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Index > Protein center > IKBKG(Gene name) > Human
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  • IKBKG (Gene name),
  • NF-kappa-B essential modulator (Protein name ),  NEMO_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IKBKG(FIP3;NEMO);
    Protein name:
    NF-kappa-B essential modulator(NEMO);
    Alternative:
    IkB kinase-associated protein 1(IKKAP1);FIP-3;NF-kappa-B essential modifier;Inhibitor of nuclear factor kappa-B kinase subunit gamma(I-kappa-B kinase subunit gamma;IKK-gamma;IKKG;IkB kinase subunit gamma);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD, NALP2, TRPC4AP and LRDD. Interacts with ATM; the complex is exported from the nucleus. Interacts with TRAF6. Interacts with HTLV-1 Tax oncoprotein; the interaction activates IKBKG. Interacts with TANK; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with ZFAND5. Interacts with RIPK2.
    Function:
    Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity (By similarity). Essential for viral activation of IRF3.
    Subcellular Location:
    Cytoplasm Nucleus Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.
    Protein Attributes:
    Sequence length:
    419
    Sequence:
    50:
    MNRHLWKSQL | CEMVQPSGGP | AADQDVLGEE | SPLGKPAMLH | LPSEQGAPET | 
    100:
    LQRCLEENQE | LRDAIRQSNQ | ILRERCEELL | HFQASQREEK | EFLMCKFQEA | 
    150:
    RKLVERLGLE | KLDLKRQKEQ | ALREVEHLKR | CQQQMAEDKA | SVKAQVTSLL | 
    200:
    GELQESQSRL | EAATKECQAL | EGRARAASEQ | ARQLESEREA | LQQQHSVQVD | 
    250:
    QLRMQGQSVE | AALRMERQAA | SEEKRKLAQL | QVAYHQLFQE | YDNHIKSSVV | 
    300:
    GSERKRGMQL | EDLKQQLQQA | EEALVAKQEV | IDKLKEEAEQ | HKIVMETVPV | 
    350:
    LKAQADIYKA | DFQAERQARE | KLAEKKELLQ | EQLEQLQREY | SKLKASCQES | 
    400:
    ARIEDMRKRH | VEVSQAPLPP | APAYLSSPLA | LPSQRRSPPE | EPPDFCCPKC | 
    419:
    QYQAPDMDTL | QIHVMECIE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    Pfam:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human NEMO
    Cat.:
    E9868h
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    Packing:
    96T
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    ELISA Kit for Human NEMO
    Cat.:
    E9868m
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    Packing:
    96T
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    ELISA Kit for Human NEMO
    Cat.:
    E9868r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human NEMO
    Cat.:
    E9868b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human NEMO
    Cat.:
    U9868m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human NEMO
    Cat.:
    U9868b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human NEMO
    Cat.:
    U9868r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NEMO
    Cat.:
    U9868h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human NEMO
    Cat.:
    P9868Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NEMO
    Polyclonal Antibody for Human NEMO
    Polyclonal Antibody for Human NEMO
    Cat.:
    P9868Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human NEMO
    Monoclonal Antibody for Human NEMO
    Monoclonal Antibody for Human NEMO
    Monoclonal Antibody for Human NEMO
    Protein for Human NEMO
    Protein for Human NEMO
    Protein for Human NEMO
    Protein for Human NEMO

    R&D Technical Data

    s

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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤6.8%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤9.2%

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    Recovery

    Recovery was determined by spiking various levels of NEMOinto serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    96

    89-102

    Plasma

    97

    91-105

     

     

     

     

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of NEMO and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    90-103%

    92-102%

    89-104%

    91-107%

    EDTA plasma(n=5)

    93-101%

    94-100%

    90-103%

    89-106%

    heparin plasma(n=5)

    92-103%

     

