKLC | 
    350:
    DFGVSTQLVN | SIAKTYVGTN | AYMAPERISG | EQYGIHSDVW | SLGISFMELA | 
    400:
    LGRFPYPQIQ | KNQGSLMPLQ | LLQCIVDEDS | PVLPVGEFSE | PFVHFITQCM | 
    448:
    RKQPKERPAP | EELMGHPFIV | QFNDGNAAVV | SMWVCRALEE | RRSQQGPP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    SMR:
    String:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human MAP kinase kinase 5
    Cat.:
    E10343h
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    Packing:
    96T
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    ELISA Kit for Human MAP kinase kinase 5
    Cat.:
    E10343m
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    Packing:
    96T
    ELISA Kit for Human MAP kinase kinase 5
    Cat.:
    E10343r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human MAP kinase kinase 5
    Cat.:
    U10343h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human MAP kinase kinase 5
    Cat.:
    U10343r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MAP kinase kinase 5
    Cat.:
    U10343m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human MAP kinase kinase 5
    Polyclonal Antibody for Human MAP kinase kinase 5
    Polyclonal Antibody for Human MAP kinase kinase 5
    Cat.:
    P10343Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human MAP kinase kinase 5
    Monoclonal Antibody for Human MAP kinase kinase 5
    Monoclonal Antibody for Human MAP kinase kinase 5
    Protein for Human MAP kinase kinase 5
    Protein for Human MAP kinase kinase 5
    Protein for Human MAP kinase kinase 5

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Components of a new human protein kinase signal transduction pathway."
      Zhou G. , Bao Z.Q. , Dixon J.E.
      J. Biol. Chem.270:12665-12669(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A);FUNCTION;INTERACTION WITH ERK5 AND MAPK7;MUTAGENESIS OF LYS-195; SER-311 AND THR-315;PHOSPHORYLATION AT SER-311 AND THR-315
      tissue: Fetal brain.
    2. 2.
      "BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C."
      Kato Y. , Kravchenko V.V. , Tapping R.I. , Han J. , Ulevitch R.J. , Lee J.-D.
      EMBO J.16:7054-7066(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C);FUNCTION
      tissue: Placenta.
    3. 3.
      Lee J.D.
      Submitted (2007-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO C-TERMINUS OF ISOFORM C
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Cerebellum.
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
      tissue: Brain.
    8. 9.
      "Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation."
      Mukherjee S. , Keitany G. , Li Y. , Wang Y. , Ball H.L. , Goldsmith E.J. , Orth K.
      Science312:1211-1214(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH YOPJ;ACETYLATION
    9. 10.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 13.
      "Crystal structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-Phox) with human mitogen activated protein kinase kinase kinase 3 (MAP3K2B-Phox)."
      Structural genomics consortium (SGC)
      Submitted (2006-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 4-108 IN COMPLEX WITH MAP3K2
    13. 14.
      "Crystal structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-Phox) with human mitogen activated protein kinase kinase kinase 3 (MAP3K3B-Phox)."
      Structural genomics consortium (SGC)
      Submitted (2006-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 4-108 IN COMPLEX WITH MAP3K3
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