MRC2 ELISA Kit for Human(Homo sapiens) | EIAab.comMRC2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MRC2(Gene name) > Human

MRC2 (Gene name),

C-type mannose receptor 2 (Protein name ), MRC2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MRC2(CLEC13E;ENDO180;KIAA0709;UPARAP);

Protein name:

C-type mannose receptor 2;

Alternative:

Endocytic receptor 180;C-type lectin domain family 13 member E;Urokinase-type plasminogen activator receptor-associated protein(UPAR-associated protein;Urokinase receptor-associated protein);Macrophage mannose receptor 2;

CD:

CD280;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.

Function:

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1479

Sequence:

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1400:

1450:

1479:

RYSRSSSSPT | EATEKNILVS | DMEMNEQQE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000307513

SMR:

Q9UBG0

UniGene:

Hs.7835

String:

Q9UBG0

KEGG:

hsa:9902

MIM:

612264

Pfam:

PF00040

Uniprot:

Q9UBG0

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ELISA Kit for Human C-type mannose receptor 2

Cat.:

E2105h

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96T

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ELISA Kit for Human C-type mannose receptor 2

Cat.:

E2105m

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96T

ELISA Kit for Human C-type mannose receptor 2

Cat.:

E2105r

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96T

CLIA Kit for Human C-type mannose receptor 2

Cat.:

U2105r

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96T

CLIA Kit for Human C-type mannose receptor 2

Cat.:

U2105m

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MSDS:

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Packing:

96T

CLIA Kit for Human C-type mannose receptor 2

Cat.:

U2105h

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96T

Polyclonal Antibody for Human C-type mannose receptor 2

Cat.:

P2105Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human C-type mannose receptor 2

Cat.:

P2105Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human C-type mannose receptor 2

Cat.:

P2105Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human C-type mannose receptor 2

Protein for Human C-type mannose receptor 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A urokinase receptor-associated protein with specific collagen binding properties."
Behrendt N. , Jensen O.N. , Engelholm L.H. , Moertz E. , Mann M. , Danoe K.
J. Biol. Chem.275:1993-2002(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 350-360;IDENTIFICATION BY MASS SPECTROMETRY;SUBUNIT;VARIANT HIS-1156
2.

"Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor."
Sheikh H. , Yarwood H. , Ashworth A. , Isacke C.M.
J. Cell Sci.113:1021-1032(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;PHOSPHORYLATION;GLYCOSYLATION;TISSUE SPECIFICITY;VARIANTS ILE-43 AND HIS-1156
3.

"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Ishikawa K. , Nagase T. , Suyama M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.5:169-176(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT HIS-1156
tissue: Brain.
4.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT HIS-1156
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT HIS-1156
7.

"Characterization of a novel member of the macrophage mannose receptor type C lectin family."
Wu K. , Yuan J. , Lasky L.A.
J. Biol. Chem.271:21323-21330(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
8.

"The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family."
Howard M.J. , Isacke C.M.
J. Biol. Chem.277:32320-32331(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-1452; GLU-1464 AND 1468-LEU-VAL-1469
9.

"Characterization of sugar binding by the mannose receptor family member, Endo180."
East L. , Rushton S. , Taylor M.E. , Isacke C.M.
J. Biol. Chem.277:50469-50475(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN;MUTAGENESIS OF ASN-472
10.

"Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor."
Wienke D. , MacFadyen J.R. , Isacke C.M.
Mol. Biol. Cell14:3592-3604(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN
11.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69
tissue: Liver.
12.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-69
13.

"In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."
Blomster H.A. , Imanishi S.Y. , Siimes J. , Kastu J. , Morrice N.A. , Eriksson J.E. , Sistonen L.
J. Biol. Chem.285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-1142
tissue: Cervix carcinoma.

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