    91-105%

    94-101%

    93-102%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis."
      Li Y. , Kang J. , Friedman J. , Tarassishin L. , Ye J. , Kovalenko A. , Wallach D. , Horwitz M.S.
      Proc. Natl. Acad. Sci. U.S.A.96:1042-1047(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28."
      Jin D.-Y. , Jeang K.-T.
      J. Biomed. Sci.6:115-120(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Mammary cancer.
    3. 3.
      "IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex."
      Rothwarf D.M. , Zandi E. , Natoli G. , Karin M.
      Nature395:297-300(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
      tissue: Cervix carcinoma.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT IP VAL-407
    5. 5.
      "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs."
      Ye Z. , Connor J.R.
      Biochem. Biophys. Res. Commun.275:223-227(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Astrocytoma.
    6. 6.
      "Ikbkg gene modulates the herpes virus susceptibility in mice."
      Perelygin A.A. , Perelygina L.M.
      Submitted (2002-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
    8. 8.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    9. 9.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
      tissue: Placenta.
      tissue: Skin.
    11. 11.
      "IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex."
      Mercurio F. , Murray B.W. , Shevchenko A. , Bennett B.L. , Young D.B. , Li J.W. , Pascual G. , Motiwala A. , Zhu H. , Mann M. , Manning A.M.
      Mol. Cell. Biol.19:1526-1538(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-419 (ISOFORM 1);PROTEIN SEQUENCE OF 144-159
      tissue: Cervix carcinoma.
    12. 12.
      "Role of adapter function in oncoprotein-mediated activation of NF-kappaB: human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma."
      Jin D.-Y. , Giordano V. , Kibler K.V. , Nakano H. , Jeang K.-T.
      J. Biol. Chem.274:17402-17405(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HTLV-1 TAX-1
    13. 13.
      "Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein."
      Xiao G. , Sun S.C.
      Oncogene19:5198-5203(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HTLV-1 TAX-1
    14. 14.
      "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions."
      Klinkenberg M. , Van Huffel S. , Heyninck K. , Beyaert R.
      FEBS Lett.498:93-97(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFAIP3
    15. 15.
      "CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation."
      Hong X. , Xu L.-G. , Li X. , Zhai Z. , Shu H.-B.
      FEBS Lett.499:133-136(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPS3
    16. 16.
      "Role of ikkgamma/nemo in assembly of the IkappaB kinase complex."
      Li X.-H. , Fang X. , Gaynor R.B.
      J. Biol. Chem.276:4494-4500(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT OF THE IKK COMPLEX
    17. 17.
      "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases."
      Chariot A. , Leonardi A. , Muller J. , Bonif M. , Brown K. , Siebenlist U.
      J. Biol. Chem.277:37029-37036(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TANK AND IKBKB
    18. 18.
      "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase."
      Wu R.-C. , Qin J. , Hashimoto Y. , Wong J. , Xu J. , Tsai S.Y. , Tsai M.-J. , O'Malley B.W.
      Mol. Cell. Biol.22:3549-3561(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT OF A COMPLEX CONTAINING CREBBP; NCOA2; NCOA3; IKKA AND IKKB
    19. 19.
      "Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress."
      Huang T.T. , Wuerzberger-Davis S.M. , Wu Z.H. , Miyamoto S.
      Cell115:565-576(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-277 AND LYS-309;UBIQUITINATION AT LYS-277 AND LYS-309;MUTAGENESIS OF LYS-277 AND LYS-309;SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANT EDAID ARG-417
    20. 20.
      "In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase."
      Carter R.S. , Pennington K.N. , Ungurait B.J. , Ballard D.W.
      J. Biol. Chem.278:19642-19648(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-31; SER-43 AND SER-376
    21. 21.
