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Index > Protein center > NAT8L(Gene name) > Human
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  • NAT8L (Gene name),
  • N-acetylaspartate synthetase (Protein name ),  NAT8L_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    NAT8L(CML3);
    Protein name:
    N-acetylaspartate synthetase(NAA synthetase);
    Alternative:
    N-acetyltransferase 8-like protein;Camello-like protein 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake.
    Subcellular Location:
    Cytoplasm Membrane Single-pass membrane protein Microsome membrane Single-pass membrane protein Mitochondrion membrane Single-pass membrane protein Rough endoplasmic reticulum membrane Single-pass membrane protein Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment.
    Protein Attributes:
    Sequence length:
    302
    Sequence:
    50:
    MHCGPPDMVC | ETKIVAAEDH | EALPGAKKDA | LLAAAGAMWP | PLPAAPGPAA | 
    100:
    APPAPPPAPV | AQPHGGAGGA | GPPGGRGVCI | REFRAAEQEA | ARRIFYDGIM | 
    150:
    ERIPNTAFRG | LRQHPRAQLL | YALLAALCFA | VSRSLLLTCL | VPAALLGLRY | 
    200:
    YYSRKVIRAY | LECALHTDMA | DIEQYYMKPP | GSCFWVAVLD | GNVVGIVAAR | 
    250:
    AHEEDNTVEL | LRMSVDSRFR | GKGIAKALGR | KVLEFAVVHN | YSAVVLGTTA | 
    300:
    VKVAAHKLYE | SLGFRHMGAS | DHYVLPGMTL | SLAERLFFQV | RYHRYRLQLR | 
    302:
    EE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human NAA synthetase
    Cat.:
    E4070r
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human NAA synthetase
    Cat.:
    E4070h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human NAA synthetase
    Cat.:
    E4070m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human NAA synthetase
    Cat.:
    U4070r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NAA synthetase
    Cat.:
    U4070m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human NAA synthetase
    Cat.:
    U4070h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human NAA synthetase
    Cat.:
    P4070Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NAA synthetase
    Cat.:
    P4070Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NAA synthetase
    Monoclonal Antibody for Human NAA synthetase
    Monoclonal Antibody for Human NAA synthetase
    Monoclonal Antibody for Human NAA synthetase
    Protein for Human NAA synthetase
    Protein for Human NAA synthetase
    Protein for Human NAA synthetase

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    References
    1. 1.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation."
      Brandenberger R. , Wei H. , Zhang S. , Lei S. , Murage J. , Fisk G.J. , Li Y. , Xu C. , Fang R. , Guegler K. , Rao M.S. , Mandalam R. , Lebkowski J. , Stanton L.W.
      Nat. Biotechnol.22:707-716(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 101-291
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-302
      tissue: Brain.
      tissue: PNS.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 117-302
      tissue: Brain.
    5. 5.
      "Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis."
      Popsueva A.E. , Luchinskaya N.N. , Ludwig A.V. , Zinovjeva O.Y. , Poteryaev D.A. , Feigelman M.M. , Ponomarev M.B. , Berekelya L. , Belyavsky A.V.
      Dev. Biol.234:483-496(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION
    6. 6.
      "Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells."
      Arun P. , Moffett J.R. , Namboodiri A.M.
      Neurochem. Int.55:219-225(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    7. 7.
      "Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia."
      Wiame E. , Tyteca D. , Pierrot N. , Collard F. , Amyere M. , Noel G. , Desmedt J. , Nassogne M.C. , Vikkula M. , Octave J.N. , Vincent M.F. , Courtoy P.J. , Boltshauser E. , van Schaftingen E.
      Biochem. J.425:127-136(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INVOLVEMENT IN NACED
    8. 8.
      "Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS."
      Ariyannur P.S. , Moffett J.R. , Manickam P. , Pattabiraman N. , Arun P. , Nitta A. , Nabeshima T. , Madhavarao C.N. , Namboodiri A.M.
      Brain Res.1335:1-13(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;INDUCTION BY METHAMPHETAMINE;SUBCELLULAR LOCATION
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