Protein name:
Mucin-4 (MUC-4) ;
Alternative:
Pancreatic adenocarcinoma mucin ;Ascites sialoglycoprotein (ASGP) ;Tracheobronchial mucin ;Testis mucin ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3.
Function:
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.
Subcellular Location:
Isoform 17
Cell membrane
Single-pass membrane protein
Protein Attributes:
50:
MKGARWRRVP | WVSLSCLCLC | LLPHVVPGTT | EDTLITGSKT | AAPVTSTGST |
100:
TATLEGQSTA | ASSRTSNQDI | SASSQNHQTK | STETTSKAQT | DTLTQMMTST |
150:
LFSSPSVHNV | METVTQETAP | PDEMTTSFPS | SVTNTLMMTS | KTITMTTSTD |
200:
STLGNTEETS | TAGTESSTPV | TSAVSITAGQ | EGQSRTTSWR | TSIQDTSASS |
250:
QNHWTRSTQT | TRESQTSTLT | HRTTSTPSFS | PSVHNVTGTV | SQKTSPSGET |
300:
ATSSLCSVTN | TSMMTSEKIT | VTTSTGSTLG | NPGETSSVPV | TGSLMPVTSA |
350:
ALVTVDPEGQ | SPATFSRTST | QDTTAFSKNH | QTQSVETTRV | SQINTLNTLT |
400:
PVTTSTVLSS | PSGFNPSGTV | SQETFPSGET | TISSPSSVSN | TFLVTSKVFR |
450:
MPISRDSTLG | NTEETSLSVS | GTISAITSKV | STIWWSDTLS | TALSPSSLPP |
500:
KISTAFHTQQ | SEGAETTGRP | HERSSFSPGV | SQEIFTLHET | TTWPSSFSSK |
550:
GHTTWSQTEL | PSTSTGAATR | LVTGNPSTRA | AGTIPRVPSK | VSAIGEPGEP |
600:
TTYSSHSTTL | PKTTGAGAQT | QWTQETGTTG | EALLSSPSYS | VIQMIKTATS |
650:
PSSSPMLDRH | TSQQITTAPS | TNHSTIHSTS | TSPQESPAVS | QRGHTRAPQT |
700:
TQESQTTRSV | SPMTDTKTVT | TPGSSFTASG | HSPSEIVPQD | APTISAATTF |
750:
APAPTGNGHT | TQAPTTALQA | APSSHDATLG | PSGGTSLSKT | GALTLANSVV |
800:
STPGGPEGQW | TSASASTSPD | TAAAMTHTHQ | AESTEASGQT | QTSEPASSGS |
850:
RTTSAGTATP | SSSGASGTTP | SGSEGISTSG | ETTRFSSNPS | RDSHTTQSTT |
900:
ELLSASASHG | AIPVSTGMAS | SIVPGTFHPT | LSEASTAGRP | TGQSSPTSPS |
950:
ASPQETAAIS | RMAQTQRTGT | SRGSDTISLA | SQATDTFSTV | PPTPPSITSS |
1000:
GLTSPQTQTH | TLSPSGSGKT | FTTALISNAT | PLPVTSTSSA | STGHATPLAV |
1050:
SSATSASTVS | SDSPLKMETS | GMTTPSLKTD | GGRRTATSPP | PTTSQTIIST |
1100:
IPSTAMHTRS | TAAPIPILPE | RGVSLFPYGA | GAGDLEFVRR | TVDFTSPLFK |
1150:
PATGFPLGSS | LRDSLYFTDN | GQIIFPESDY | QIFSYPNPLP | TGFTGRDPVA |
1200:
LVAPFWDDAD | FSTGRGTTFY | QEYETFYGEH | SLLVQQAESW | IRKMTNNGGY |
1250:
KARWALKVTW | VNAHAYPAQW | TLGSNTYQAI | LSTDGSRSYA | LFLYQSGGMQ |
1300:
WDVAQRSGNP | VLMGFSSGDG | YFENSPLMSQ | PVWERYRPDR | FLNSNSGLQG |
1350:
LQFYRLHREE | RPNYRLECLQ | WLKSQPRWPS | WGWNQVSCPC | SWQQGRRDLR |
1400:
FQPVSIGRWG | LGSRQLCSFT | SWRGGVCCSY | GPWGEFREGW | HVQRPWQLAQ |
1450:
ELEPQSWCCR | WNDKPYLCAL | YQQRRPHVGC | ATYRPPQPAW | MFGDPHITTL |
1500:
DGVSYTFNGL | GDFLLVGAQD | GNSSFLLQGR | TAQTGSAQAT | NFIAFAAQYR |
1550:
SSSLGPVTVQ | WLLEPHDAIR | VLLDNQTVTF | QPDHEDGGGQ | ETFNATGVLL |
1600:
SRNGSEVSAS | FDGWATVSVI | ALSNILHASA | SLPPEYQNRT | EGLLGVWNNN |
1650:
PEDDFRMPNG | STIPPGSPEE | MLFHFGMTWQ | INGTGLLGKR | NDQLPSNFTP |
1700:
VFYSQLQKNS | SWAEHLISNC | DGDSSCIYDT | LALRNASIGL | HTREVSKNYE |
1750:
QANATLNQYP | PSINGGRVIE | AYKGQTTLIQ | YTSNAEDANF | TLRDSCTDLE |
1800:
LFENGTLLWT | PKSLEPFTLE | ILARSAKIGL | ASALQPRTVV | CHCNAESQCL |
1850:
YNQTSRVGNS | SLEVAGCKCD | GGTFGRYCEG | SEDACEEPCF | PSVHCVPGKG |
1900:
CEACPPNLTG | DGRHCAALGS | SFLCQNQSCP | VNYCYNQGHC | YISQTLGCQP |
1950:
MCTCPPAFTD | SRCFLAGNNF | SPTVNLELPL | RVIQLLLSEE | ENASMAEVNA |
2000:
SVAYRLGTLD | MRAFLRNSQV | ERIDSAAPAS | GSPIQHWMVI | SEFQYRPRGP |
2050:
VIDFLNNQLL | AAVVEAFLYH | VPRRSEEPRN | DVVFQPISGE | DVRDVTALNV |
2100:
STLKAYFRCD | GYKGYDLVYS | PQSGFTCVSP | CSRGYCDHGG | QCQHLPSGPR |
2150:
CSCVSFSIYT | AWGEHCEHLS | MKLDAFFGIF | FGALGGLLLL | GVGTFVVLRF |
2169:
WGCSGARFSY | FLNSAEALP
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
ELISA Kit for Human MUC-4
ELISA Kit for Human MUC-4
ELISA Kit for Human MUC-4
Polyclonal Antibody for Human MUC-4
Polyclonal Antibody for Human MUC-4
Polyclonal Antibody for Human MUC-4
Monoclonal Antibody for Human MUC-4
Monoclonal Antibody for Human MUC-4
Monoclonal Antibody for Human MUC-4
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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