      "Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation."
      Tegethoff S. , Behlke J. , Scheidereit C.
      Mol. Cell. Biol.23:2029-2041(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SELF-ASSOCIATION;COMPOSITION OF THE IKK COMPLEX
    22. 22.
      "The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination."
      Kovalenko A. , Chable-Bessia C. , Cantarella G. , Israeel A. , Wallach D. , Courtois G.
      Nature424:801-805(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CYLD
    23. 23.
      "The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO."
      Abbott D.W. , Wilkins A. , Asara J.M. , Cantley L.C.
      Curr. Biol.14:2217-2227(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-285;MUTAGENESIS OF LYS-115; LYS-224; LYS-285 AND LYS-399
    24. 24.
      "ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation."
      Huang J. , Teng L. , Li L. , Liu T. , Li L. , Chen D. , Xu L.-G. , Zhai Z. , Shu H.-B.
      J. Biol. Chem.279:16847-16853(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZFAND5
    25. 25.
      "PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages."
      Bruey J.-M. , Bruey-Sedano N. , Newman R. , Chandler S. , Stehlik C. , Reed J.C.
      J. Biol. Chem.279:51897-51907(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NALP2
    26. 26.
      "The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes."
      Sun L. , Deng L. , Ea C.-K. , Xia Z.-P. , Chen Z.J.
      Mol. Cell14:289-301(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
    27. 27.
      "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO."
      Zhou H. , Wertz I. , O'Rourke K. , Ultsch M. , Seshagiri S. , Eby M. , Xiao W. , Dixit V.M.
      Nature427:167-171(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;UBIQUITINATION AT LYS-399;MUTAGENESIS OF LYS-399
    28. 28.
      "PIDD mediates NF-kappaB activation in response to DNA damage."
      Janssens S. , Tinel A. , Lippens S. , Tschopp J.
      Cell123:1079-1092(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRDD
    29. 29.
      "Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation."
      Wu C.J. , Conze D.B. , Li T. , Srinivasula S.M. , Ashwell J.D.
      Nat. Cell Biol.8:398-406(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITIN-BINDING;MUTAGENESIS OF LEU-329;CHARACTERIZATION OF VARIANT EDAID ASN-311
    30. 30.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    31. 31.
      "Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli."
      Wu Z.H. , Shi Y. , Tibbetts R.S. , Miyamoto S.
      Science311:1141-1146(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATM;PHOSPHORYLATION AT SER-85;MUTAGENESIS OF SER-85
    32. 32.
      "Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation."
      Lamothe B. , Besse A. , Campos A.D. , Webster W.K. , Wu H. , Darnay B.G.
      J. Biol. Chem.282:4102-4112(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
    33. 33.
      "Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347."
      Herscovitch M. , Comb W. , Ennis T. , Coleman K. , Yong S. , Armstead B. , Kalaitzidis D. , Chandani S. , Gilmore T.D.
      Biochem. Biophys. Res. Commun.367:103-108(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;DISULFIDE BONDS
    34. 34.
      "A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation."
      Hasegawa M. , Fujimoto Y. , Lucas P.C. , Nakano H. , Fukase K. , Nunez G. , Inohara N.
      EMBO J.27:373-383(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIPK2
    35. 35.
      "Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity."
      Palkowitsch L. , Leidner J. , Ghosh S. , Marienfeld R.B.
      J. Biol. Chem.283:76-86(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKBKB;PHOSPHORYLATION AT SER-68;MUTAGENESIS OF SER-68
    36. 36.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    37. 37.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    38. 38.
      "The zinc finger of NEMO is a functional ubiquitin-binding domain."
      Cordier F. , Grubisha O. , Traincard F. , Veron M. , Delepierre M. , Agou F.
