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Index > Protein center > Nfe2l2(Gene name) > Mouse
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  • Nfe2l2 (Gene name),
  • Nuclear factor erythroid 2-related factor 2 (Protein name ),  NF2L2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Nfe2l2(Nrf-2;Nrf2);
    Protein name:
    Nuclear factor erythroid 2-related factor 2(NF-E2-related factor 2;NFE2-related factor 2);
    Alternative:
    Nuclear factor, erythroid derived 2, like 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimer. Forms a ternary complex with PGAM5 and KEAP1 (By similarity). Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.
    Function:
    Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
    Subcellular Location:
    Cytoplasm cytosol Nucleus Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
    Protein Attributes:
    Sequence length:
    597
    Sequence:
    50:
    MMDLELPPPG | LQSQQDMDLI | DILWRQDIDL | GVSREVFDFS | QRQKDYELEK | 
    100:
    QKKLEKERQE | QLQKEQEKAF | FAQFQLDEET | GEFLPIQPAQ | HIQTDTSGSA | 
    150:
    SYSQVAHIPK | QDALYFEDCM | QLLAETFPFV | DDHESLALDI | PSHAESSVFT | 
    200:
    APHQAQSLNS | SLEAAMTDLS | SIEQDMEQVW | QELFSIPELQ | CLNTENKQLA | 
    250:
    DTTAVPSPEA | TLTEMDSNYH | FYSSISSLEK | EVGNCGPHFL | HGFEDSFSSI | 
    300:
    LSTDDASQLT | SLDSNPTLNT | DFGDEFYSAF | IAEPSDGGSM | PSSAAISQSL | 
    350:
    SELLDGTIEG | CDLSLCKAFN | PKHAEGTMEF | NDSDSGISLN | TSPSRASPEH | 
    400:
    SVESSIYGDP | PPGFSDSEME | ELDSAPGSVK | QNGPKAQPAH | SPGDTVQPLS | 
    450:
    PAQGHSAPMR | ESQCENTTKK | EVPVSPGHQK | APFTKDKHSS | RLEAHLTRDE | 
    500:
    LRAKALHIPF | PVEKIINLPV | DDFNEMMSKE | QFNEAQLALI | RDIRRRGKNK | 
    550:
    VAAQNCRKRK | LENIVELEQD | LGHLKDEREK | LLREKGENDR | NLHLLKRRLS | 
    597:
    TLYLEVFSML | RDEDGKPYSP | SEYSLQQTRD | GNVFLVPKSK | KPDTKKN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    KEGG:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse NF-E2-related factor 2
    Cat.:
    E3093m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse NF-E2-related factor 2
    Cat.:
    E3093h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse NF-E2-related factor 2
    Cat.:
    E3093b
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Mouse NF-E2-related factor 2
    Cat.:
    E3093r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse NF-E2-related factor 2
    Cat.:
    U3093r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse NF-E2-related factor 2
    Cat.:
    U3093m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse NF-E2-related factor 2
    Cat.:
    U3093b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse NF-E2-related factor 2
    Cat.:
    U3093h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse NF-E2-related factor 2
    Cat.:
    P3093Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse NF-E2-related factor 2
    Cat.:
    P3093Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse NF-E2-related factor 2
    Polyclonal Antibody for Mouse NF-E2-related factor 2
    Cat.:
    P3093Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse NF-E2-related factor 2
    Monoclonal Antibody for Mouse NF-E2-related factor 2
    Monoclonal Antibody for Mouse NF-E2-related factor 2
    Monoclonal Antibody for Mouse NF-E2-related factor 2
    Protein for Mouse NF-E2-related factor 2
    Protein for Mouse NF-E2-related factor 2
    Protein for Mouse NF-E2-related factor 2
    Protein for Mouse NF-E2-related factor 2

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    References
    1. 1.
      "NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development."
      Chan K. , Lu R. , Chang J.C. , Kan Y.W.
      Proc. Natl. Acad. Sci. U.S.A.93:13943-13948(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: 129/SvJ.
      tissue: Lung.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryonic lung.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Czech II.
      tissue: Mammary gland.
    5. 5.
      "cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor."
      Chui D.H.K. , Tang W. , Orkin S.H.
      Biochem. Biophys. Res. Commun.209:40-46(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-597
      strain: C57BL/6J.
      tissue: Erythroblast.
    6. 6.
      "Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain."
      Itoh K. , Wakabayashi N. , Katoh Y. , Ishii T. , Igarashi K. , Engel J.D. , Yamamoto M.
      Genes Dev.13:76-86(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH KEAP1
    7. 7.
      "Cloning and characterization of the mouse polyamine-modulated factor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor."
      Wang Y. , Devereux W. , Woster P.M. , Casero R.A. Jr.
      Biochem. J.359:387-392(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NFE2L2
    8. 8.
      "Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer."
      Padmanabhan B. , Tong K.I. , Ohta T. , Nakamura Y. , Scharlock M. , Ohtsuji M. , Kang M. , Kobayashi A. , Yokoyama S. , Yamamoto M.
      Mol. Cell21:689-700(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 76-84 IN COMPLEX WITH KEAP1
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