Gene name:
Ncor1 (Rxrip13) ;
Protein name:
Nuclear receptor corepressor 1 (N-CoR;N-CoR1) ;
Alternative:
Retinoid X receptor-interacting protein 13 (RIP13) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with HEXIM1 (By similarity). Interacts with C1D, SIAH2, HDAC7, SAP30, SIN3A and SIN3B. Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2.
Function:
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSSSGYPPNQ | GAFSTEQSRY | PSHSVQYTFP | SARHQQEFAV | PDYRSSHLEV |
100:
SQASQLLQQQ | QQQQLRRRPS | LLSEFHPGSD | RPQERRSGYE | QFHPGPSPVD |
150:
HDSLESKRPR | LEQVSDSHFQ | RISAAVLPLV | HTLPEGLRSS | ANAKKDPAFG |
200:
VKHEAPSSPL | SGQPCGDDQN | ASPSKLSKEE | LIQSMDRVDR | EIAKVEQQIL |
250:
KLKKKQQQLE | EEAAKPPEPE | KPVSPPPVEQ | KHRSIVQIIY | DENRKKAEEA |
300:
HKIFEGLGPK | VELPLYNQPS | DTKVYHENIK | TNQVMRKKLI | LFFKRRNHAR |
350:
KQREQKICQR | YDQLMEAWEK | KVDRIENNPR | RKAKESKTRE | YYEKQFPEIR |
400:
KQREQQERFQ | RVGQRGAGLS | ATIARSEHEI | SEIIDGLSEQ | ENNEKQMRQL |
450:
SVIPPMMFDA | EQRRVKFINM | NGLMEDPMKV | YKDRQFMNVW | TDHEKEIFKD |
500:
KFIQHPKNFG | LIASYLERKS | VPDCVLYYYL | TKKNENYKAL | VRRNYGKRRG |
550:
RNQQIARPSQ | EEKVEEKEED | KAEKTEKKEE | EKKDDEEKDD | KEDSKETTKE |
600:
KDRTEATAEE | PEEREQVTPR | GRKTANSQGR | GKGRVTRSMT | SEAAAANAAA |
650:
AATEEPPPPL | PPPPEPISTE | PVETSRWTEE | EMEVAKKGLV | EHGRNWAAIA |
700:
KMVGTKSEAQ | CKNFYFNYKR | RHNLDNLLQQ | HKQKASRKPR | EERDVSQCES |
750:
VASTVSAQED | EDIEASNEEE | NPEDSEGAEN | SSDTESAPSP | SPVEAAKSSE |
800:
DSSENAASRG | NTEPVAELEA | TTDPAPCASP | SSAVPTTKPA | ERESVEAQVT |
850:
DSASAETAEP | MDVDHEECGA | EGSSVLDPPA | PTKADSVDPE | MQVPENTASK |
900:
GEGDAKERDL | ESTSEKTEAR | DEDVVVAEQI | ERPEPQSDDD | SSATCSADEG |
950:
VDGEPERQRV | FPMDAKPSLL | TPPGSILISS | PIKPNLLDLP | QLQHRAAVIP |
1000:
PMVSCTPCNI | PIGTPVSGYA | LYQRHIKAMH | ESALLEEQRQ | RQEQVDLECR |
1050:
SSTSPCSTSK | SPNREWEVLQ | PAPHQVITNL | PEGVRLPTTR | PTRPPPPLIP |
1100:
SSKTTVASEK | PSFIMGGSIS | QGTPGTYLSS | HNQAYPQEAP | KPSVGSISLG |
1150:
LPRQQESTKA | APLTYIKQEE | FSPRSQNSQP | EGLLVRAQHE | GVVRGTAGAV |
1200:
QEGSITRGTP | ASKISVETIS | SLRGSITQGT | PALPQAGIPT | EALVKGPVSR |
1250:
MPIEESSPEK | VREEAASKGH | VIYEGKSGHI | LSYDNIKNAR | EGTRSPRTAH |
1300:
EMSLKRSYEA | VEGSIKQGMS | MRESPVSAPL | EGLICRALPR | GSPHSDLKER |
1350:
TVLSGSIMQG | TPRATAESFE | DGLKYPKQIK | RESPPIRAFE | GAITKGKPYD |
1400:
GITTIKEMGR | SIHEIPRQDI | LTQESRKTPE | VVQSTRPIIE | GSISQGTPIK |
1450:
FDNNSGQSAI | KHNVKSLITG | PSKLPRGMLE | IVPENIKVVE | RGKYEDVKAG |
1500:
EPVRARHTSV | VSSGPSVLRS | TLHEAPKAQL | SPGLYDDSSA | RRTPVSYQNT |
1550:
ISRGSPMMNR | TSDVSSSKSA | SHERKSTLTP | TQRESIPAKS | PVPGVDPIVS |
1600:
HSPFDPHHRS | SAAGEVYRSH | LPTHLDPAMP | FHRALDPAAA | YLLQRQLSPT |
1650:
PGYPSQYQLY | AMENTRQTIL | NDYITSQQMQ | VNLRPDVTRG | LSPREQPLGL |
1700:
PYPATRGIID | LTNMPPTILV | PHAGGTSTPP | MDRITYIPGT | QVTFPPRPYN |
1750:
AASLSPGHPT | HLAAAASAER | EREREREKER | ERERERERER | ERERIAAAPA |
1800:
DLYLRPGSEQ | PGRPGSHGYV | RSPSPSVRTQ | ETILQQRPSV | FQGTNGTSVI |
1850:
TPLDPTAQLR | IMPLPSGGPS | ISQGLPASRY | NTAADALAAL | VDAAASAPQM |
1900:
DVSKTKESKH | EAARLEENLR | SRSAAVSEQQ | QLEQKNLEVE | KRSVQCVCTS |
1950:
SALPSGKAQP | HASVVYSEAG | KDKGPPPKSR | YEEELRTRGK | TTITAANFID |
2000:
VIITRQIASD | KDARERGSQS | SDSSSSLSSH | RYETASDAIE | VISPASSPAP |
2050:
PQEKPQAYQP | DMVKANQAEN | ESTRQYEGPL | HHYRSQQESP | SPQQQPPLPP |
2100:
SSQSEGMGQV | PRTHRLITLA | DHICQIITQD | FARNQVPSQA | STSTFQTSPS |
2150:
ALSSTPVRTK | TSSRYSPESQ | SQTVLHPRPG | PRVSPENLVD | KSRGSRPGKS |
2200:
