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Index > Protein center > NOTCH4(Gene name) > Human
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  • NOTCH4 (Gene name),
  • Neurogenic locus notch homolog protein 4 (Protein name ),  NOTC4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    NOTCH4(INT3);
    Protein name:
    Neurogenic locus notch homolog protein 4(Notch 4;hNotch4);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.
    Function:
    Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.
    Subcellular Location:
    Notch 4 intracellular domain Nucleus Following proteolytical processing NICD is translocated to the nucleus.
    Protein Attributes:
    Sequence length:
    2003
    Sequence:
    50:
    MQPPSLLLLL | LLLLLLCVSV | VRPRGLLCGS | FPEPCANGGT | CLSLSLGQGT | 
    100:
    CQCAPGFLGE | TCQFPDPCQN | AQLCQNGGSC | QALLPAPLGL | PSSPSPLTPS | 
    150:
    FLCTCLPGFT | GERCQAKLED | PCPPSFCSKR | GRCHIQASGR | PQCSCMPGWT | 
    200:
    GEQCQLRDFC | SANPCVNGGV | CLATYPQIQC | HCPPGFEGHA | CERDVNECFQ | 
    250:
    DPGPCPKGTS | CHNTLGSFQC | LCPVGQEGPR | CELRAGPCPP | RGCSNGGTCQ | 
    300:
    LMPEKDSTFH | LCLCPPGFIG | PDCEVNPDNC | VSHQCQNGGT | CQDGLDTYTC | 
    350:
    LCPETWTGWD | CSEDVDECET | QGPPHCRNGG | TCQNSAGSFH | CVCVSGWGGT | 
    400:
    SCEENLDDCI | AATCAPGSTC | IDRVGSFSCL | CPPGRTGLLC | HLEDMCLSQP | 
    450:
    CHGDAQCSTN | PLTGSTLCLC | QPGYSGPTCH | QDLDECLMAQ | QGPSPCEHGG | 
    500:
    SCLNTPGSFN | CLCPPGYTGS | RCEADHNECL | SQPCHPGSTC | LDLLATFHCL | 
    550:
    CPPGLEGQLC | EVETNECASA | PCLNHADCHD | LLNGFQCICL | PGFSGTRCEE | 
    600:
    DIDECRSSPC | ANGGQCQDQP | GAFHCKCLPG | FEGPRCQTEV | DECLSDPCPV | 
    650:
    GASCLDLPGA | FFCLCPSGFT | GQLCEVPLCA | PNLCQPKQIC | KDQKDKANCL | 
    700:
    CPDGSPGCAP | PEDNCTCHHG | HCQRSSCVCD | VGWTGPECEA | ELGGCISAPC | 
    750:
    AHGGTCYPQP | SGYNCTCPTG | YTGPTCSEEM | TACHSGPCLN | GGSCNPSPGG | 
    800:
    YYCTCPPSHT | GPQCQTSTDY | CVSAPCFNGG | TCVNRPGTFS | CLCAMGFQGP | 
    850:
    RCEGKLRPSC | ADSPCRNRAT | CQDSPQGPRC | LCPTGYTGGS | CQTLMDLCAQ | 
    900:
    KPCPRNSHCL | QTGPSFHCLC | LQGWTGPLCN | LPLSSCQKAA | LSQGIDVSSL | 
    950:
    CHNGGLCVDS | GPSYFCHCPP | GFQGSLCQDH | VNPCESRPCQ | NGATCMAQPS | 
    1000:
    GYLCQCAPGY | DGQNCSKELD | ACQSQPCHNH | GTCTPKPGGF | HCACPPGFVG | 
    1050:
    LRCEGDVDEC | LDQPCHPTGT | AACHSLANAF | YCQCLPGHTG | QWCEVEIDPC | 
    1100:
    HSQPCFHGGT | CEATAGSPLG | FICHCPKGFE | GPTCSHRAPS | CGFHHCHHGG | 
    1150:
    LCLPSPKPGF | PPRCACLSGY | GGPDCLTPPA | PKGCGPPSPC | LYNGSCSETT | 
    1200:
    GLGGPGFRCS | CPHSSPGPRC | QKPGAKGCEG | RSGDGACDAG | CSGPGGNWDG | 
    1250:
    GDCSLGVPDP | WKGCPSHSRC | WLLFRDGQCH | PQCDSEECLF | DGYDCETPPA | 
    1300:
    CTPAYDQYCH | DHFHNGHCEK | GCNTAECGWD | GGDCRPEDGD | PEWGPSLALL | 
    1350:
    VVLSPPALDQ | QLFALARVLS | LTLRVGLWVR | KDRDGRDMVY | PYPGARAEEK | 
    1400:
    LGGTRDPTYQ | ERAAPQTQPL | GKETDSLSAG | FVVVMGVDLS | RCGPDHPASR | 
    1450:
    CPWDPGLLLR | FLAAMAAVGA | LEPLLPGPLL | AVHPHAGTAP | PANQLPWPVL | 
    1500:
    CSPVAGVILL | ALGALLVLQL | IRRRRREHGA | LWLPPGFTRR | PRTQSAPHRR | 
    1550:
    RPPLGEDSIG | LKALKPKAEV | DEDGVVMCSG | PEEGEEVGQA | EETGPPSTCQ | 
    1600:
    LWSLSGGCGA | LPQAAMLTPP | QESEMEAPDL | DTRGPDGVTP | LMSAVCCGEV | 
    1650:
    QSGTFQGAWL | GCPEPWEPLL | DGGACPQAHT | VGTGETPLHL | AARFSRPTAA | 
    1700:
    RRLLEAGANP | NQPDRAGRTP | LHAAVAADAR | EVCQLLLRSR | QTAVDARTED | 
    1750:
    GTTPLMLAAR | LAVEDLVEEL | IAAQADVGAR | DKWGKTALHW | AAAVNNARAA | 
    1800:
    RSLLQAGADK | DAQDNREQTP | LFLAAREGAV | EVAQLLLGLG | AARELRDQAG | 
    1850:
    LAPADVAHQR | NHWDLLTLLE | GAGPPEARHK | ATPGREAGPF | PRARTVSVSV | 
    1900:
    PPHGGGALPR | CRTLSAGAGP | RGGGACLQAR | TWSVDLAARG | GGAYSHCRSL | 
    1950:
    SGVGAGGGPT | PRGRRFSAGM | RGPRPNPAIM | RGRYGVAAGR | GGRVSTDDWP | 
    2000:
    CDWVALGACG | SASNIPIPPP | CLTPSPERGS | PQLDCGPPAL | QEMPINQGGE | 
    2003:
    GKK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    String:
    MIM:
    Pfam:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Notch 4
    Cat.:
    E2421h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Notch 4
    Cat.:
    E2421m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Notch 4
    Cat.:
    U2421h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Notch 4
    Cat.:
    U2421m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Notch 4
    Cat.:
    P2421Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Notch 4
    Cat.:
    P2421Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Notch 4
    Monoclonal Antibody for Human Notch 4
    Protein for Human Notch 4
    Protein for Human Notch 4

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3."
      Sugaya K. , Sasanuma S. , Nohata J. , Kimura T. , Fukagawa T. , Nakamura Y. , Ando A. , Inoko H. , Ikemura T. , Mita K.
      Gene189:235-244(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);POLYMORPHISM OF POLY-LEU REGION
      tissue: Placenta.
    2. 2.
      "Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene."
      Li L. , Huang G.M. , Banta A.B. , Deng Y. , Smith T. , Dong P. , Friedman C. , Chen L. , Trask B.J. , Spies T. , Rowen L. , Hood L.
      Genomics51:45-58(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3)
      tissue: Bone marrow.
      tissue: Heart.
    3. 3.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLN-117
    4. 4.
      "Human notch4 gene variant."
      Miyagawa T. , Tokunaga K. , Hojho H.
      Submitted (1999-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-503;VARIANTS GLN-117 AND GLN-317
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF LIGANDS
    6. 6.
      "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors."
      Wu L. , Aster J.C. , Blacklow S.C. , Lake R. , Artavanis-Tsakonas S. , Griffin J.D.
      Nat. Genet.26:484-489(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAML1
    7. 7.
      "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors."
      Wu L. , Sun T. , Kobayashi K. , Gao P. , Griffin J.D.
      Mol. Cell. Biol.22:7688-7700(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAML2 AND MAML3
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