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Index > Protein center > MUC4(Gene name) > Human
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  • MUC4 (Gene name),
  • Mucin-4 (Protein name ),  MUC4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MUC4;
    Protein name:
    Mucin-4(MUC-4);
    Alternative:
    Pancreatic adenocarcinoma mucin;Ascites sialoglycoprotein(ASGP);Tracheobronchial mucin;Testis mucin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3.
    Function:
    May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.
    Subcellular Location:
    Isoform 17 Cell membrane Single-pass membrane protein
    Protein Attributes:
    Sequence length:
    2169
    Sequence:
    50:
    MKGARWRRVP | WVSLSCLCLC | LLPHVVPGTT | EDTLITGSKT | AAPVTSTGST | 
    100:
    TATLEGQSTA | ASSRTSNQDI | SASSQNHQTK | STETTSKAQT | DTLTQMMTST | 
    150:
    LFSSPSVHNV | METVTQETAP | PDEMTTSFPS | SVTNTLMMTS | KTITMTTSTD | 
    200:
    STLGNTEETS | TAGTESSTPV | TSAVSITAGQ | EGQSRTTSWR | TSIQDTSASS | 
    250:
    QNHWTRSTQT | TRESQTSTLT | HRTTSTPSFS | PSVHNVTGTV | SQKTSPSGET | 
    300:
    ATSSLCSVTN | TSMMTSEKIT | VTTSTGSTLG | NPGETSSVPV | TGSLMPVTSA | 
    350:
    ALVTVDPEGQ | SPATFSRTST | QDTTAFSKNH | QTQSVETTRV | SQINTLNTLT | 
    400:
    PVTTSTVLSS | PSGFNPSGTV | SQETFPSGET | TISSPSSVSN | TFLVTSKVFR | 
    450:
    MPISRDSTLG | NTEETSLSVS | GTISAITSKV | STIWWSDTLS | TALSPSSLPP | 
    500:
    KISTAFHTQQ | SEGAETTGRP | HERSSFSPGV | SQEIFTLHET | TTWPSSFSSK | 
    550:
    GHTTWSQTEL | PSTSTGAATR | LVTGNPSTRA | AGTIPRVPSK | VSAIGEPGEP | 
    600:
    TTYSSHSTTL | PKTTGAGAQT | QWTQETGTTG | EALLSSPSYS | VIQMIKTATS | 
    650:
    PSSSPMLDRH | TSQQITTAPS | TNHSTIHSTS | TSPQESPAVS | QRGHTRAPQT | 
    700:
    TQESQTTRSV | SPMTDTKTVT | TPGSSFTASG | HSPSEIVPQD | APTISAATTF | 
    750:
    APAPTGNGHT | TQAPTTALQA | APSSHDATLG | PSGGTSLSKT | GALTLANSVV | 
    800:
    STPGGPEGQW | TSASASTSPD | TAAAMTHTHQ | AESTEASGQT | QTSEPASSGS | 
    850:
    RTTSAGTATP | SSSGASGTTP | SGSEGISTSG | ETTRFSSNPS | RDSHTTQSTT | 
    900:
    ELLSASASHG | AIPVSTGMAS | SIVPGTFHPT | LSEASTAGRP | TGQSSPTSPS | 
    950:
    ASPQETAAIS | RMAQTQRTGT | SRGSDTISLA | SQATDTFSTV | PPTPPSITSS | 
    1000:
    GLTSPQTQTH | TLSPSGSGKT | FTTALISNAT | PLPVTSTSSA | STGHATPLAV | 
    1050:
    SSATSASTVS | SDSPLKMETS | GMTTPSLKTD | GGRRTATSPP | PTTSQTIIST | 
    1100:
    IPSTAMHTRS | TAAPIPILPE | RGVSLFPYGA | GAGDLEFVRR | TVDFTSPLFK | 
    1150:
    PATGFPLGSS | LRDSLYFTDN | GQIIFPESDY | QIFSYPNPLP | TGFTGRDPVA | 
    1200:
    LVAPFWDDAD | FSTGRGTTFY | QEYETFYGEH | SLLVQQAESW | IRKMTNNGGY | 
    1250:
    KARWALKVTW | VNAHAYPAQW | TLGSNTYQAI | LSTDGSRSYA | LFLYQSGGMQ | 
    1300:
    WDVAQRSGNP | VLMGFSSGDG | YFENSPLMSQ | PVWERYRPDR | FLNSNSGLQG | 
    1350:
    LQFYRLHREE | RPNYRLECLQ | WLKSQPRWPS | WGWNQVSCPC | SWQQGRRDLR | 
    1400:
    FQPVSIGRWG | LGSRQLCSFT | SWRGGVCCSY | GPWGEFREGW | HVQRPWQLAQ | 
    1450:
    ELEPQSWCCR | WNDKPYLCAL | YQQRRPHVGC | ATYRPPQPAW | MFGDPHITTL | 
    1500:
    DGVSYTFNGL | GDFLLVGAQD | GNSSFLLQGR | TAQTGSAQAT | NFIAFAAQYR | 
    1550:
    SSSLGPVTVQ | WLLEPHDAIR | VLLDNQTVTF | QPDHEDGGGQ | ETFNATGVLL | 
    1600:
    SRNGSEVSAS | FDGWATVSVI | ALSNILHASA | SLPPEYQNRT | EGLLGVWNNN | 
    1650:
    PEDDFRMPNG | STIPPGSPEE | MLFHFGMTWQ | INGTGLLGKR | NDQLPSNFTP | 
    1700:
    VFYSQLQKNS | SWAEHLISNC | DGDSSCIYDT | LALRNASIGL | HTREVSKNYE | 
    1750:
    QANATLNQYP | PSINGGRVIE | AYKGQTTLIQ | YTSNAEDANF | TLRDSCTDLE | 
    1800:
    LFENGTLLWT | PKSLEPFTLE | ILARSAKIGL | ASALQPRTVV | CHCNAESQCL | 
    1850:
    YNQTSRVGNS | SLEVAGCKCD | GGTFGRYCEG | SEDACEEPCF | PSVHCVPGKG | 
    1900:
    CEACPPNLTG | DGRHCAALGS | SFLCQNQSCP | VNYCYNQGHC | YISQTLGCQP | 
    1950:
    MCTCPPAFTD | SRCFLAGNNF | SPTVNLELPL | RVIQLLLSEE | ENASMAEVNA | 
    2000:
    SVAYRLGTLD | MRAFLRNSQV | ERIDSAAPAS | GSPIQHWMVI | SEFQYRPRGP | 
    2050:
    VIDFLNNQLL | AAVVEAFLYH | VPRRSEEPRN | DVVFQPISGE | DVRDVTALNV | 
    2100:
    STLKAYFRCD | GYKGYDLVYS | PQSGFTCVSP | CSRGYCDHGG | QCQHLPSGPR | 
    2150:
    CSCVSFSIYT | AWGEHCEHLS | MKLDAFFGIF | FGALGGLLLL | GVGTFVVLRF | 
    2169:
    WGCSGARFSY | FLNSAEALP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    KEGG:
    Pfam:
    MIM:
    Uniprot:
     
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    Polyclonal Antibody for Human MUC-4
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    Polyclonal Antibody for Human MUC-4
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    Polyclonal Antibody for Human MUC-4
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    Packing:
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    Monoclonal Antibody for Human MUC-4
    Monoclonal Antibody for Human MUC-4
    Monoclonal Antibody for Human MUC-4
    Protein for Human MUC-4
    Protein for Human MUC-4
    Protein for Human MUC-4

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    References
    1. 1.
      "Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins."
      Moniaux N. , Escande F. , Batra S.K. , Porchet N. , Laine A. , Aubert J.-P.
      Eur. J. Biochem.267:4536-4544(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 12 AND 13);PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 11; 15; 16 AND 17);TISSUE SPECIFICITY;VARIANT ASP-1081
      tissue: Lung.
      tissue: Testis.
    2. 2.
      "Human MUC4 mucin cDNA and its variants in pancreatic carcinoma."
      Choudhury A. , Moniaux N. , Winpenny J.P. , Hollingsworth M.A. , Aubert J.-P. , Batra S.K.
      J. Biochem.128:233-243(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 5; 7; 8; 9; 10 AND 11);TISSUE SPECIFICITY;VARIANTS PRO-41 AND ASP-1081
      tissue: Pancreatic tumor.
    3. 3.
      "Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4."
      Desseyn J.-L. , Clavereau I. , Laine A.
      Eur. J. Biochem.269:3150-3159(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-41; ASP-1081 AND SER-1578
    4. 4.
      "Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin."
      Moniaux N. , Nollet S. , Porchet N. , Degand P. , Laine A. , Aubert J.-P.
      Biochem. J.338:325-333(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1014-2169 (ISOFORM 1);TISSUE SPECIFICITY;VARIANT ASP-1081
      tissue: Colon mucosa.
    5. 5.
      "Genomic organization of MUC4 mucin gene: towards the characterization of splice variants."
      Escande F. , Lemaitre L. , Moniaux N. , Batra S.K. , Aubert J.-P. , Buisine M.P.
      Eur. J. Biochem.269:3637-3644(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1014-2169;VARIANT ASP-1081
    6. 6.
      "Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs."
      Porchet N. , van Cong N. , Dufosse J. , Audie J.P. , Guyonnet-Duperat V. , Gross M.S. , Denis C. , Degand P. , Bernheim A. , Aubert J.-P.
      Biochem. Biophys. Res. Commun.175:414-422(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [MRNA]
    7. 7.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive."
      Carraway K.L. , Perez A. , Idris N. , Jepson S. , Arango M.E. , Komatsu M. , Haq B. , Price-Schiavi S.A. , Zhang J. , Carraway C.A.
      Prog. Nucleic Acid Res. Mol. Biol.71:149-185(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    9. 9.
      "MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas."
      Saitou M. , Goto M. , Horinouchi M. , Tamada S. , Nagata K. , Hamada T. , Osako M. , Takao S. , Batra S.K. , Aikou T. , Imai K. , Yonezawa S.
      J. Clin. Pathol.58:845-852(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "MUC4 expression and its relation to ErbB2 expression, apoptosis, proliferation, differentiation, and tumor stage in non-small cell lung cancer (NSCLC)."
      Karg A. , Dinc Z.A. , Basok O. , Ucvet A.
      Pathol. Res. Pract.202:577-583(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION
    11. 11.
      "MUC4 expression and localization in gastrointestinal tract and skin of human embryos."
      Zhang J. , Yasin M. , Carraway C.A. , Carraway K.L.
      Tissue Cell38:271-275(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;FUNCTION
    12. 12.
      "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
      Picariello G. , Ferranti P. , Mamone G. , Roepstorff P. , Addeo F.
      Proteomics8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1809
      tissue: Milk.
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