      J. Biol. Chem.284:2902-2907(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITIN-BINDING;MUTAGENESIS OF VAL-414 AND MET-415;CHARACTERIZATION OF VARIANT IP VAL-407
    39. 39.
      "Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3."
      Zeng W. , Xu M. , Liu S. , Sun L. , Chen Z.J.
      Mol. Cell36:315-325(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN LEUCINE-ZIPPER AND C2HC-TYPE ZINC-FINGER
    40. 40.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-285 AND LYS-309
    41. 41.
      "DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding."
      Grubisha O. , Kaminska M. , Duquerroy S. , Fontan E. , Cordier F. , Haouz A. , Raynal B. , Chiaravalli J. , Delepierre M. , Israel A. , Veron M. , Agou F.
      J. Mol. Biol.395:89-104(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF GLU-296; PHE-312; GLU-315; ALA-323; LEU-329 AND LEU-336
    42. 42.
      "A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response."
      Ashida H. , Kim M. , Schmidt-Supprian M. , Ma A. , Ogawa M. , Sasakawa C.
      Nat. Cell Biol.12:66-73(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHIGELLA FLEXNERI IPAH9.8;UBIQUITINATION AT LYS-309 AND LYS-321
    43. 43.
      "Polyubiquitin conjugation to NEMO by tripartite motif protein 23 (TRIM23) is critical in antiviral defense."
      Arimoto K. , Funami K. , Saeki Y. , Tanaka K. , Okawa K. , Takeuchi O. , Akira S. , Murakami Y. , Shimotohno K.
      Proc. Natl. Acad. Sci. U.S.A.107:15856-15861(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;UBIQUITINATION
    44. 44.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    45. 45.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    46. 46.
      "TRIM40 promotes neddylation of IKKgamma and is downregulated in gastrointestinal cancers."
      Noguchi K. , Okumura F. , Takahashi N. , Kataoka A. , Kamiyama T. , Todo S. , Hatakeyama S.
      Carcinogenesis32:995-1004(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NEDDYLATION BY TRIM40
    47. 47.
      "Polyubiquitin binding to ABIN1 is required to prevent autoimmunity."
      Nanda S.K. , Venigalla R.K. , Ordureau A. , Patterson-Kane J.C. , Powell D.W. , Toth R. , Arthur J.S. , Cohen P.
      J. Exp. Med.208:1215-1228(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITIN-BINDING;CHARACTERIZATION OF VARIANT EDAID ASN-311
    48. 48.
      "Direct, noncatalytic mechanism of IKK inhibition by A20."
      Skaug B. , Chen J. , Du F. , He J. , Ma A. , Chen Z.J.
      Mol. Cell44:559-571(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFAIP3
    49. 49.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY THE LUBAC COMPLEX
    50. 50.
      "SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex."
      Tokunaga F. , Nakagawa T. , Nakahara M. , Saeki Y. , Taniguchi M. , Sakata S. , Tanaka K. , Nakano H. , Iwai K.
      Nature471:633-636(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY THE LUBAC COMPLEX
    51. 51.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-277; LYS-285; LYS-309; LYS-326; LYS-111; LYS-143; LYS-226; LYS-246; LYS-264; LYS-292 AND LYS-302 BY THE LUBAC COMPLEX;UBIQUITINATION AT LYS-139 AND LYS-283
    52. 52.
      "NLRP10 enhances Shigella-induced pro-inflammatory responses."
      Lautz K. , Damm A. , Menning M. , Wenger J. , Adam A.C. , Zigrino P. , Kremmer E. , Kufer T.A.
      Cell. Microbiol.14:1568-1583(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLRP10
    53. 53.
      "IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex."
      Zhou A.Y. , Shen R.R. , Kim E. , Lock Y.J. , Xu M. , Chen Z.J. , Hahn W.C.
      Cell Rep.3:724-733(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKBKE
    54. 54.
      "Identifying post-translational modifications of NEMO by tandem mass spectrometry after high affinity purification."
      Jackson S.S. , Coughlin E.E. , Coon J.J. , Miyamoto S.
      Protein Expr. Purif.92:48-53(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-387
    55. 55.
      "Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation."
      Cordier F. , Vinolo E. , Veron M. , Delepierre M. , Agou F.
      J. Mol. Biol.377:1419-1432(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 394-419 OF WILD-TYPE AND MUTANT PHE-417;DOMAIN ZINC-FINGER
