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Index > Protein center > MUM1(Gene name) > Human
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  • MUM1 (Gene name),
  • PWWP domain-containing protein MUM1 (Protein name ),  MUM1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MUM1(EXPAND1);
    Protein name:
    PWWP domain-containing protein MUM1;
    Alternative:
    Protein expandere;Mutated melanoma-associated antigen 1(MUM-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with TP53BP1 (via BRCT domain); the interaction is not dependent on its phosphorylation status. Binds nucleosomes.
    Function:
    Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.
    Subcellular Location:
    Nucleus Recuited to DNA damage sites via its interaction with the BRCT domain of TP53BP1.
    Protein Attributes:
    Sequence length:
    710
    Sequence:
    50:
    MADAKYVLCR | WEKRLWPAKV | LARTATSTKN | KRRKEYFLAV | QILSLEEKIK | 
    100:
    VKSTEVEILE | KSQIEAIASS | LASQNEVPAA | PLEELAYRRS | LRVALDVLSE | 
    150:
    GSIWSQESSA | GTGRADRSLR | GKPMEHVSSP | CDSNSSSLPR | GDVLGSSRPH | 
    200:
    RRRPCVQQSL | SSSFTCEKDP | ECKVDHKKGL | RKSENPRGPL | VLPAGGGAQD | 
    250:
    ESGSRIHHKN | WTLASKRGGN | SAQKASLCLN | GSSLSEDDTE | RDMGSKGGSW | 
    300:
    AAPSLPSGVR | EDDPCANAEG | HDPGLPLGSL | TAPPAPEPSA | CSEPGECPAK | 
    350:
    KRPRLDGSQR | PPAVQLEPMA | AGAAPSPGPG | PGPRESVTPR | STARLGPPPS | 
    400:
    HASADATRCL | PCPDSQKLEK | ECQSSEESMG | SNSMRSILEE | DEEDEEPPRV | 
    450:
    LLYHEPRSFE | VGMLVWHKHK | KYPFWPAVVK | SVRQRDKKAS | VLYIEGHMNP | 
    500:
    KMKGFTVSLK | SLKHFDCKEK | QTLLNQARED | FNQDIGWCVS | LITDYRVRLG | 
    550:
    CGSFAGSFLE | YYAADISYPV | RKSIQQDVLG | TKLPQLSKGS | PEEPVVGCPL | 
    600:
    GQRQPCRKML | PDRSRAARDR | ANQKLVEYIV | KAKGAESHLR | AILKSRKPSR | 
    650:
    WLQTFLSSSQ | YVTCVETYLE | DEGQLDLVVK | YLQGVYQEVG | AKVLQRTNGD | 
    700:
    RIRFILDVLL | PEAIICAISA | VDEVDYKTAE | EKYIKGPSLS | YREKEIFDNQ | 
    710:
    LLEERNRRRR | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human PWWP domain-containing protein MUM1
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    E1142h
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    ELISA Kit for Human PWWP domain-containing protein MUM1
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    ELISA Kit for Human PWWP domain-containing protein MUM1
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    Packing:
    96T
    CLIA Kit for Human PWWP domain-containing protein MUM1
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    U1142b
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    Packing:
    96T
    CLIA Kit for Human PWWP domain-containing protein MUM1
    Cat.:
    U1142r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PWWP domain-containing protein MUM1
    Cat.:
    U1142h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PWWP domain-containing protein MUM1
    Cat.:
    U1142m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PWWP domain-containing protein MUM1
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    P1142Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PWWP domain-containing protein MUM1
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    P1142Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PWWP domain-containing protein MUM1
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    P1142Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PWWP domain-containing protein MUM1
    Monoclonal Antibody for Human PWWP domain-containing protein MUM1
    Monoclonal Antibody for Human PWWP domain-containing protein MUM1
    Monoclonal Antibody for Human PWWP domain-containing protein MUM1
    Monoclonal Antibody for Human PWWP domain-containing protein MUM1
    Protein for Human PWWP domain-containing protein MUM1
    Protein for Human PWWP domain-containing protein MUM1
    Protein for Human PWWP domain-containing protein MUM1
    Protein for Human PWWP domain-containing protein MUM1

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    Precision
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    Linearity
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    References
    1. 1.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3);VARIANT ARG-219
      tissue: Brain.
      tissue: PNS.
    3. 3.
      "A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma."
      Coulie P.G. , Lehmann F. , Lethe B. , Herman J. , Lurquin C. , Andrawiss M. , Boon T.
      Proc. Natl. Acad. Sci. U.S.A.92:7976-7980(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-411;VARIANT ARG-219
      tissue: Melanoma.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 421-710 (ISOFORMS 1/2)
      tissue: Placenta.
      tissue: Thyroid.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    6. 6.
      "Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1."
      Huen M.S. , Huang J. , Leung J.W. , Sy S.M. , Leung K.M. , Ching Y.P. , Tsao S.W. , Chen J.
      Mol. Cell37:854-864(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION;DOMAIN PWWP;INTERACTION WITH TP53BP1 AND NUCLEOSOMES
    7. 7.
      "Structural and histone binding ability characterizations of human PWWP domains."
      Wu H. , Zeng H. , Lam R. , Tempel W. , Amaya M.F. , Xu C. , Dombrovski L. , Qiu W. , Wang Y. , Min J.
      PLoS ONE6:E18919-E18919(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.82 ANGSTROMS) OF 405-538;INTERACTION WITH TRIMETHYLATED HISTONE H3
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