Protein name:
Neurogenic locus notch homolog protein 4(Notch 4;hNotch4);
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.
Function:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.
Subcellular Location:
Notch 4 intracellular domain
Nucleus
Following proteolytical processing NICD is translocated to the nucleus.
Protein Attributes:
50:
MQPPSLLLLL | LLLLLLCVSV | VRPRGLLCGS | FPEPCANGGT | CLSLSLGQGT |
100:
CQCAPGFLGE | TCQFPDPCQN | AQLCQNGGSC | QALLPAPLGL | PSSPSPLTPS |
150:
FLCTCLPGFT | GERCQAKLED | PCPPSFCSKR | GRCHIQASGR | PQCSCMPGWT |
200:
GEQCQLRDFC | SANPCVNGGV | CLATYPQIQC | HCPPGFEGHA | CERDVNECFQ |
250:
DPGPCPKGTS | CHNTLGSFQC | LCPVGQEGPR | CELRAGPCPP | RGCSNGGTCQ |
300:
LMPEKDSTFH | LCLCPPGFIG | PDCEVNPDNC | VSHQCQNGGT | CQDGLDTYTC |
350:
LCPETWTGWD | CSEDVDECET | QGPPHCRNGG | TCQNSAGSFH | CVCVSGWGGT |
400:
SCEENLDDCI | AATCAPGSTC | IDRVGSFSCL | CPPGRTGLLC | HLEDMCLSQP |
450:
CHGDAQCSTN | PLTGSTLCLC | QPGYSGPTCH | QDLDECLMAQ | QGPSPCEHGG |
500:
SCLNTPGSFN | CLCPPGYTGS | RCEADHNECL | SQPCHPGSTC | LDLLATFHCL |
550:
CPPGLEGQLC | EVETNECASA | PCLNHADCHD | LLNGFQCICL | PGFSGTRCEE |
600:
DIDECRSSPC | ANGGQCQDQP | GAFHCKCLPG | FEGPRCQTEV | DECLSDPCPV |
650:
GASCLDLPGA | FFCLCPSGFT | GQLCEVPLCA | PNLCQPKQIC | KDQKDKANCL |
700:
CPDGSPGCAP | PEDNCTCHHG | HCQRSSCVCD | VGWTGPECEA | ELGGCISAPC |
750:
AHGGTCYPQP | SGYNCTCPTG | YTGPTCSEEM | TACHSGPCLN | GGSCNPSPGG |
800:
YYCTCPPSHT | GPQCQTSTDY | CVSAPCFNGG | TCVNRPGTFS | CLCAMGFQGP |
850:
RCEGKLRPSC | ADSPCRNRAT | CQDSPQGPRC | LCPTGYTGGS | CQTLMDLCAQ |
900:
KPCPRNSHCL | QTGPSFHCLC | LQGWTGPLCN | LPLSSCQKAA | LSQGIDVSSL |
950:
CHNGGLCVDS | GPSYFCHCPP | GFQGSLCQDH | VNPCESRPCQ | NGATCMAQPS |
1000:
GYLCQCAPGY | DGQNCSKELD | ACQSQPCHNH | GTCTPKPGGF | HCACPPGFVG |
1050:
LRCEGDVDEC | LDQPCHPTGT | AACHSLANAF | YCQCLPGHTG | QWCEVEIDPC |
1100:
HSQPCFHGGT | CEATAGSPLG | FICHCPKGFE | GPTCSHRAPS | CGFHHCHHGG |
1150:
LCLPSPKPGF | PPRCACLSGY | GGPDCLTPPA | PKGCGPPSPC | LYNGSCSETT |
1200:
GLGGPGFRCS | CPHSSPGPRC | QKPGAKGCEG | RSGDGACDAG | CSGPGGNWDG |
1250:
GDCSLGVPDP | WKGCPSHSRC | WLLFRDGQCH | PQCDSEECLF | DGYDCETPPA |
1300:
CTPAYDQYCH | DHFHNGHCEK | GCNTAECGWD | GGDCRPEDGD | PEWGPSLALL |
1350:
VVLSPPALDQ | QLFALARVLS | LTLRVGLWVR | KDRDGRDMVY | PYPGARAEEK |
1400:
LGGTRDPTYQ | ERAAPQTQPL | GKETDSLSAG | FVVVMGVDLS | RCGPDHPASR |
1450:
CPWDPGLLLR | FLAAMAAVGA | LEPLLPGPLL | AVHPHAGTAP | PANQLPWPVL |
1500:
CSPVAGVILL | ALGALLVLQL | IRRRRREHGA | LWLPPGFTRR | PRTQSAPHRR |
1550:
RPPLGEDSIG | LKALKPKAEV | DEDGVVMCSG | PEEGEEVGQA | EETGPPSTCQ |
1600:
LWSLSGGCGA | LPQAAMLTPP | QESEMEAPDL | DTRGPDGVTP | LMSAVCCGEV |
1650:
QSGTFQGAWL | GCPEPWEPLL | DGGACPQAHT | VGTGETPLHL | AARFSRPTAA |
1700:
RRLLEAGANP | NQPDRAGRTP | LHAAVAADAR | EVCQLLLRSR | QTAVDARTED |
1750:
GTTPLMLAAR | LAVEDLVEEL | IAAQADVGAR | DKWGKTALHW | AAAVNNARAA |
1800:
RSLLQAGADK | DAQDNREQTP | LFLAAREGAV | EVAQLLLGLG | AARELRDQAG |
1850:
LAPADVAHQR | NHWDLLTLLE | GAGPPEARHK | ATPGREAGPF | PRARTVSVSV |
1900:
PPHGGGALPR | CRTLSAGAGP | RGGGACLQAR | TWSVDLAARG | GGAYSHCRSL |
1950:
SGVGAGGGPT | PRGRRFSAGM | RGPRPNPAIM | RGRYGVAAGR | GGRVSTDDWP |
2000:
CDWVALGACG | SASNIPIPPP | CLTPSPERGS | PQLDCGPPAL | QEMPINQGGE |
Vaild Sequence:
Related Databases
Uniprot: