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Index > Protein center > OAT(Gene name) > Human
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  • OAT (Gene name),
  • Ornithine aminotransferase, mitochondrial (Protein name ),  OAT_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    OAT;
    Protein name:
    Ornithine aminotransferase, mitochondrial;
    Alternative:
    Ornithine--oxo-acid aminotransferase;Ornithine delta-aminotransferase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer.
    Function:
    N/A
    Subcellular Location:
    Mitochondrion matrix
    Protein Attributes:
    Sequence length:
    439
    Sequence:
    50:
    MFSKLAHLQR | FAVLSRGVHS | SVASATSVAT | KKTVQGPPTS | DDIFEREYKY | 
    100:
    GAHNYHPLPV | ALERGKGIYL | WDVEGRKYFD | FLSSYSAVNQ | GHCHPKIVNA | 
    150:
    LKSQVDKLTL | TSRAFYNNVL | GEYEEYITKL | FNYHKVLPMN | TGVEAGETAC | 
    200:
    KLARKWGYTV | KGIQKYKAKI | VFAAGNFWGR | TLSAISSSTD | PTSYDGFGPF | 
    250:
    MPGFDIIPYN | DLPALERALQ | DPNVAAFMVE | PIQGEAGVVV | PDPGYLMGVR | 
    300:
    ELCTRHQVLF | IADEIQTGLA | RTGRWLAVDY | ENVRPDIVLL | GKALSGGLYP | 
    350:
    VSAVLCDDDI | MLTIKPGEHG | STYGGNPLGC | RVAIAALEVL | EEENLAENAD | 
    400:
    KLGIILRNEL | MKLPSDVVTA | VRGKGLLNAI | VIKETKDWDA | WKVCLRLRDN | 
    439:
    GLLAKPTHGD | IIRFAPPLVI | KEDELRESIE | IINKTILSF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    UniGene:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ornithine aminotransferase, mitochondrial
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    E10566m
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    ELISA Kit for Human Ornithine aminotransferase, mitochondrial
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    E10566r
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    Packing:
    96T
    ELISA Kit for Human Ornithine aminotransferase, mitochondrial
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    ELISA Kit for Human Ornithine aminotransferase, mitochondrial
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    E10566h
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    CLIA Kit for Human Ornithine aminotransferase, mitochondrial
    Cat.:
    U10566h
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human Ornithine aminotransferase, mitochondrial
    Cat.:
    U10566m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ornithine aminotransferase, mitochondrial
    MSDS:
    Please sign in first.
    CLIA Kit for Human Ornithine aminotransferase, mitochondrial
    Cat.:
    U10566r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Ornithine aminotransferase, mitochondrial
    Polyclonal Antibody for Human Ornithine aminotransferase, mitochondrial
    Polyclonal Antibody for Human Ornithine aminotransferase, mitochondrial
    Polyclonal Antibody for Human Ornithine aminotransferase, mitochondrial
    Cat.:
    P10566Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ornithine aminotransferase, mitochondrial
    Monoclonal Antibody for Human Ornithine aminotransferase, mitochondrial
    Monoclonal Antibody for Human Ornithine aminotransferase, mitochondrial
    Monoclonal Antibody for Human Ornithine aminotransferase, mitochondrial
    Protein for Human Ornithine aminotransferase, mitochondrial
    Protein for Human Ornithine aminotransferase, mitochondrial
    Protein for Human Ornithine aminotransferase, mitochondrial
    Protein for Human Ornithine aminotransferase, mitochondrial

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Investigation of gyrate atrophy using a cDNA clone for human ornithine aminotransferase."
      Ramesh V. , Shaffer M.M. , Allaire J.M. , Shih V.E. , Gusella J.F.
      DNA5:493-501(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    3. 3.
      "Molecular cloning and nucleotide sequence analysis of mRNA for human kidney ornithine aminotransferase. An examination of ornithine aminotransferase isozymes between liver and kidney."
      Kobayashi T. , Nishii M. , Takagi Y. , Titani T. , Matsuzawa T.
      FEBS Lett.255:300-304(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 36-40;PROTEOLYTIC PROCESSING
      tissue: Kidney.
    4. 4.
      "Human ornithine-delta-aminotransferase. cDNA cloning and analysis of the structural gene."
