NR2C2 ELISA Kit for Human(Homo sapiens) | EIAab.comNR2C2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > NR2C2(Gene name) > Human

NR2C2 (Gene name),

Nuclear receptor subfamily 2 group C member 2 (Protein name ), NR2C2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NR2C2(TAK1;TR4);

Protein name:

Nuclear receptor subfamily 2 group C member 2;

Alternative:

Orphan nuclear receptor TR4;Orphan nuclear receptor TAK1;Testicular receptor 4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; can bind DNA as homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C1 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with PCAF; the interaction preferentially occurs on the nonphosphorylated form and induces NR2C2-mediated transactivation activity and does not require the ligand-binding domain. Interacts (MAPK-mediated phosphorylated form) with NRIP1; the interaction promotes repression of NR2C2-mediated activity (By similarity). Interacts with NR2C2AP; the interaction represses selective NR2C2-mediated transcriptional activity.

Function:

Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

596

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

596:

RLMSSNITEE | LFFTGLIGNV | SIDSIIPYIL | KMETAEYNGQ | ITGASL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000320447

UniGene:

Hs.555973

Pfam:

PF00104

MIM:

601426

SMR:

P49116

KEGG:

hsa:7182

String:

P49116

Uniprot:

P49116

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ELISA Kit for Human Nuclear receptor subfamily 2 group C member 2

Cat.:

E10644m

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MSDS:

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Packing:

96T

ELISA Kit for Human Nuclear receptor subfamily 2 group C member 2

Cat.:

E10644r

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MSDS:

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Packing:

96T

ELISA Kit for Human Nuclear receptor subfamily 2 group C member 2

Cat.:

E10644h

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MSDS:

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Packing:

96T

CLIA Kit for Human Nuclear receptor subfamily 2 group C member 2

Cat.:

U10644h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Nuclear receptor subfamily 2 group C member 2

Cat.:

U10644r

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Nuclear receptor subfamily 2 group C member 2

Cat.:

U10644m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Nuclear receptor subfamily 2 group C member 2

Cat.:

P10644Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Nuclear receptor subfamily 2 group C member 2

Monoclonal Antibody for Human Nuclear receptor subfamily 2 group C member 2

Protein for Human Nuclear receptor subfamily 2 group C member 2

Cat.:

R10644h

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Packing:

1mg

Purity:

>90%

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily."
Hirose T. , Fujimoto W. , Yamaai T. , Kim K.H. , Matsuura H. , Jetten A.M.
Mol. Endocrinol.8:1667-1680(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Testis.
2.

"Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily."
Chang C. , da Silva S.L. , Ideta R. , Lee Y. , Yeh S. , Burbach J.P.
Proc. Natl. Acad. Sci. U.S.A.91:6040-6044(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Prostate.
tissue: Testis.
3.

"DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system."
Kobayashi T. , Kodani Y. , Nozawa A. , Endo Y. , Sawasaki T.
FEBS Lett.582:2737-2744(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);DNA-BINDING SPECIFICITY
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The orphan receptor TAK1 acts as a repressor of RAR-, RXR- and T3R-mediated signaling pathways."
Hirose T. , Apfel R. , Pfahl M. , Jetten A.M.
Biochem. Biophys. Res. Commun.211:83-91(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;FUNCTION
8.

"Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4."
Yan Z.H. , Karam W.G. , Staudinger J.L. , Medvedev A. , Ghanayem B.I. , Jetten A.M.
J. Biol. Chem.273:10948-10957(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;INTERACTION WITH NRIP1;FUNCTION
9.

"Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor."
Lee Y.F. , Young W.J. , Lin W.J. , Shyr C.R. , Chang C.
J. Biol. Chem.274:16198-16205(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;FUNCTION
10.

"Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor."
Zhang Y. , Dufau M.L.
J. Biol. Chem.275:2763-2770(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
11.

"Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation."
Yang Y. , Wang X. , Dong T. , Kim E. , Lin W.-J. , Chang C.
J. Biol. Chem.278:7709-7717(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NR2C2AP
12.

"The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription."
Tanabe O. , Shen Y. , Liu Q. , Campbell A.D. , Kuroha T. , Yamamoto M. , Engel J.D.
Genes Dev.21:2832-2844(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HETERODIMERIZATION;FUNCTION
13.

"Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a."
Li G. , Lee Y.F. , Liu S. , Cai Y. , Xie S. , Liu N.C. , Bao B.Y. , Chen Z. , Chang C.
Endocrinology149:3490-3499(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
14.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19 AND SER-46;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
16.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-46; SER-68; SER-98 AND SER-219;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"NLRP10 enhances Shigella-induced pro-inflammatory responses."
Lautz K. , Damm A. , Menning M. , Wenger J. , Adam A.C. , Zigrino P. , Kremmer E. , Kufer T.A.
Cell. Microbiol.14:1568-1583(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLRP10

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