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Index > Protein center > NFKB1(Gene name) > Human
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  • NFKB1 (Gene name),
  • Nuclear factor NF-kappa-B p105 subunit (Protein name ),  NFKB1_HUMAN from NCBI database.
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  • Gene name:
    NFKB1;
    Protein name:
    Nuclear factor NF-kappa-B p105 subunit;
    Alternative:
    EBP-1;DNA-binding factor KBF1;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity). Directly interacts with MEN1.
    Function:
    NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.
    Subcellular Location:
    Nucleus Cytoplasm Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor.
    Protein Attributes:
    Sequence length:
    968
    Sequence:
    50:
    MAEDDPYLGR | PEQMFHLDPS | LTHTIFNPEV | FQPQMALPTD | GPYLQILEQP | 
    100:
    KQRGFRFRYV | CEGPSHGGLP | GASSEKNKKS | YPQVKICNYV | GPAKVIVQLV | 
    150:
    TNGKNIHLHA | HSLVGKHCED | GICTVTAGPK | DMVVGFANLG | ILHVTKKKVF | 
    200:
    ETLEARMTEA | CIRGYNPGLL | VHPDLAYLQA | EGGGDRQLGD | REKELIRQAA | 
    250:
    LQQTKEMDLS | VVRLMFTAFL | PDSTGSFTRR | LEPVVSDAIY | DSKAPNASNL | 
    300:
    KIVRMDRTAG | CVTGGEEIYL | LCDKVQKDDI | QIRFYEEEEN | GGVWEGFGDF | 
    350:
    SPTDVHRQFA | IVFKTPKYKD | INITKPASVF | VQLRRKSDLE | TSEPKPFLYY | 
    400:
    PEIKDKEEVQ | RKRQKLMPNF | SDSFGGGSGA | GAGGGGMFGS | GGGGGGTGST | 
    450:
    GPGYSFPHYG | FPTYGGITFH | PGTTKSNAGM | KHGTMDTESK | KDPEGCDKSD | 
    500:
    DKNTVNLFGK | VIETTEQDQE | PSEATVGNGE | VTLTYATGTK | EESAGVQDNL | 
    550:
    FLEKAMQLAK | RHANALFDYA | VTGDVKMLLA | VQRHLTAVQD | ENGDSVLHLA | 
    600:
    IIHLHSQLVR | DLLEVTSGLI | SDDIINMRND | LYQTPLHLAV | ITKQEDVVED | 
    650:
    LLRAGADLSL | LDRLGNSVLH | LAAKEGHDKV | LSILLKHKKA | ALLLDHPNGD | 
    700:
    GLNAIHLAMM | SNSLPCLLLL | VAAGADVNAQ | EQKSGRTALH | LAVEHDNISL | 
    750:
    AGCLLLEGDA | HVDSTTYDGT | TPLHIAAGRG | STRLAALLKA | AGADPLVENF | 
    800:
    EPLYDLDDSW | ENAGEDEGVV | PGTTPLDMAT | SWQVFDILNG | KPYEPEFTSD | 
    850:
    DLLAQGDMKQ | LAEDVKLQLY | KLLEIPDPDK | NWATLAQKLG | LGILNNAFRL | 
    900:
    SPAPSKTLMD | NYEVSGGTVR | ELVEALRQMG | YTEAIEVIQA | ASSPVKTTSQ | 
    950:
    AHSLPLSPAS | TRQQIDELRD | SDSVCDSGVE | TSFRKLSFTE | SLTSGASLLT | 
    968:
    LNKMPHDYGQ | EGPLEGKI
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    String:
    UniGene:
    KEGG:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    E1824h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    E1824r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    E1824d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    E1824c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    E1824m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    U1824m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    U1824c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    U1824d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    U1824r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    U1824h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Nuclear factor NF-kappa-B p105 subunit
    Polyclonal Antibody for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    P1824Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Nuclear factor NF-kappa-B p105 subunit
    Polyclonal Antibody for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    P1824Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    P1824Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Nuclear factor NF-kappa-B p105 subunit
    Monoclonal Antibody for Human Nuclear factor NF-kappa-B p105 subunit
    Monoclonal Antibody for Human Nuclear factor NF-kappa-B p105 subunit
    Monoclonal Antibody for Human Nuclear factor NF-kappa-B p105 subunit
    Monoclonal Antibody for Human Nuclear factor NF-kappa-B p105 subunit
    Protein for Human Nuclear factor NF-kappa-B p105 subunit
    Protein for Human Nuclear factor NF-kappa-B p105 subunit
    Protein for Human Nuclear factor NF-kappa-B p105 subunit
    Protein for Human Nuclear factor NF-kappa-B p105 subunit
    Protein for Human Nuclear factor NF-kappa-B p105 subunit

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product."