      Mitchell G.A. , Looney J.E. , Brody L.C. , Steel G. , Suchanek M. , Engelhardt J.F. , Willard H.F. , Valle D.
      J. Biol. Chem.263:14288-14295(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
    5. 5.
      "Analysis of the human ornithine aminotransferase gene family."
      Zintz C.B. , Inana G.
      Exp. Eye Res.50:759-770(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
      tissue: Brain cortex.
      tissue: Subthalamic nucleus.
    7. 7.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain cortex.
    9. 9.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
      tissue: Uterus.
    12. 12.
      "Molecular pathology of gyrate atrophy of the choroid and retina due to ornithine aminotransferase deficiency."
      Ramesh V. , Gusella J.F. , Shih V.E.
      Mol. Biol. Med.8:81-93(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 50-58 AND 328-336 (ISOFORM 1)
    13. 13.
      "The primary structure of ornithine aminotransferase. Identification of active-site sequence and site of post-translational proteolysis."
      Simmaco M. , John R.A. , Barra D. , Bossa F.
      FEBS Lett.199:39-42(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;PYRIDOXAL PHOSPHATE AT LYS-292;PROTEOLYTIC PROCESSING
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition."
      Shah S.A. , Shen B.W. , Brunger A.T.
      Structure5:1067-1075(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS)
    16. 16.
      "Crystal structure of human recombinant ornithine aminotransferase."
      Shen B.W. , Hennig M. , Hohenester E. , Jansonius J.N. , Schirmer T.
      J. Mol. Biol.277:81-102(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
    17. 17.
      "Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine."
      Storici P. , Capitani G. , Mueller R. , Schirmer T. , Jansonius J.N.
      J. Mol. Biol.285:297-309(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS)
    18. 18.
      "Molecular basis of ornithine aminotransferase deficiency in B-6-responsive and -nonresponsive forms of gyrate atrophy."
      Ramesh V. , McClatchey A.I. , Ramesh N. , Benoit L.A. , Berson E.L. , Shih V.E. , Gusella J.F.
      Proc. Natl. Acad. Sci. U.S.A.85:3777-3780(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HOGA LYS-54 AND MET-332
    19. 19.
      "Point mutation affecting processing of the ornithine aminotransferase precursor protein in gyrate atrophy."
      Inana G. , Chambers C. , Hotta Y. , Inouye L. , Filpula D. , Pulford S. , Shiono T.
      J. Biol. Chem.264:17432-17436(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HOGA TYR-319
    20. 20.
      "Strand-separating conformational polymorphism analysis: efficacy of detection of point mutations in the human ornithine delta-aminotransferase gene."
      Michaud J. , Brody L.C. , Steel G. , Fontaine G. , Martin L.S. , Valle D. , Mitchell G.
      Genomics13:389-394(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HOGA THR-180; LEU-241; PRO-250; ASP-353 AND ARG-394
    21. 21.
      "Ornithine delta-aminotransferase mutations in gyrate atrophy. Allelic heterogeneity and functional consequences."
      Brody L.C. , Mitchell G.A. , Obie C. , Michaud J. , Steel G. , Fontaine G. , Robert M.-F. , Sipila I. , Kaiser-Kupfer M. , Valle D.
      J. Biol. Chem.267:3302-3307(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HOGA HIS-55; LYS-89; PHE-93; LEU-154; THR-180; ALA-184 DEL; LEU-241; CYS-245; PRO-250; ILE-267; LYS-271; ASP-353; ALA-375; ARG-394; PRO-402 AND LEU-417;VARIANT PHE-437
    22. 22.
      "Pyridoxine-responsive gyrate atrophy of the choroid and retina: clinical and biochemical correlates of the mutation A226V."
      Michaud J. , Thompson G.N. , Brody L.C. , Steel G. , Obie C. , Fontaine G. , Schappert K. , Keith C.G. , Valle D. , Mitchell G.A.
      Am. J. Hum. Genet.56:616-622(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HOGA VAL-226
    23. 23.
      "A single amino acid substitution within the mature sequence of ornithine aminotransferase obstructs mitochondrial entry of the precursor."
      Kobayashi T. , Ogawa H. , Kasahara M. , Shiozawa Z. , Matsuzawa T.
      Am. J. Hum. Genet.57:284-291(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HOGA GLU-90
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