PERSHIPSEP | YEPISPPQGP | AVHEKQDSML | LLSQRGVDPA | EQRSDSRSPG |
2250:
SISYLPSFFT | KLESTSPMVK | SKKQEIFRKL | NSSGGGDSDM | AAAQPGTEIF |
2300:
NLPAVTTSGA | VSSRSHSFAD | PASNLGLEDI | IRKALMGSFD | DKVEDHGVVM |
2350:
SHPVGIMPGS | ASTSVVTSSE | ARRDEGEPSP | HAGVCKPKLI | NKSNSRKSKS |
2400:
PIPGQSYLGT | ERPSSVSSVH | SEGDYHRQTP | GWAWEDRPSS | TGSTQFPYNP |
2450:
LTIRMLSSTP | PTQIACAPSA | ITQAAPHQQN | RIWEREPAPL | LSAQYETLSD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse N-CoR
ELISA Kit for Mouse N-CoR
ELISA Kit for Mouse N-CoR
Polyclonal Antibody for Mouse N-CoR
Polyclonal Antibody for Mouse N-CoR
Polyclonal Antibody for Mouse N-CoR
Monoclonal Antibody for Mouse N-CoR
Monoclonal Antibody for Mouse N-CoR
Monoclonal Antibody for Mouse N-CoR
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor."
Hoerlein A.J.
,
Naeaer A.M.
,
Heinzel T.
,
Torchia J.
,
Gloss B.
,
Kurokawa R.
,
Ryan A.
,
Kamei Y.
,
Soederstroem M.
,
Glass C.K.
,
Rosenfeld M.G.
Nature377:397-404(1995)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue :
Pituitary .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1792-2453 (ISOFORM 1)
tissue :
Liver .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RARB; RXRA AND THRB;DOMAINS ID1 AND ID2
4.
"A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression."
Heinzel T.
,
Lavinsky R.M.
,
Mullen T.-M.
,
Soederstroem M.
,
Laherty C.D.
,
Torchia J.
,
Yang W.M.
,
Brard G.
,
Ngo S.D.
,
Davie J.R.
,
Seto E.
,
Eisenman R.N.
,
Rose D.W.
,
Glass C.K.
,
Rosenfeld M.G.
Nature387:43-48(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SIN3A AND SIN3B
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH C1D
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SIAH2;DEGRADATION
7.
"SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors."
Laherty C.D.
,
Billin A.N.
,
Lavinsky R.M.
,
Yochum G.S.
,
Bush A.C.
,
Sun J.-M.
,
Mullen T.-M.
,
Davie J.R.
,
Rose D.W.
,
Glass C.K.
,
Rosenfeld M.G.
,
Ayer D.E.
,
Eisenman R.N.
Mol. Cell2:33-42(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SAP30 AND SIN3A
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HDAC7
9.
"ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
Amann J.M.
,
Nip J.
,
Strom D.K.
,
Lutterbach B.
,
Harada H.
,
Lenny N.
,
Downing J.R.
,
Meyers S.
,
Hiebert S.W.
Mol. Cell. Biol.21:6470-6483(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CBFA2T3
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DACH1
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RARA
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1481; SER-2449 AND SER-2451;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RARA
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224 AND SER-1481;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2198;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RXRA
17.
"Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand."
Solt L.A.
,
Kumar N.
,
Nuhant P.
,
Wang Y.
,
Lauer J.L.
,
Liu J.
,
Istrate M.A.
,
Kamenecka T.M.
,
Roush W.R.
,
Vidovic D.
,
Schuerer S.C.
,
Xu J.
,
Wagoner G.
,
Drew P.D.
,
Griffin P.R.
,
Burris T.P.
Nature472:491-494(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RORA AND RORC
18.
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J.
,
Chen Y.
,
Tishkoff D.X.
,
Peng C.
,
Tan M.
,
Dai L.
,
Xie Z.
,
Zhang Y.
,
Zwaans B.M.
,
Skinner M.E.
,
Lombard D.B.
,
Zhao Y.
Mol. Cell50:919-930(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1347;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .