Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > NR2C2(Gene name) > Human
  • Add your favorite
  • NR2C2 (Gene name),
  • Nuclear receptor subfamily 2 group C member 2 (Protein name ),  NR2C2_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    NR2C2(TAK1;TR4);
    Protein name:
    Nuclear receptor subfamily 2 group C member 2;
    Alternative:
    Orphan nuclear receptor TR4;Orphan nuclear receptor TAK1;Testicular receptor 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; can bind DNA as homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C1 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with PCAF; the interaction preferentially occurs on the nonphosphorylated form and induces NR2C2-mediated transactivation activity and does not require the ligand-binding domain. Interacts (MAPK-mediated phosphorylated form) with NRIP1; the interaction promotes repression of NR2C2-mediated activity (By similarity). Interacts with NR2C2AP; the interaction represses selective NR2C2-mediated transcriptional activity.
    Function:
    Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    596
    Sequence:
    50:
    MTSPSPRIQI | ISTDSAVASP | QRIQIVTDQQ | TGQKIQIVTA | VDASGSPKQQ | 
    100:
    FILTSPDGAG | TGKVILASPE | TSSAKQLIFT | TSDNLVPGRI | QIVTDSASVE | 
    150:
    RLLGKTDVQR | PQVVEYCVVC | GDKASGRHYG | AVSCEGCKGF | FKRSVRKNLT | 
    200:
    YSCRSNQDCI | INKHHRNRCQ | FCRLKKCLEM | GMKMESVQSE | RKPFDVQREK | 
    250:
    PSNCAASTEK | IYIRKDLRSP | LIATPTFVAD | KDGARQTGLL | DPGMLVNIQQ | 
    300:
    PLIREDGTVL | LATDSKAETS | QGALGTLANV | VTSLANLSES | LNNGDTSEIQ | 
    350:
    PEDQSASEIT | RAFDTLAKAL | NTTDSSSSPS | LADGIDTSGG | GSIHVISRDQ | 
    400:
    STPIIEVEGP | LLSDTHVTFK | LTMPSPMPEY | LNVHYICESA | SRLLFLSMHW | 
    450:
    ARSIPAFQAL | GQDCNTSLVR | ACWNELFTLG | LAQCAQVMSL | STILAAIVNH | 
    500:
    LQNSIQEDKL | SGDRIKQVME | HIWKLQEFCN | SMAKLDIDGY | EYAYLKAIVL | 
    550:
    FSPDHPGLTS | TSQIEKFQEK | AQMELQDYVQ | KTYSEDTYRL | ARILVRLPAL | 
    596:
    RLMSSNITEE | LFFTGLIGNV | SIDSIIPYIL | KMETAEYNGQ | ITGASL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    MIM:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Nuclear receptor subfamily 2 group C member 2
    Cat.:
    E10644m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Nuclear receptor subfamily 2 group C member 2
    Cat.:
    E10644r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Nuclear receptor subfamily 2 group C member 2
    Cat.:
    E10644h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Nuclear receptor subfamily 2 group C member 2
    Cat.:
    U10644h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Nuclear receptor subfamily 2 group C member 2
    Cat.:
    U10644r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Nuclear receptor subfamily 2 group C member 2
    Cat.:
    U10644m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Nuclear receptor subfamily 2 group C member 2
    Cat.:
    P10644Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Nuclear receptor subfamily 2 group C member 2
    Polyclonal Antibody for Human Nuclear receptor subfamily 2 group C member 2
    Monoclonal Antibody for Human Nuclear receptor subfamily 2 group C member 2
    Monoclonal Antibody for Human Nuclear receptor subfamily 2 group C member 2
    Monoclonal Antibody for Human Nuclear receptor subfamily 2 group C member 2
    Protein for Human Nuclear receptor subfamily 2 group C member 2
    Protein for Human Nuclear receptor subfamily 2 group C member 2
    Protein for Human Nuclear receptor subfamily 2 group C member 2
    Cat.:
    R10644h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily."
      Hirose T. , Fujimoto W. , Yamaai T. , Kim K.H. , Matsuura H. , Jetten A.M.
      Mol. Endocrinol.8:1667-1680(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Testis.
    2. 2.
      "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily."
      Chang C. , da Silva S.L. , Ideta R. , Lee Y. , Yeh S. , Burbach J.P.
      Proc. Natl. Acad. Sci. U.S.A.91:6040-6044(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Prostate.
      tissue: Testis.
    3. 3.
      "DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system."
      Kobayashi T. , Kodani Y. , Nozawa A. , Endo Y. , Sawasaki T.
      FEBS Lett.582:2737-2744(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);DNA-BINDING SPECIFICITY
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The orphan receptor TAK1 acts as a repressor of RAR-, RXR- and T3R-mediated signaling pathways."
      Hirose T. , Apfel R. , Pfahl M. , Jetten A.M.
      Biochem. Biophys. Res. Commun.211:83-91(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;FUNCTION
    8. 8.
      "Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4."
      Yan Z.H. , Karam W.G. , Staudinger J.L. , Medvedev A. , Ghanayem B.I. , Jetten A.M.
      J. Biol. Chem.273:10948-10957(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;INTERACTION WITH NRIP1;FUNCTION
    9. 9.
      "Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor."
      Lee Y.F. , Young W.J. , Lin W.J. , Shyr C.R. , Chang C.
      J. Biol. Chem.274:16198-16205(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;FUNCTION
    10. 10.
      "Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor."
      Zhang Y. , Dufau M.L.
      J. Biol. Chem.275:2763-2770(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    11. 11.
      "Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation."
      Yang Y. , Wang X. , Dong T. , Kim E. , Lin W.-J. , Chang C.
      J. Biol. Chem.278:7709-7717(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NR2C2AP
    12. 12.
      "The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription."
      Tanabe O. , Shen Y. , Liu Q. , Campbell A.D. , Kuroha T. , Yamamoto M. , Engel J.D.
      Genes Dev.21:2832-2844(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HETERODIMERIZATION;FUNCTION
    13. 13.
      "Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a."
      Li G. , Lee Y.F. , Liu S. , Cai Y. , Xie S. , Liu N.C. , Bao B.Y. , Chen Z. , Chang C.
      Endocrinology149:3490-3499(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19 AND SER-46;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    16. 16.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-46; SER-68; SER-98 AND SER-219;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      "NLRP10 enhances Shigella-induced pro-inflammatory responses."
      Lautz K. , Damm A. , Menning M. , Wenger J. , Adam A.C. , Zigrino P. , Kremmer E. , Kufer T.A.
      Cell. Microbiol.14:1568-1583(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLRP10
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a KSR2 Gdf5
    Top Searches
    Ubiquitin-protein ligase Ubiquitin ELISA metalloproteinase Tumor necrosis Asprosin TRAP1A Alpha
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    Twitter