    56. 56.
      "Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site."
      Rushe M. , Silvian L. , Bixler S. , Chen L.L. , Cheung A. , Bowes S. , Cuervo H. , Berkowitz S. , Zheng T. , Guckian K. , Pellegrini M. , Lugovskoy A.
      Structure16:798-808(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 44-111 IN COMPLEX WITH CHUK AND IKBKB;SUBUNIT
    57. 57.
      "Structural basis for recognition of diubiquitins by NEMO."
      Lo Y.C. , Lin S.C. , Rospigliosi C.C. , Conze D.B. , Wu C.J. , Ashwell J.D. , Eliezer D. , Wu H.
      Mol. Cell33:602-615(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 246-337;UBIQUITIN-BINDING;MUTAGENESIS OF VAL-300; LEU-301; GLN-304; ILE-307; TYR-308; PHE-312; GLN-313 AND GLN-317;CHARACTERIZATION OF VARIANT EDAID ASN-311;CHARACTERIZATION OF VARIANT IMD33 ALA-315;CHARACTERIZATION OF VARIANTS GLN-319 AND IP PRO-323
    58. 58.
      "A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO)."
      Zonana J. , Elder M.E. , Schneider L.C. , Orlow S.J. , Moss C. , Golabi M. , Shapira S.K. , Farndon P.A. , Wara D.W. , Emmal S.A. , Ferguson B.M.
      Am. J. Hum. Genet.67:1555-1562(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EDAID ARG-417 AND PHE-417
    59. 59.
      "A recurrent deletion in the ubiquitously expressed NEMO (IKK-gamma) gene accounts for the vast majority of incontinentia pigmenti mutations."
      Aradhya S. , Woffendin H. , Jakins T. , Bardaro T. , Esposito T. , Smahi A. , Shaw C. , Levy M. , Munnich A. , D'Urso M. , Lewis R.A. , Kenwrick S. , Nelson D.L.
      Hum. Mol. Genet.10:2171-2179(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IP LYS-57 AND VAL-407
    60. 60.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EDAID PRO-175; PRO-227; GLY-288; ASN-311; ARG-417 AND PHE-417
    61. 61.
      "Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia."
      Jain A. , Ma C.A. , Liu S. , Brown M. , Cohen J. , Strober W.
      Nat. Immunol.2:223-228(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EDAID VAL-406 AND ARG-417
    62. 62.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EDAID ARG-153 AND ARG-417
    63. 63.
      "Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation."
      Fusco F. , Bardaro T. , Fimiani G. , Mercadante V. , Miano M.G. , Falco G. , Israeel A. , Courtois G. , D'Urso M. , Ursini M.V.
      Hum. Mol. Genet.13:1763-1773(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IP LYS-57; LYS-90 DEL AND TRP-123;VARIANT ASN-113;CHARACTERIZATION OF VARIANTS IP LYS-57; LYS-90 DEL AND TRP-123;CHARACTERIZATION OF VARIANT ASN-113
    64. 64.
      "The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation."
      Orange J.S. , Jain A. , Ballas Z.K. , Schneider L.C. , Geha R.S. , Bonilla F.A.
      J. Allergy Clin. Immunol.113:725-733(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EDAID ARG-153 AND ARG-417;VARIANT NEMOID TYR-417
    65. 65.
      "Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia."
      Orange J.S. , Levy O. , Brodeur S.R. , Krzewski K. , Roy R.M. , Niemela J.E. , Fleisher T.A. , Bonilla F.A. , Geha R.S.
      J. Allergy Clin. Immunol.114:650-656(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN NEMOID
    66. 66.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IMD33 ALA-315 AND GLN-319
    67. 67.
      "Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti."
      Sebban-Benin H. , Pescatore A. , Fusco F. , Pascuale V. , Gautheron J. , Yamaoka S. , Moncla A. , Ursini M.V. , Courtois G.
      Hum. Mol. Genet.16:2805-2815(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IP PRO-323;CHARACTERIZATION OF VARIANT IP PRO-323;INTERACTION WITH TRAF6
    68. 68.
      "IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease."
      Ku C.-L. , Picard C. , Erdos M. , Jeurissen A. , Bustamante J. , Puel A. , von Bernuth H. , Filipe-Santos O. , Chang H.-H. , Lawrence T. , Raes M. , Marodi L. , Bossuyt X. , Casanova J.-L.
      J. Med. Genet.44:16-23(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IPD2 GLY-173
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