      Kieran M. , Blank V. , Logeat F. , Vandekerckhove J. , Lottspeich F. , le Bail O. , Urban M.B. , Kourilsky P. , Baeuerle P.A. , Israel A.
      Cell62:1007-1018(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PARTIAL PROTEIN SEQUENCE
    2. 2.
      "Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs."
      Bours V. , Villalobos J. , Burd P.R. , Kelly K. , Siebenlist U.
      Nature348:76-80(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha."
      Meyer R. , Hatada E.N. , Hohmann H.-P. , Haiker M. , Bartsch C. , Roethlisberger U. , Lahm H.-W. , Schlaeger E.J. , van Loon A.P.G.M. , Scheidereit C.
      Proc. Natl. Acad. Sci. U.S.A.88:966-970(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
    4. 4.
      "The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-kappa B and I kappa B-gamma: implications for NF-kappa B-mediated signal transduction."
      Heron E. , Deloukas P. , van Loon A.P.G.M.
      Genomics30:493-505(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Genome sequencing of the chromosome 4q region implicated in human hepatocellular carcinoma pathogenesis."
      Chang H.-M. , Tsai S.-F.
      Submitted (1999-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      tissue: Brain.
      tissue: Hippocampus.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Rectum tumor.
    8. 8.
      NIEHS SNPs program
      Submitted (2003-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-489; VAL-506; ILE-566; LYS-578; GLN-711 AND THR-901
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Muscle.
      tissue: Uterus.
    10. 10.
      "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene."
      Hansen S.K. , Nerlov C. , Zabel U. , Verde P. , Johnsen M. , Baeuerle P.A. , Blasi F.
      EMBO J.11:205-213(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NF-KAPPA-B P65-P50 COMPLEX
    11. 11.
      "The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B."
      Palombella V.J. , Rando O.J. , Goldberg A.L. , Maniatis T.
      Cell78:773-785(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
    12. 12.
      "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor."
      Beg A.A. , Baldwin A.S. Jr.
      Oncogene9:1487-1492(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NF-KAPPA-B P50-C-REL COMPLEX
    13. 13.
      "A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit."
      Lin L. , Ghosh S.
      Mol. Cell. Biol.16:2248-2254(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING OF P105;GENERATION OF P50 AND P105
    14. 14.
      "Inhibition of NF-kappaB DNA binding by nitric oxide."
      Matthews J.R. , Botting C.H. , Panico M. , Morris H.R. , Hay R.T.
      Nucleic Acids Res.24:2236-2242(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION AT CYS-61;MUTAGENESIS OF CYS-61;IDENTIFICATION BY MASS SPECTROMETRY
    15. 15.
      "A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription."
      Li Z. , Nabel G.J.
      Mol. Cell. Biol.17:6184-6190(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NFKBIE
    16. 16.
      "Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome."
      Lin L. , DeMartino G.N. , Greene W.C.
      Cell92:819-828(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COTRANSLATIONAL FOLDING/PROCESSING OF P105;GENERATION OF P50/P105
    17. 17.
      "NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes."
      Heissmeyer V. , Krappmann D. , Wulczyn F.G. , Scheidereit C.
      EMBO J.18:4766-4778(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH BCL3;MUTAGENESIS OF SER-921; SER-923 AND SER-932
    18. 18.
      "TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105."
      Belich M.P. , Salmeron A. , Johnston L.H. , Ley S.C.
      Nature397:363-368(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K8
    19. 19.
      "Cotranslational dimerization of the Rel homology domain of NF-kappaB1 generates p50-p105 heterodimers and is required for effective p50 production."
      Lin L. , DeMartino G.N. , Greene W.C.
      EMBO J.19:4712-4722(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COTRANSLATIONAL FOLDING/PROCESSING OF P105;GENERATION OF P50/P105;P50-P105 TRANSIENT HETERODIMER FORMATION
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA3
    21. 21.
      "Inhibition of NF-kappaB by S-nitrosylation."
      Marshall H.E. , Stamler J.S.
      Biochemistry40:1688-1693(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION
    22. 22.
      "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappa B."
      Ayroldi E. , Migliorati G. , Bruscoli S. , Marchetti C. , Zollo O. , Cannarile L. , D'Adamio F. , Riccardi C.
      Blood98:743-753(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DSIPI
    23. 23.
      "15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit."
      Cernuda-Morollon E. , Pineda-Molina E. , Canada F.J. , Perez-Sala D.
      J. Biol. Chem.276:35530-35536(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIPIDATION AT CYS-61;MUTAGENESIS OF CYS-61
    24. 24.
      "Direct phosphorylation of NF-kappa B1 p105 by the Ikappa B kinase complex on serine 927 is essential for signal-induced p105 proteolysis."
      Salmeron A. , Janzen J. , Soneji Y. , Bump N. , Kamens J. , Allen H. , Ley S.C.
      J. Biol. Chem.276:22215-22222(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-927
    25. 25.
      "The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation."
      Heppner C. , Bilimoria K.Y. , Agarwal S.K. , Kester M. , Whitty L.J. , Guru S.C. , Chandrasekharappa S.C. , Collins F.S. , Spiegel A.M. , Marx S.J. , Burns A.L.
      Oncogene20:4917-4925(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MEN1
    26. 26.
      "Casper/c-FLIP is physically and functionally associated with NF-kappaB1 p105."
      Li Z. , Zhang J. , Chen D. , Shu H.B.
      Biochem. Biophys. Res. Commun.309:980-985(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CFLAR
    27. 27.
      "Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins."
      Furia B. , Deng L. , Wu K. , Baylor S. , Kehn K. , Li H. , Donnelly R. , Coleman T. , Kashanchi F.
      J. Biol. Chem.277:4973-4980(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-431; LYS-440 AND LYS-441
    28. 28.
      "Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10."
      Berrebi D. , Bruscoli S. , Cohen N. , Foussat A. , Migliorati G. , Bouchet-Delbos L. , Maillot M.-C. , Portier A. , Couderc J. , Galanaud P. , Peuchmaur M. , Riccardi C. , Emilie D.
      Blood101:729-738(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DSIPI
    29. 29.
      "Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation."
      Deng W.G. , Zhu Y. , Wu K.K.
      J. Biol. Chem.278:4770-4777(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION
    30. 30.
      "Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability."
      Demarchi F. , Bertoli C. , Sandy P. , Schneider C.
      J. Biol. Chem.278:39583-39590(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GSK3B;PHOSPHORYLATION AT SER-903 AND SER-907;MUTAGENESIS OF SER-903 AND SER-907
    31. 31.
      "betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932."
      Lang V. , Janzen J. , Fischer G.Z. , Soneji Y. , Beinke S. , Salmeron A. , Allen H. , Hay R.T. , Ben-Neriah Y. , Ley S.C.
      Mol. Cell. Biol.23:402-413(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-927 AND SER-932
    32. 32.
      "Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB."
      Zhang J. , Xu L.-G. , Han K.-J. , Shu H.-B.
      J. Biol. Chem.279:17819-17825(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UNC5CL
    33. 33.
      "ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."
      Lang V. , Symons A. , Watton S.J. , Janzen J. , Soneji Y. , Beinke S. , Howell S. , Ley S.C.
      Mol. Cell. Biol.24:5235-5248(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K8 AND TNIP2
    34. 34.
      "Leishmania major amastigotes induce p50/c-Rel NF-kappa B transcription factor in human macrophages: involvement in cytokine synthesis."
      Guizani-Tabbane L. , Ben-Aissa K. , Belghith M. , Sassi A. , Dellagi K.
      Infect. Immun.72:2582-2589(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NF-KAPPA-B P50-C-REL COMPLEX
    35. 35.
      "Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105."
      Beinke S. , Robinson M.J. , Hugunin M. , Ley S.C.
      Mol. Cell. Biol.24:9658-9667(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAP3K8
    36. 36.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPAG9
    37. 37.
      "Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)."
      Cockman M.E. , Lancaster D.E. , Stolze I.P. , Hewitson K.S. , McDonough M.A. , Coleman M.L. , Coles C.H. , Yu X. , Hay R.T. , Ley S.C. , Pugh C.W. , Oldham N.J. , Masson N. , Schofield C.J. , Ratcliffe P.J.
      Proc. Natl. Acad. Sci. U.S.A.103:14767-14772(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIF1AN;HYDROXYLATION AT ASN-678;MUTAGENESIS OF ASN-678
    38. 38.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    39. 39.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-937;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    40. 40.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    41. 41.
      "Structure of the NF-kappa B p50 homodimer bound to DNA."
      Mueller C.W. , Rey F.A. , Sodeoka M. , Verdine G.L. , Harrison S.C.
      Nature373:311-317(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 1-365
    42. 42.
      "Structure of an IkappaBalpha/NF-kappaB complex."
      Jacobs M.D. , Harrison S.C.
      Cell95:749-758(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 248-354
    43. 43.
      "Solution structure of the death domain in human nuclear factor NF-kappa-B p105 subunit."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2006-12) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 804-893
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